ManthousCA. Liberation from mechanical ventilation, Parts I & II. Respir Care Clin North Am2000;6(2 & 3).
2.
TobinMJ, AlexCG. Discontinuation of mechanical ventilation. In: TobinMJ, editor. Principles and practice of mechanical ventilation. New York: McGraw-Hill1994;1177–1206.
3.
EstebanA, AliaI, IbanezJ, BenitoS, TobinMJH. Modes of mechanical ventilation and weaning: a national survey of Spanish hospitals. The Spanish Lung Failure Collaborative Group. Chest1994;106:1188–1193.
4.
CookD, MeadeM, GuyattG, GriffithL, BookerL.Evidence report on criteria for weaning from mechanical ventilation. AHCPR: Nov, 1999.
5.
RajuP, ManthousCA. The pathogenesis of respiratory failure. Respir Clin N Am2000;6(2):195–212.
6.
FishmanAP, TurinoGM, BergofskyEH. The syndrome of alveolar hypoventilation. Am J Med1957;23:333–339.
7.
DevereauxMW, KeaneJR, DavisRL. Automatic respiratory failure associated with infarction of the medulla. Arch Neurol1973;29:46–52.
8.
HughesJMB. Central respiratory failure reversed by treatment. Brain1967;90:675–680.
9.
VallverduI, ManceboJ.Approach to patients who fail initial weaning trials. Respir Care Clin N Am2000;6(3):365–384.
10.
LopataM, OnalE.Mass loading, sleep apnea, and the pathogenesis of obesity hypoventilation. Am Rev Respir Dis1982;126:640–645.
11.
OnalE, LopataM.Periodic breathing and pathogenesis of occlusive sleep apneas. Am Rev Respir Dis1982;128:676–680.
12.
DaumJJ, CanterHG, KatzS.Central nervous system sarcoidosis with alveolar hypoventilation. Am J Med1965;38:893–898.
13.
Barrientos-VegaR, Mar Sanchez-SoriaM, Morales-GarciaC, et al. Prolonged sedation of critically ill patients with midazolam or propofol: impact on weaning and costs. Crit Care Med1997;25:33–40.
14.
WheelerAP. Sedation, analgesia, and paralysis in the intensive care unit. Chest1993;104(2):566–577.
15.
DiehlJL, LofasoF, DeleuzeP, et al. Clinical relevant diaphragmatic dysfunction after cardiac operations. J Thoracic Cardiovasc Surg1994;107:487–498.
16.
Hansen-FlaschenJH, CowenJ, RapsEC, et al. Neuromuscular blockade in the intensive care unit: more than we bargained for. Am Rev Respir Dis1993;147:234–236.
17.
SegredoV, CaldwellJE, MatthayMA, et al. Persistent paralysis in critically ill patients after long administration of vecuronium. New Eng J Med1992;327:524–528.
18.
BellemareF, GrassinoA.Effect of pressure and timing of contraction on human diaphragm fatigue. J Appl Physiol1982;53:1190–1195.
19.
JubranA, TobinMJ. Passive mechanics of lung and chest wall in patients who failed or succeeded in trials of weaning. Am J Respir Crit Care Med1997;155:916–921.
20.
RoussosC, MacklemPT. The respiratory muscles. N Engl J Med1982;307:786–797.
NHLBI Workshop summary. Respiratory muscle fatigue: report of the respiratory muscle fatigue workshop group. Am Rev Respir Dis1990;142:474–480.
23.
TobinMJ, LaghiF.Monitoring respiratory muscle function. In: TobinMJ, editor. Principles and practice of intensive care monitoring. New York: McGraw-Hill1998;497–544.
24.
Le BourdellesG, ViiresN, BoezkowskiJ, et al. Effects of mechanical ventilation on diaphragmatic contractile properties in rats. Am J Respir Crit Care Med1994;149:1539–1544.
ReidWD, HuangJ, BrysonS, WalkerDC, BelcastroAN. Diaphragm injury and myofibrillar structure induced by resistive loading. J Appl Physiol1994;76:176–184.
28.
RochesterDF. Does respiratory muscle rest relieve fatigue or incipient fatigue?Am Rev Respir Dis1988;138:516–517.
29.
SwartzMA, MarinoPL. Diaphragmatic strength during weaning from mechanical ventilation. Chest1985;88:736–739.
30.
DecramerJ, LacquetLM, FagardR, et al. Corticosteroids contribute to muscle weakness in chronic airflow obstruction. Am J Respir Crit Care Med1994;150:11–16.
31.
GallagherCG. Respiratory steroid myopathy. Am J Respir Crit Care Med1994;150:4–6.
32.
LeeC.Intensive care unit neuromuscular syndrome?Anesthesiology1995;83:237–240.
33.
RossiA, GottfriedSB, ZocchiL, HiggsBD, LennoxS, CalverleyPM, et al. Measurement of static compliance of the total respiratory system in patients with acute respiratory failure during mechanical ventilation: the effect of intrinsic positive end-expiratory pressure. Am Rev Respir Dis1985;131(5):672–677.
34.
HilbermanM, KammB, LamyM, et al. An analysis of potential physiological predictors of respiratory adequacy following cardiac surgery. J Thorac Cardiovasc Surg1976;71:711–720.
35.
JabourER, RabilDM, TruwitJD, RochesterDF. Evaluation of a new weaning index based on ventilatory endurance and the efficiency of gas exchange. Am Rev Respir Dis1991;144:531–537.
36.
SassoonCS, MahutteCK. Airway occlusion pressure and breathing pattern as predictors of weaning outcome. Am Rev Respir Dis1993;148:860–866.
37.
KlineJL, ZimnickiGL, AntonenkoDR, BanderJJ. The use of calculated relative inspiratory effort as a predictor of outcome in mechanical ventilation weaning trials. Respir Care1987;32:870–876.
38.
el-KhatibMF, BaumeisterB, SmithPG, ChatburnRL, BlumerJL. Inspiratory pressure/maximal inspiratory pressure (Pimax): does it predict successful extubation in critically ill infants and children?Int Care Med1996;22:264–268.
39.
KhanN, BrownA, VenkataramanST. Predictors of extubation success and failure in mechanically ventilated infants and children. Crit Care Med1996;24:1568–1579.
40.
LeitchEA, MoranJL, GrealyB.Weaning and extubation in the intensive care unit: clinical or index-driven approach?Int Care Med1996;22:752–759.
41.
MergoniM, CostaA, PrimaveraS, SalvadoriA, SaccaniA, ZuccoliP.[Assessment of various new predictive parameters of the outcome of mechanical ventilation weaning]. Article in Italian. Minerva Anestesiol1996;62:153–164.
42.
GologorskiiVA, GelfandBR, StamovVI, LapshinaII, NistratovSL. [Cessation of prolonged artificial ventilation of the lungs and transition to spontaneous respiration of surgical patients]. Article in Russian. Anesteziol Reanimatol1997;1:4–10.
43.
KriegerBP, IsberJ, BreitenbucherA, ThroopG, ErshowskyP.Serial measurements of the rapid-shallow-breathing index as a predictor of weaning outcome in elderly medical patients. Chest1997;112:1029–1034.
44.
KriegerBP, ErshowskyPF, BeckerDA, GazerogluHB. Evaluation of conventional criteria for predicting successful weaning from mechanical ventilatory support in elderly patients. Crit Care Med1989;17:858–861.
45.
AshutoshK, LeeH, MohanCK, RankaS, MehrotraK, AlexanderC.Prediction criteria for successful weaning from respiratory support: statistical and connectionist analyses. Crit Care Med1992;20:1295–1301. [published erratum appears in Crit Care Med 1994 Jan;22(1):183.]
46.
SahnSA, LakshminarayanS.Bedside criteria for discontinuation of mechanical ventilation. Chest1973;63:1002–1005.
47.
GandiaF, BlancoJ.Evaluation of indexes predicting the outcome of ventilator weaning and value of adding supplemental inspiratory load. Int Care Med1992;18:327–333.
48.
FariasJA, AliaI, EstebanA, GolubickiAN, OlazarriFA. Weaning from mechanical ventilation in pediatric intensive care patients. Int Care Med1998;24:1070–1075.
49.
PetersRM, BrimmJE, UtleyJR. Predicting the need for prolonged ventilatory support in adult cardiac patients. J Thoracic Cardiovasc Surg1979;77:175–182.
50.
CohenCA, ZagelbaumG, GrossD, RoussosC, MacklemPT. Clinical manifestations of inspiratory muscle fatigue. Am J Med1982;73:308–316.
51.
EsauSA, BellemareF, GrassinoA, PermuttS, RoussosC, PardyRL. Changes in relaxation rate with diaphragmatic fatigue in humans. J Appl Physiol1983;54:1353–1360.
52.
JubranA, TobinMJ. Pathophysiological basis of acute respiratory distress in patients who fail a trial of weaning from mechanical ventilation. Am J Respir Crit Care Med1997;155:906–915.
53.
Mier-JedrzejowiczA, BrophyC, MoxhamJ, GreenM.Assessment of diaphragm weakness. Am Rev Respir Dis1988;137:877–883.
54.
TobinMJ. 1999Donald F Egan Scientific Lecture: Weaning from mechanical ventilation: what have we learned? Respir Care 2000;45:417–431.
55.
De TroyerA, EstenneM.Coordination between rib cage muscles and diaphragm during quiet breathing in humans. J Appl Physiol1984;57(6):899–906.
56.
GallagherCG, Im HofV, YounesM.Effect of inspiratory muscle fatigue on breathing pattern. J Appl Physiol1985;59:1152–1158.
57.
GilbertR, AuchinclossJH, PeppiD, AshutoshK.The first few hours off a respirator. Chest1974;65:152–157.
58.
SharpJT, GoldbergNB, DruzWS, FishmanHC, DanonJ.Thoracoabdominal motion in chronic obstructive pulmonary disease. Am Rev Respir Dis1977;115:47–56.
TobinMJ, GuentherSM, PerezW, et al. Konno-Mead analysis of rib cage-abdominal motion during successful and unsuccessful trials of weaning from mechanical ventilation. Am Rev Respir Dis1987;135:1320–1328.
61.
AubierM, MurcianoD, LecocguicY, ViiresN, ParienteR.Bilateral phrenic stimulation: a simple technique to assess diaphragmatic fatigue in humans. J Appl Physiol1985;58:58–64.
62.
DunnWF, NelsonSB, HubmayrRD. The control of breathing during weaning from mechanical ventilation. Chest1991;100:754–761.
63.
FieldS, KellySM, MacklemPT. The oxygen cost of breathing in patients with cardiorespiratory disease. Am Rev Respir Dis1982;126:9–13.
64.
HubmayrRD, LoosbrockLM, GillespieDJ, RodarteJR. Oxygen uptake during weaning from mechanical ventilation. Chest1988;94:1148–1155.
65.
MurcianoD, BoczkowskiJ, LecocguicY, Milic-EmiliJ, ParienteR, AubierM.Tracheal occlusion pressure: a simple index to monitor respiratory muscle fatigue during acute respiratory failure in patients with chronic obstructive pulmonary disease. Ann Intern Med1988;108:800–805.
66.
StroetzRW, HubmayrRD. Tidal volume maintenance during weaning with pressure support. Am J Respir Crit Care Med1995;152:1034–1040.
67.
GayPC, RodarteJR, HubmayrRD. The effects of positive expiratory pressure on isovolume flow and dynamic hyperinflation in patients receiving mechanical ventilation. Am Rev Respir Dis1989;139:621–626.
68.
ParthasarathyS, JubranA, TobinMJ. Cycling of inspiratory and expiratory muscle groups with the ventilator in airflow limitation. Am J Respir Crit Care Med1998;158:1471–1478.
69.
PepePE, MariniJJ. Occult positive end-expiratory pressure in mechanically ventilated patients with airflow obstruction: the auto-PEEP effect. Am Rev Respir Dis1982;126:166–170.
70.
ReinosoMA, GraceyDR, HubmayrRD. Interrupter mechanics of patients admitted to a chronic ventilator dependency unit. Am Rev Respir Dis1993;148:127–131.
71.
SassoonCSH, TeTT, MahutteK, LightRW. Airway occlusion pressure: an important indicator for successful weaning in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis1987;135:107–113.
72.
GandeviaSC. Neural control in human muscle fatigue: changes in muscle afferents, motoneurons and motor cortical drive. Acta Physiologica Scandinavica1998;162(2):275–283.
73.
YangKL, TobinMJ. A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation. N Engl J Med1991;324:1445–1450.
74.
PingletonSK, HarmonGS. Nutritional management in acute respiratory failure. JAMA1987;257:3094–3099.
75.
LewisMI, SieckGC, FournierM, et al. The effect of nutritional deprivation of diaphragm contractility and muscle fiber size. J Appl Physiol1986;60:596–603.
76.
DoekelRC, ZwillichC, ScogginCH, KrygerM, WeilJV. Clinical semi-starvation: depression of hypoxic ventilatory response. N Engl J Med1976;295:358–361.
77.
BassiliHR, DeitelM.Effect of nutritional support on weaning patients off mechanical ventilators. J Parenter Enteral Nutr1981;5(2):161–163.
78.
LarcaL, GreenbaumDM. Effectiveness of intensive nutritional regimes in patients who fail to wean from mechanical ventilation. Crit Care Med1982;10:297–300.
79.
AubierM, MurcianoD, LecocguicY, et al. Effects of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. N Engl J Med1985;313:420–424.
80.
AubierM, ViiresN, PiquetJ, et al. Effects of hypocalcemia on diaphragmatic strength generation. J Appl Physiol1985;58:2054–2061.
81.
CerraF.Hypermetabolism, organ failure and metabolic support. Surgery1987;101:1–14.
82.
DhingraS, SolvenF, WilsonA, McCarthyDS. Hypomagnesemia and respiratory muscle power. Am Rev Respir Dis1984;129:497–498.
83.
ZwillichCW, PiersonDJ, HofeldtFD, et al. Ventilatory control in myxedema and hypothyroidism. N Engl J Med1975;292:662–665.
84.
SiafakasNM, SalesiotouV, FiladitakiV, et al. Respiratory muscle strength in hypothyroidism. Chest1992;102:189–194.
85.
MohsenifarZ, HayA, HayJ, LewisMI, KoernerSK. Gastric intramural pH as a predictor of success or failure in weaning patients from mechanical ventilation. Ann Int Med1993;119:794–798.
86.
BouachourG, GuiraudMP, GouelloJP, RoyPM, AlquierP.Gastric intramucosal pH: an indicator of weaning outcome from mechanical ventilation in COPD patients. Eur Respir J1996;9:1868–1873.
87.
BandoK, SunK, BinfordRS, et al. Determinants of longer duration of endotracheal intubation after adult cardiac operations. Ann Thor Surg1997;63:1026–1033.
88.
ArtigasA, BernardGR, CarletJ, et al. The American European Consensus Conference on ARDS, Part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Am J Respir Crit Care Med1998;157:1332–1347.
89.
JubranA, MathruM, DriesD, TobinMJ. Continuous recordings of mixed venous oxygen saturation during weaning from mechanical ventilation and the ramifications thereof. Am J Respir Crit Care Med1998;158:1763–1769.
90.
LemaireF, TeboulJ-L, CinottiL, GiottoG, AbroukF, StegG, et al. Acute left ventricular dysfunction during unsuccessful weaning from mechanical ventilation. Anesthesiology1988;69:171–179.
91.
EpsteinSK. Etiology of extubation failure and the predictive value of the rapid shallow breathing index. Am J Respir Crit Care Med1995;152:545–549.
92.
RichardCH, TeboulJL, ArchambaudF, et al. Left ventricular function during weaning of patients with chronic obstructive pulmonary disease. Intensive Care Med1994;20:181–186.
93.
ChatilaW, AniS, GuaglianoneD, et al. Cardiac ischemia during weaning from mechanical ventilation. Chest1996;109:1577–1583.
94.
NettLM, MorganrothM, PettyTL. Weaning from mechanical ventilation: a perspective and review of techniques. In: BoneRC, editor. Critical care: a comprehensive approach. Park Ridge IL: Am Coll Chest Phys; 1984;171–188.
95.
CooperKR, PhillipsBA. Effect of short-term sleep loss on breathing. J Appl Physiol1982;53:855–858.
96.
SpenglerCM, SheaSA. Sleep deprivation per se does not decrease the hypercapnic ventilatory response in humans. Am J Respir Crit Care Med2000;161:1124–1128.
97.
LaRicciaPJ, KatzRH, PetersJW, et al. Biofeedback and hypnosis in weaning from mechanical ventilators. Chest1985;87:267–269.
98.
HolidayJE, HyersTM. The reduction of weaning time from mechanical ventilation using tidal volume and relaxation feedback. Am Rev Respir Dis1990;141:1214–1220.
99.
TorresA, Serra-BatllesJ, RosE, et al. Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation: the effect of body position. Ann Int Med1992;116:540–543.
100.
EpsteinSK, CiubotaruRL, WongJB. Effect of failed extubation on the outcome of mechanical ventilation. Chest1997;112:186–192.
101.
EstebanA, AliaI, GordoF, FernandezR, SolsonaJF, VallverduI, et al. Extubation outcome after spontaneous breathing trials with T-tube or pressure support ventilation. The Spanish Lung Failure Collaborative Group. Am J Respir Crit Care Med1997;156(2 pt 1):459–465. [published erratum appears in Am J Respir Crit Care Med 1997;156(6):2028.]
102.
EstebanA, AliaI, TobinMJ, GilA, GordoF, VallverduI, et al. Effect of spontaneous breathing trial duration on outcome of attempts to discontinue mechanical ventilation. Spanish Lung Failure Collaborative Group. Am J Respir Crit Care Med1999;159(2):512–518.
103.
VallverduI, CalafN, SubiranaM, NetA, BenitoS, ManceboJ.Clinical characteristics, respiratory functional parameters, and outcome of a two-hour T-piece trial in patients weaning from mechanical ventilation. Am J Respir Crit Care Med1998;158:1855–1862.
104.
ElyEW, BakerAM, EvansGW, HaponikEF. The prognostic significance of passing a daily screen of breathing spontaneously. N Engl J Med1999;25:581–587.
105.
FagonJY, ChastreJ, HanceAJ, MontraversP, NovaraA, GibertC.Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am J Med1993;94:281–288.
106.
EpsteinSK, CiubotaruRL. Independent effects of etiology of failure and time to reintubation on outcome for patients failing extubation. Am J Respir Crit Care Med1998;158:489–493.
107.
EstebanA, FrutosF, TobinMJ, AliaI, SolsonaJF, ValverduI, et al. A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group. N Engl J Med1995;332:345–350.
108.
ElyEW, BakerAM, DunaganDP, BurkeHL, SmithAC, KellyPT, et al. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med1996;335:1864–1869.
109.
BrochardL, RaussA, BenitoS, ContiG, ManceboJ, RekikN, et al. Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med1994;150:896–903.
110.
DojatM, HarfA, TouchardD, LaforestM, LamaireF, BrochardL.Evaluation of a knowledge-based system providing ventilatory management and decision for extubation. Am J Respir Crit Care Med1996;153:997–1004.
111.
YangKL. Reproducibility of weaning parameters; a need for standardization. Chest1992;102:1829–1832.
112.
MultzAS, AldrichTK, PrezantDJ, KarpelJP, HendlerJM. Pmax is not a reliable test of inspiratory muscle strength in mechanically ventilated patients. Am Rev Respir Dis1990;142:529–532.
113.
BurnsSM, ClochesyJM, Goodnough-HannemanSK, et al. Weaning from long-term mechanical ventilation. Am J Crit Care Med1995;4:4–22.
114.
Goodnough-HannemanSK, IngersollGL, KnebelAR, et al. Weaning from short-term mechanical ventilation: a review. Am J Crit Care Med1994;3:421–443.
115.
JaeschkeR, GuyattG, SackettD, et al, for the Evidence-Based Medicine Working Group. Users' guide to the medical literature: how to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? JAMA 1994;271:703–707.
116.
JubranA, ParthasarathyS.Hypercapneic respiratory failure during weaning: neuromuscular capacity vs muscle loads. Respir Care Clin N Am2000;6:385–406.
117.
CapdevilaX, PerrigaultPF, RamonatxoM, RoustanJP, PerayP, d'AthisF, PrefautC.Changes in breathing pattern and respiratory muscle performance parameters during difficult weaning. Crit Care Med1998;26:79–87.
118.
VassilakopoulosT, ZakynthinosS, RoussosC.The tension-time index and the frequency/tidal volume ratio are the major pathophysiologic determinants of weaning failure and success. Am J Respir Crit Care Med1998;158:378–385.
119.
KollefMH, ShapiroSD, SilverP, PrenticeD, SauerS, AhrensTS, et al. A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation. Crit Care Med1997;25:567–574.
120.
ChopinC, ChambrinMC, MangalaboyiJ, LestavelP, FourrierF.Carbon dioxide mandatory ventilation (CO2MV): a new method for weaning from mechanical ventilation-description and comparative clinical study with I.M.V. and T. tube method in COPD patient. Int J Clin Monit Comput1989;6:11–19.
121.
StroetzRW, HubmayrRD. Tidal volume maintenance during weaning with pressure support. Am J Respir Crit Care Med1995;152:1034–1040.
122.
EngorenM, BudererNF, ZachariasA, HabibRH. Variables predicting reintubation after cardiac surgical procedures. Ann Thoracic Surg1999;67:661–665.
123.
RadyMY, RyanT.Perioperative predictors of extubation failure and the effect on clinical outcome after cardiac surgery. Crit Care Med1999;27:340–347.
124.
LondonMJ, ShroyerAL, CollJR, MaWhinneyS, FullertonDA, HammermeisterKE, GroverFL. Early extubation following cardiac surgery in a veterans population. Anesthesiology1998;88:1447–1458.
125.
deHavenCB, KirtonOC, MorganJP, HartAM, ShatzDV, CivettaJM. Breathing measurements reduces false negative classification of tachypneic pre-extubation trial failures. Crit Care Med1996;24:976–980.
126.
LaghiF, D'AlfonsoN, TobinMJ. Pattern of recovery from diaphragmatic fatigue over 24 hours. J Appl Physiol1995;79:539–546.
127.
ReidWD, HuangJ, BrysonS, WalkerDC, BelcastroAN. Diaphragm injury and myofibrillar structure induced by resistive loading. J Appl Physiol1994;76:176–184.
128.
CohenCA, ZagelbaumG, GrossD, RoussosC, MacklemPT. Clinical manifestations of inspiratory muscle fatigue. Am J Med1982;73:308–316.
129.
FeeleyTW, SaumarezR, KlickJM, McNabbTG, SkillmanJJ. Positive end-expiratory pressure in weaning patients from controlled ventilation: a prospective randomized trial. Lancet1975;2(7938):725–729.
130.
JonesDP, ByrneP, MorganC, FraserI, HylandR.Positive end-expiratory pressure vs T-piece: extubation after mechanical ventilation. Chest1991;100:1655–1659.
131.
BaileyCR, JonesRM, KelleherAA. The role of continuous positive airway pressure during weaning from mechanical ventilation in cardiac surgical patients. Anaesthesia1995;50:677–681.
132.
PetrofBJ, LegareM, GoldbergP, et al. Continuous positive airway pressure reduces work of breathing and dyspnea during weaning from mechanical ventilation in severe chronic obstructive pulmonary disease. Am Rev Respir Dis1990;141:281–289.
133.
SmithTC, MariniJJ. Impact of PEEP on lung mechanics and work of breathing in severe airflow obstruction. J Appl Physiol1988;65:1488–1497.
134.
FisherMM, RaperRF. The "cuff leak" test for extubation. Anaesthesia1992;47:10–12.
135.
MillerR, ColeR.Association between reduced cuff leak volume and postextubation stridor. Chest1996;110:1035–1040.
136.
EngorenM.Evaluation of the cuff leak test in cardiac surgery patients. Chest1999;116:1029–1031.
137.
CoplinWM, PiersonDJ, CooleyKD, NewellDW, ReubenfeldGD. Implications of extubation delay in brain injured patients meeting standard weaning criteria. Am J Respir Crit Care Med2000;161:1530–1536.
138.
CapdevilaXJ, PerrigaultPF, PereyPJ, RoustanJP, d'AthisF.Occlusion pressure and its ratio to maximum inspiratory pressure are useful predictors for successful extubation following T-piece weaning trial. Chest1995;108:482–489.
139.
BachJ, SaportoL.Criteria for extubation and tracheostomy tube removal for patients with ventilatory failure. Chest1996;110:1566–1571.
140.
TravalineJM, SudershanS, CrinerGJ. Recovery of Pdi twitch following the induction of diaphragm fatigue in normal subjects. Am J Respir Crit Care Med1997;156:1562–1566.
141.
JounieauxV, DuranA, Levi-ValensiP.Synchronized intermittent mandatory ventilation with and without pressure support ventilation in weaning patients with COPD from mechanical ventilation. Chest1994;105:1204–1210.
142.
EsenF, DenkelT, TelciL, KeseciogluJ, TutuncuAS, AkpirK, LachmannB.Comparison of pressure support ventilation (PSV) and intermittent mandatory ventilation (IMV) during weaning in patients with acute respiratory failure. Adv Exper Med Biol1992;317:371–376.
143.
HessD, BransonRD. Ventilators and weaning modes. Respir Care Clin N Am2000;6:407.
144.
StrausC, LouisB, IsabeyD, et al. Contribution of the endotracheal tube and the upper airway to breathing workload. Am J Respir Crit Care Med1998;157:23–30.
145.
IottiGA, OliveiMC, PaloA, et al. Unfavorable mechanical effects of heat and moisture exchangers in ventilated patients. Int Care Med1997;23:399–405.
146.
LeBourdellesG, MierL, FiquetB, et al. Comparison of the effects of heat and moisture exchangers and heated humidifiers on ventilation and gas exchange during weaning trials from mechanical ventilation. Chest1996;110:1294–1298.
147.
SassoonCSH. Mechanical ventilator design and function: the trigger variable. Respir Care1992;37:1056–1069.
148.
MacIntyreNR, HoL.Effects of initial flow rate and breath termination criteria on pressure support ventilation. Chest1991;99:134–138.
149.
MacIntyreNR, et al. Patient-ventilator flow dyssynchrony: flow limited versus pressure limited breaths. Crit Care Med1997;25:1671.
150.
BransonRD, CampbellRS, DavisK, et al. Altering flowrate during maximum pressure support ventilation (PSVmax): Effects on cardiorespiratory function. Respir Care1990;35:1056–1064.
151.
ImsandC, FeihlF, PerretC, FittingJW. Regulation of inspiratory neuromuscular output during synchronized intermittent mechanical ventilation. Anesthesiology1994;80:13–22.
152.
MariniJJ, SmithTC, LambVJ. External work output and force generation during synchronized intermittent mandatory ventilation: effect of machine assistance on breathing effort. Am Rev Respir Dis1988;138:1169–1179.
153.
ParthasarathyS, JubranA, TobinMJ. Cycling of inspiratory and expiratory muscle groups with the ventilator in airflow limitation. Am J Respir Crit Care Med1998;158:1471–1478.
154.
JubranA, van de GraaffWB, TobinMJU. Variability of patient-ventilator interaction with pressure support ventilation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med1995;152:129–136.
155.
BransonRD, MacIntyreNR. Dual-control modes of mechanical ventilation. Respir Care1996;41:294–305.
156.
LintonDM, PotgieterPD, DavisS, et al. Automatic weaning from mechanical ventilation using an adaptive lung controller. Chest1994;105:1843–1850.
157.
DojatM, HarfA, TouchardD, LeMaireF, BrochardL.Clinical evaluation of a computer controlled pressure support mode. Am J Respir Crit Care Med2000;161:1161–1166.
158.
DavisS, PotgieterPD, LintonDM. Mandatory minute volume weaning in patients with pulmonary pathology. Anaesth Int Care1989;17:170–174.
159.
GiraultC, DaudenthunI, ChevronV, TamionF, LeroyJ, BonmarehandG.Noninvasive ventilation as a systematic extubation and weaning technique in acute-on-chronic respiratory failure: a prospective, randomized controlled study. Am J Respir Crit Care Med1999;160:86–92.
160.
NavaS, AmbrosinoN, CliniE, PratoM, OrlandoG, VitaccaM, et al. Noninvasive mechanical ventilation in the weaning of patients with respiratory failure due to chronic obstructive pulmonary disease: a randomized, controlled trial. Ann Intern Med1998;128:721–728.
161.
ChengDC, KarskiJ, PenistonC, AsokumarB, RaveendranG, CarrollJ, et al. Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial. J Thor Cardiovasc Surg1996;112:755–764.
162.
BerryPD, ThomasSD, MahonSP, JacksonM, FoxMA, FabriB, et al. Myocardial ischaemia after coronary artery bypass grafting: early vs. late extubation. Br J Anaes1998;80:20–25.
163.
MichalopoulosA, NikolaidesA, AntzakaC, DeliyanniM, SmirliA, GeroulanosS, PapadimitriouL.Change in anaesthesia practice and postoperative sedation shortens ICU and hospital length of stay following coronary artery bypass surgery. Respir Med1998;92:1066–1070.
164.
SilbertBS, SantamariaJD, O'BrienJL, BlythCM, KellyWJ, MolnarRR. Early extubation following coronary artery bypass surgery: a prospective randomized controlled trial. The Fast Track Cardiac Care Team. Chest1998;113:1481–1488.
165.
EngorenMC, KrarasC, GarziaF.Propofol-based versus fentanyl-isoflurane-based anesthesia for cardiac surgery. J Cardiothorac Vasc Anesth1998;12:177–181.
166.
ShackfordSR, VirgilioRW, PetersRM. Early extubation versus prophylactic ventilation in the high risk patient: a comparison of postoperative management in the prevention of respiratory complications. Anesth Analg1981;60:76–80.
167.
TempeD, CooperA, MohanJC, NigamM, TomarAS, RameshK, et al. Closed mitral valvotomy and elective ventilation in the postoperative period: effect of mild hypercarbia on right ventricular function. J Cardiothorac Vasc Anesth1995;9:552–557.
168.
QuashaAL, LoeberN, FreeleyTW, UllyotDH, RoizenMF. Postoperative respiratory care: a controlled trial of early and late extubation following coronary artery bypass grafting. Anesthesiology1980;52:135–141.
169.
ReyesA, VegaG, BlancasR, MoratoB, MorenoJL, TorrecillaC, CereijoE.Early vs conventional extubation after cardiac surgery with cardiopulmonary bypass. Chest1997;112:193–201.
170.
DumasA, DupuisGH, SearleN, et al. Early versus late extubation after coronary artery bypass grafting: effects on cognitive function. J Cardiothorac Vasc Anesth1999;13:130–135.
171.
StollerJK, MaschaEJ, KesterL, HaneyDJ. Randomized controlled trial of physician-directed versus respiratory therapy consult service-directed respiratory care to adult non-ICU inpatients. Am J Respir Crit Care Med1998;158:1068–1075.
172.
MarelichGP, MurinS, BattistellaF, InciardiJ, VierraT, RobyM.Protocol weaning of mechanical ventilation in medical and surgical patients by respiratory therapists and nurses: effect on weaning time and incidence of ventilator-associated pneumonia. Chest2000;118;459–467.
173.
BrookAD, AhrensTS, SchaiffR, et al. Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation. Crit Care Med1999;27(12):2609–2615.
174.
KressJP, PohlmanAS, O'ConnorME, HallJB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342:1471–1477.
175.
ElyEW, NamenAM, TatterS, LuciaMA, SmithAC, LandryS, et al. Impact of a ventilator weaning protocol in neurosurgical patients: a randomized, controlled trial (abstract). Am J Respir Crit Care Med1999;159:A371.
176.
CollinGR, AtkinsonN, FurrowK, TrenisT, KeeleyRC, SedovyJD, et al. Decreasing the duration of mechanical ventilation through the use of a ventilation management protocol (abstract). Crit Care Med1999;27:A110.
177.
ElyEW, BennettPA, BowtonDL, MurphySM, HaponikEF. Large scale implementation of a respiratory therapist-driven protocol for ventilator weaning. Am J Respir Crit Care Med1999;159:439–446.
178.
FridkinSK, PearSM, WilliamsonTH, GalgianiJN, JarvisWR. The role of understaffing in central venous catheter-associated bloodstream infections. Infect Control Hosp Epidemiol1996;17:150–158.
179.
ArchibaldLK, ManningML, BellLM, BanedeeS, JarvisVTR. Patient density, nurse-to-patient ratio and nosocomial infection risk in a pediatric cardiac intensive care unit. Pediatr Infect Dis1997;16:1046–1048.
180.
ThorensJB, KaelinRM, JollietP, ChevroletJ-C. Influence of the quality of nursing on the duration of weaning from mechanical ventilation in patients with chronic obstructive pulmonary disease. Crit Care Med1995;23:1807–1815.
181.
PlummerAL, GraceyDR. Consensus conference on artificial airways in patients receiving mechanical ventilation. Chest1989;96:178–184.
182.
StaufferJL, OlsonDE, PettyTL. Complications and consequences of endotracheal intubation and tracheostomy: a prospective study of 150 critically ill adult patients. Am J Med1981;70:65–76.
183.
AstrachanDI, KirchnerJC, GoodwinWJJ. Prolonged intubation vs tracheostomy: complications, practical and psychological considerations. Laryngoscope1988;98:1165–1169.
184.
StockMC, WoodwardCG, ShapiroBA, et al. Perioperative complications of elective tracheostomy in critically ill patients. Crit Care Med1986;14:861–863.
185.
BoydSW, BenzelEC. The role of early tracheotomy in the management of the neurosurgical patient. Laryngoscope1992;102:559–562.
186.
HeffnerJE. Tracheotomy: indications and timing. Respir Care1999;44:807–815.
187.
HeffnerJE. Timing of tracheotomy in mechanically ventilated patients. Am Rev Respir Dis1993;147:768–771.
188.
ColiceGL, StukelTA, DainB.Laryngeal complications of prolonged intubation. Chest1989;96:877–884.
189.
WhitedRE. A prospective study of laryngotracheal sequelae in long-term intubation. Laryngoscope1984;94:367–377.
190.
KollefMH, LevyNT, AhrensTS, et al. The use of continuous intravenous sedation is associated with prolongation of mechanical ventilation. Chest1998;114:541–548.
191.
BerstenAD, RuttenAJ, VedigAE, et al. Additional work of breathing imposed by endotracheal tubes, breathing circuits, and intensive care ventilators. Crit Care Med1989;17:671–677.
192.
HabibM.Physiological implications of artificial airways. Chest1989;96:180–184.
193.
YungMW, SnowdonSL. Respiratory resistance of tracheostomy tubes. Arch Otolaryngol1984;110:591–595.
194.
WrightPE, MariniJJ, BernardGR. In vitro versus in vivo comparison of endotracheal tube airflow resistance. Am Rev Respir Dis1989;140:10–16.
195.
DiehlJL, El AtrousS, TouchardD, et al. Changes in the work of breathing induced by tracheotomy in ventilator-dependent patients. Am J Respir Crit Care Med1999;159:383–388.
196.
DavisKJr, CampbellRS, JohannigmanJA, et al. Changes in respiratory mechanics after tracheostomy. Arch Surg1999;134:59–62.
197.
LinMC, HuangCC, YangCT, et al. Pulmonary mechanics in patients with prolonged mechanical ventilation requiring tracheostomy. Anaesth Intensive Care1999;27:581–585.
198.
RodriguezJL, SteinbergSM, LuchettiFA, et al. Early tracheostomy for primary airway management in the surgical critical care setting. Surgery1990;108:655–659.
199.
DunhamMC, LaMonicaC.Prolonged tracheal intubation in the trauma patient. Trauma1984;24:120–124.
200.
SugermanHJ, WolfeL, PasqualeMD, et al. Multicenter, randomized, prospective trial of early tracheostomy. J Trauma1997;43:741–747.
201.
LesnikI, RappaportW, FulginitiJ, et al. The role of early tracheostomy in blunt, multiple organ trauma. Am Surg1992;58:346–349.
202.
BlotF, GuiguetM, AntounS, et al. Early tracheotomy in neutropenic, mechanically ventilated patients: rationale and results of a pilot study. Support Care Cancer1995;3:291–296.
203.
KohWY, LewTWK, ChinNM, et al. Tracheostomy in a neurointensive care setting: indications and timing. Anaesth Intensive Care1997;25:365–368.
204.
El-NaggarM, SadagopanS, LevineH, et al. Factors influencing choice between tracheostomy and prolonged translaryngeal intubation in acute respiratory failure: a prospective study. Anesth Analg1976;55:195–201.
205.
MaziakDE, MeadeMO, ToddTRJ. The timing of tracheotomy: a systematic review. Chest1998;114:605–609.
206.
SeneffMG, ZimmermanJE, KnausWA, et al. Predicting the duration of mechanical ventilation: the importance of disease and patient characteristics. Chest1996;110:469–479.
207.
KurekCK, CohenIL, LambrinosJ, et al. Clinical and economic outcome of patients undergoing tracheostomy for prolonged mechanical ventilation in New York State during 1993: analysis of 6,353 cases under diagnostic related group 483. Crit Care Med1997;25:983–988.
208.
ScheinhornDJ, ChaoDC, Steam-HassenpflugMA, et al. Post-ICU mechanical ventilation. Treatment of 1,123 patients at a regional weaning center. Chest1997;111:1654.
209.
ScheinhornDJ, ArtinianBA, CatlinJL. Weaning from prolonged mechanical ventilation: the experience at a regional weaning center. Chest1994;105:534.
210.
ScheinhornDJ, HassenpflugM, ArtinianB.Predictors of weaning after six weeks of mechanical ventilation. Chest1995;107:500.
211.
GraceyDR, HardyDC, NaessensJM, et al. The mayo ventilator-dependent rehabilitation unit: a 5-year experience. Mayo Clin Proc1997;72:13.
212.
ElpernEH, LarsonR, DouglassP, et al. Long-term outcomes for elderly survivors of prolonged ventilator assistance. Chest1989;96:1120–1124.
213.
IndiharFJ. A 10-year report of patients in a prolonged respiratory care unit. Minn Med1991;74:23–27.
214.
LatrianoB, McCauleyP, AstizME, et al. Non-ICU care of hemodynamically stable mechanically ventilated patients. Chest1996;109:1591.
215.
PetrakRA, NicholsonKI, BrofmanJD. Clinical outcomes prediction based on demographic data at a regional chronic ventilator-dependent unit. Program and abstracts of "Weaning '96," Weaning from prolonged mechanical ventilation. Palm Springs, 1996.
216.
ClarkRL, TheissD.Prolonged mechanical ventilation weaning, the experience at an extended critical care regional weaning center (abstract). Am J Respir Crit Care Med1997;155:A410.
217.
BagleyPH, CooneyE.A community-based regional ventilator weaning unit. Chest1997;111:1024–1029.
218.
CarsonSS, BachPB, BrzozowskiL, et al. Outcomes after long term acute care: an analysis of 133 mechanically ventilated patients. Am J Respir Crit Care Med1999;159:1568–1573.
219.
DasguptaA, RiceR, MaschaE, et al. Four-year experience with a unit for long-term ventilation (respiratory special care unit) at the Cleveland Clinic Foundation. Chest1999;116:447–455.
220.
GraceyDR, HardyDC, KoenigGE. Cost effective alternatives to intensive unit care: experience in the Mayo Rochester Chronic Ventilator Dependent Unit. Mayo Clin Proc2000;75:445–449.
221.
BurnsSM, MarshallM, BurnsJE, et al. Design, testing, and results of an outcomes-managed approach to patients requiring prolonged mechanical ventilation. Am J Crit Care1998;7:45–57.
222.
RubyEB, DaklyBJ, DouglasS, MontenegroHD, SongR, DyerMA. Patient outcomes for the chronically critically ill: special care vs intensive care unit. Nurs Res1995;44:324–331.
223.
ScheinhornDJ, ChaoDC, HassenpflugMS, et al. Post-ICU mechanical ventilation: results of a therapist-implemented patient-specific (TIPS) weaning protocol (abstract). Am J Respir Crit Care Med1999;159:A373.
224.
ScheinhornDJ, ChaoDC, HassenpflugMS. Approach to patients with long-term weaning failure. Respir Care Clin N Am2000;6:437–461.