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Abstract

In this study, composite magnetic microspheres of tamarind gum and chitosan were prepared in a well-shaped spherical form with a size range of 230—46 0 μm by the suspension cross-linking technique for use in the application of magnetic carrier technology. The magnetic material used in the preparation of the microspheres was prepared by precipitation from FeCl₃ and FeSO₄ solutions in basic medium. The morphological, magnetic properties and the functional groups of the microspheres were characterized by different techniques (i.e., Scanning Electron Microscope (SEM), magnetometry, and FT-IR). The results demonstrated that the stirring rate of the suspension and the Fe₃O₄/chitosan ratio are the most effective parameters for the size/size distribution and the magnetic quality of the microspheres, while the amount of tamarind gum has no significant effect on these properties. The best magnetic quality of the microspheres is around 4.11 emu/g microspheres at 8 KG magnetic field intensity. The thermal stability was measured by using DSC methods.

Keywords

composite magnetic microspheres tamarind gum chitosan properties functional groups stability.

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References

Lei, H. , Wang, W. , Chen, L.L. , Li, X.C. , Yi, B. and Deng, L. (2004). The Preparation and Catalytically Active Characterization of Papain Immobilized on Magnetic Composite Microspheres, Enzyme Microb. Technol., 35(1): 15—21.

Guo, Z. , Bai, S. and Sun, Y. ( 2003). Preparation and Characterization of Immobilized Lipase on Magnetic Hydrophobic Microspheres, Enzyme Microb. Technol. , 32(7): 776—782.

Wang, J. , Bhattachargya, D. and Bachas, L.G. (2001). Orientation Specific Immobilization of Organophorus Hydrolase on Magnetic Particles through Gene Fusion, Biomacromolecules , 2(3): 700—705.

Thanoo, B.C. , Sunny, M.C. and Jayakreshan , A. (1992). Cross-linked Chitosan Microspheres: Preparation and Evaluation as a Matrix for the Controlled Release of Pharmaceuticals, J. Pharm. Pharmacol ., 44: 283—286.

Pavanetto, F. , Perugini, P. , Conti , B. , Modena, T. and Genta, I. (1996). Evaluation of Process Parameters Involved in Chitosan Microsphere Preparation by the O/W/O Multiple Emulsion Method J. Microencapsulation , 13: 679—688.

Chandy, T. and Sharma, C.P. (1993). Chitosan Matrix for Oral Sustained Delivery of Ampicillin, Biomaterials, 14(12): 939—944.

Takahashi, T. , Takayama, K. , Machida , Y. and Nagai, T. (1990). Characteristics of Polyion Complexes of Chitosan with Sodium Alginate and Sodium Polyacrylate, Int. J. Pharm., 61(1—2): 35—41.

Li, Y.P. , Machida, Y. , Sannan T. and Nagai, T. (1991). Preparation of Chitosan Microspheres Containing Fluorouracil using the `Dry-in-oil' Method and its Release Characteristics, STP Pharma Sci., 1: 363—368.

Genta, I. , Pavanetto, F. , Conti, B. , Giunchedi, P. and Conte, U. (1994). Spray-drying for the Preparation of Chitosan Microspheres , Proc. Int. Symp, Control Rel. Bioact. Mater., 21: 616—617.

10.

Berthold, A. , Cremer, K. and Kreuter, J. (1996). Preparation and Characterization of Chitosan Microspheres as Drug Carrier for Prednisolone Sodium Phosphate as Model for Anti-inflammatory Drugs, J. Control. Release , 39(1): 17—25.

11.

Madhan Kumar, A.B. and Panduranga Rao, K. (1998). Preparation and Characterization of pH-Sensitive Proteinoid Microspheres for the Oral Delivery of Methotrexate, Biomaterials, 19(7—9): 725—732.

12.

Denkas, E.B. , Kilicay, E. , Birlikseven , C. and Ozturk, E. (2002). Magnetic Chitosan Microspheres: Preparation and Characterization, Reac. Funct . Polym., 50(3): 225—232.

13.

Shantha, K.L. and Harding, D.R.K. (2002). Synthesis and Characterization of Chemically Modified Chitosan Microspheres, Carbohydr. Polym. , 48(3): 247—253.

14.

Giunchedi, P. , Genta, I. , Conti , B. , Muzzarelli, R.A.A. and Conte, U. (1998). Preparation and Characterization of Ampicillin Loaded Methylpyrrolidinone Chitosan and Chitosan Microspheres , Biomaterials, 19(1—3): 157—161.

15.

He, P. , Davis, S.S. and Illum, L. (1999). Chitosan Microspheres Prepared by Spray Drying , Int. J. Pharm., 187(1): 53—65.

16.

Tanyolac, D. and Ozdural, A.R. (2000). Preparation of Low-cost Magnetic Nitrocellulose Microbeads, React. Funct. Polym., 45(3): 235—242.

17.

Tanyolac, D. and Ozdural, A.R. (2000). A New Low Cost Magnetic Material: Magnetic Polyvinylbutyral Microbeads, React. Funct. Polym., 43(3): 279—286.

Preparation and Characterization of Composite Magnetic Microspheres

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