Low-Dose Theophylline Therapy-Or Sometimes Less is More

Emad A , Mostafavi H , Khajedehl P. Effectiveness of adding alternate-day Theophylline to the treatment regimen of patients with moderate-to-severe asthma. Respir Care 1996;41(6):520–523.

Kidney J , Dominguez M , Taylor PM , Chung KF , Barnes PJ . Immuno-modulation by theophylline in asthma. Demonstration by withdrawal of therapy. Am J Respir Crit Care Med. 1995;151(6):1907–1914.

Ward AJM , McKenniff M , Evans JM , Page CP , Costello JF . Theo-phylline an immunomodulatory role in asthma? Am Rev Respir Dis 1993;147(3):518–523.

Persson CG . Overview of effects of theophylline. J Allergy Clin Immunol 1986;78(4, Part 2):780–787.

Barnes PJ , Pauwels RA . Theophylline in the management of asthma: time for reappraisal. Eur Respir J 1994;7(3):579–591.

Sullivan P , Bekir S , Jaffar Z , Page C , Jeffery P , Costello J. Anti-inflammatory effects of low-dose oral theophylline in atopic asthma. Lancet 1994;343(8904):1006–1008. See the published erratum in Lancet 1994; 343(8911):1512.

Calhoun WJ , Stevens CA , Lambert SB . Modulation of superoxide production of alveolar macrophages and peripheral blood mononuclear cells by beta-agonists and theophylline. J Lab Clin Med 1991;117(6):514–522.

Mascali JJ , Crietusa P , Negri J , Borish L. Anti-inflammatory effects of theophylline: modulation of cytokine production. Ann Allerg Asthma Immunol. In press.

Holgate ST , Portridge MR . Compliance in asthma. Eur Respir Rev, 5, Review No. 26, April, 1995.

Rubinfeld AR , Pain MCF . Perception of asthma. Lancet 1976;1(7965):882–884.