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Abstract

Objective

Measure the fraction of inspired oxygen (F_IO₂) in infants receiving supplemental oxygen via nasal cannula and identify clinical variables that affect F_IO₂.

Methods

Hypopharyngeal gas samples were obtained from 20 infants receiving oxygen via nasal cannula at flows between 0 and 4 L/min. F_IO₂ was calculated using the alveolar gas equation and measurements of partial pressure of oxygen in the samples and the barometric pressure.

Results

F_IO₂ increased as oxygen flow was increased. F_IO₂ exceeded safe levels (> 60%) in two thirds of samples when the oxygen flow was 2 L/min or higher. Tachypnea (respiratory rate > 40 breaths/min) was associated with lower F_IO₂.

Conclusion

Infants receiving oxygen via nasal cannula at ≥ 2 L/min may be at risk for hyperoxic lung injury. Therefore, we recommend using the lowest possible oxygen flow needed to maintain normoxia in infants requiring prolonged oxygen therapy via nasal cannula.

Keywords

respiratory therapy lung injury free radicals oxygen toxicity hyperoxia respiratory failure pediatrics

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The Fraction of Inspired Oxygen in Infants Receiving Oxygen via Nasal Cannula Often Exceeds Safe Levels

Abstract

Objective

Methods

Results

Conclusion

Keywords

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References