Occlusal Disharmony Affects Plasma Corticosterone and Hypothalamic Noradrenaline Release in Rats

Abstract

Few neuro-endocrinological studies have examined the relationship between occlusal disharmony and stress. To determine the effect of occlusal disharmony on the central nervous system, we measured plasma corticosterone and extracellular noradrenaline in the vicinity of the hypothalamic paraventricular nucleus in rats both with and without incisal caps. After the caps were set, plasma corticosterone and extracellular noradrenaline levels gradually increased, reaching a peak at 8.5 and 6.5 hours, respectively, after which they decreased. Furthermore, plasma corticosterone and extracellular noradrenaline levels increased in a circadian fashion around the onset of the dark phase in rats without caps, but not in rats with caps. These results suggest that occlusal disharmony causes chronic stress in the rat.

Keywords

occlusal disharmony plasma corticosterone noradrenaline hypothalamus

Get full access to this article

View all access options for this article.

References

Areso MP , Giralt MT , Sainz B. , Prieto M. , Garcia-Vallejo P. , Gómez FM (1999). Occlusal disharmonies modulate central catecholaminergic activity in the rat. J Dent Res 78:1204-1213.

Bernard JF , Huang GF , Besson JM (1992). Nucleus centralis of the amygdala and the globus pallidus ventralis: electrophysiological evidence for an involvement in pain processes. J Neurophysiol 68:551-569.

Budtz-Jørgensen E. (1981). Occlusal dysfunction and stress. J Oral Rehabil 8:1-9.

Burstein R. , Dado RJ , Cliffer KD , Giesler GJ Jr (1991). Physiological characterization of spinohypothalamic tract neurons in the lumbar enlargement of rats. J Neurophysiol 66:261-284.

Glavin GB (1985). Stress and brain noradrenaline: a review. Neurosci Biobehav Rev 9:233-243.

Honma K. , Honma S. , Hiroshige T. (1984). Feeding-associated corticosterone peak in rats under various feeding cycles. Am J Physiol 246:R721-R726.

Irwin J. , Ahluwalia P. , Anisman H. (1986). Sensitization of norepinephrine activity following acute and chronic footshock. Brain Res 6379:98-103.

McQuade R. (2000). A microdialysis study of the noradrenergic response in rat frontal cortex and hypothalamus to a conditioned cue for aversive, naturalistic environmental stimuli. Psychopharmacology 148:201-208.

Menetrey D, Basbaum AI (1987). Spinal and trigeminal projections to

10.

Mitome M, Honma S, Yoshihara T, Honma K (1994). Prefeeding increase in paraventricular NE release is regulated by a feeding-associated rhythm in rats. Am J Physiol 266:E606-E611.

11.

Pacak K. , Armando I. , Fukuhara K. , Kvetnansky R. , Palkovits M. , Kopin IJ , et al. (1992). Noradrenergic activation in the paraventricular nucleus during acute and chronic immobilization stress in rats: an in vivo microdialysis study. Brain Res 589:91-96.

12.

Shibasaki T, Tsumori C, Hotta M, Imaki T, Yamada K, Demura H (1995). The response pattern of noradrenaline release to repeated stress in the hypothalamic paraventricular nucleus differs according to the form of stress in rats. Brain Res 670:169-172. Stanley BG, Schwartz DH, Hernandez L, Hoebel BG, Leibowitz SF (1989). Patterns of extracellular norepinephrine in the paraventricular hypothalamus: relationship to circadian rhythm and deprivation-induced eating behavior. Life Sci 45:275-282. Trub M, Mei N (1991). Effects of periodontal stimulation on VHM neurons in anesthetized rats. Brain Res Bull 27:29-34.

13.

Wiberg M. , Westman J. , Blomqvist A. (1987). Somatosensory projection to mesencephalon: an anatomical study in the monkey. J Comp Neurol 264:92-117.

14.

Yamashiro T, Satoh K, Nakagawa K, Moriyama H, Yagi T, Takada K (1998). Expression of Fos in the rat forebrain following experimental tooth movement. J Dent Res 77:1920-1925. Yezierski RP, Gerhart KD, Schrock BJ, Willis WD (1983). A further examination of effects of cortical stimulation on primate spinothalamic tract cells. J Neurophysiol 49:424-441.

15.

Yokota T. , Koyama N. (1983). Identification of neurons relaying trigeminal nociceptive input onto subnucleus reticularis ventralis in the cat. Neurosci Lett 36:273-278.

16.

Yoshihara T. , Honma S. , Honma K. (1996). Prefeeding release of paraventricular neuropeptide Y is mediated by ascending noradrenergic neurons in rats. Am J Physiol 270:E596-E600.