Many techniques are available to evaluate oxygenation. These include arterial blood gases, capillary blood gases, point-of-care testing, blood gas monitors, pulse oximetery, transcutaneous blood gases, mixed venous blood gases, venous oximetry, and gastric tonometry. Clinicians should understand not only the benefits, but also the limitations of these techniques. Monitoring of oxygenation should not be done just because it is technically feasible. The decision to monitor, like any other clinical decision, should be based on therapeutic objectives.
HessD, KacmarekRM. Techniques and devices for monitoring oxygenation. Respir Care1993;38(6):646–669; discussion 669-671.
2.
EvansTW. Clinical assessment of the respiratory system. In: TobinMJ. Principles and practice of intensive care monitoring. New York: McGraw Hill; 1998.
3.
ClarkLCJr, ClarkEW. A personalized history of the Clark oxygen electrode. Inter Anesthiol Clin1987;25(3):1–29.
4.
AARC Clinical Practice Guideline. Sampling for arterial blood gas analysis. Respir Care1992;37(8):913–917.
5.
RaffinTA. Indications for arterial blood gas analysis. Ann Intern Med1986;105(3):390–398.
6.
MuakkassaFF, RutledgeR, FakhrySM, MeyerAA, SheldonGF. ABGs and arterial lines: the relationship to unnecessarily drawn arterial blood gas samples. J Trauma1990;30(9):1087–1095.
7.
SmollerBR, KruskallMS. Phlebotomy for diagnostic laboratory tests in adults: pattern of use and effect on transfusion requirements. N Engl J Med1986;314(19):1233–1235.
8.
LowLL, HarringtonGR, StoltzfusDP. The effect of arterial lines on blood-drawing practices and costs in intensive care units. Chest1995;108(1):216–219.
9.
ZimmermanJE, SeneffMG, SunX, WagnerDP, KnausWA. Evaluating laboratory usage in the intensive care unit: patient and institutional characteristics that influence frequency of blood sampling. Crit Care Med1997;25(5):737–748.
10.
CorwinHL, ParsonnetKC, GettingerA.RBC transfusion in the ICU: is there a reason?Chest1995;108(3):767–771.
11.
PeruzziWT, ParkerMA, LichtenthalPR, Cochran-ZullC, TothB, BlakeM.A clinical evaluation of a blood conservation device in medical intensive care unit patients. Crit Care Med1993;21(4):501–506.
12.
SilverMJ, JubranH, SteinS, McSweeneyT, JubranF.Evaluation of a new blood-conserving arterial line system for patients in intensive care units. Crit Care Med1993;21(4):507–511.
13.
SilverMJ, LiYH, GraggLA, JubranF, StollerJK. Reduction of blood loss from diagnostic sampling in critically ill patients using a blood-conserving arterial line system. Chest1993;104(6):1711–1715.
14.
PeruzziWT, NoskinGA, MoenSG, YungbluthM, LichtenthalP, ShapiroBA. Microbial contamination of blood conservation devices during routine use in the critical care setting: results of a prospective, randomized trial. Crit Care Med1996;24(7):1157–1162.
15.
FoulkeGE, HarlowDJ. Effective measures for reducing blood loss from diagnostic laboratory tests in intensive care unit patients. Crit Care Med1989;17(11):1143–1145.
16.
BeasleyKE, DarinJM, DurbinCGJr. The effect of respiratory care department management of a blood gas analyzer on the appropriateness of arterial blood gas utilization. Respir Care1992;37(4):343–347.
17.
PilonCS, LeathleyM, LondonR, McCleanS, PhangPT, PriestlyR, . Practice guideline for arterial blood gas measurement in the intensive care unit decreases numbers and increases appropriateness of tests. Crit Care Med1997;25(8):1308–1313.
18.
HessD, AgarwalNN. Variability of blood gases, pulse oximeter saturation, and end-tidal carbon dioxide pressure in stable, mechanically ventilated trauma patients. J Clin Monit1992;8(2):111–115.
19.
ThorsonSH, MariniJJ, PiersonDJ, HudsonLD. Variability of arterial blood gas values in stable patients in the ICU. Chest1983;84(1):14–18.
20.
SasseSA, ChenPA, MahutteCK. Variability of arterial blood gas values over time in stable medical ICU patients. Chest1994;106(1):187–193.
21.
TsaiYH, LinMC, HsiehMJ, ChenNH, TsaoTC, LeeCN, HuangCC. Spontaneous variability of arterial oxygenation in critically ill mechanically ventilated patients. Intensive Care Med1999;25(1):37–43.
22.
HessD, GoodC, DidyoungR, AgarwalNN, RexrodeWO. The validity of assessing arterial blood gases 10 minutes after an F1O2 change in mechanically ventilated patients without chronic pulmonary disease. Respir Care1985;30(12):1037–1041.
23.
MathewsPJJr. CO-oximetry (review). Respir Care Clin N Am1995;1(1):47–68.
24.
HessD, ElserRC, AgarwalNN. The effects on the pulmonary shunt value of using measured versus calculated hemoglobin oxygen saturation and of correcting for the presence of carboxyhemoglobin and methemoglobin. Respir Care1984;29(10):1001–1005.
25.
HessD, MaxwellC, ShefetD.Determination of intrapulmonary shunt: comparison of an estimated shunt equation and a modified equation with the classic equation. Respir Care1987;32(4):268–273.
26.
CohnJD, EnglerPE. Shunt effect of carboxyhemoglobin. Crit Care Med1979;7(2):54–58.
27.
CaneRD, ShapiroBA, HarrisonRA, SteinerMC, KavanaughJ.Minimizing errors in intrapulmonary shunt calculations. Crit Care Med1980;8(5):294–297.
28.
ZijlstraWG, BuursmaA, Meeuwsen-van der RoestWP. Absorption spectra of human fetal and adult oxyhemoglobin, de-oxyhemoglobin, carboxyhemoglobin, and methemoglobin. Clin Chem1991;37(9):1633–1638.
29.
MahoneyJJ, WongRJ, VremanHJ, StevensonDK. Fetal hemoglobin of transfused neonates and spectrophotometric measurements of oxyhemoglobin and carboxyhemoglobin. J Clin Monit1991;7(2):154–160.
30.
CornelissenPJH, van WoenselCLM, van OelWC, de JongPA. Correction factors for hemoglobin derivatives in fetal blood, as measured with the IL 282 CO-oximeter. Clin Chem1983;29(8):1555–1556.
31.
SehgalLR, SehgalHL, RosenAL, GouldSA, MossGS. Effect of Intralipid on measurements of total hemoglobin and oxyhemoglobin in whole blood. Crit Care Med1984;12(10):907–909.
32.
AARC Clinical Practice Guideline. Capillary blood gas sampling for neonatal & pediatric patients. Respir Care1994;39(12):1180–1183.
33.
PitkinAD, RobertsCM, WedzichaJA. Arterialized earlobe blood gas analysis: an underused technique. Thorax1994;49(4):364–366.
34.
DarK, WilliamsT, AitkenR, WoodsKL, FletcherS.Arterial versus capillary sampling for analysing blood gas pressures. BMJ1995;310(6971):24–25.
35.
SautyA, UldryC, DebetazLF, LevenbergerP, FittingJW. Differences in Po2 and Pco2 between arterial and arterialized earlobe samples. Eur Respir J1996;9(2):186–189.
36.
HughesJMB. Blood gas estimations from arterialized capillary blood versus arterial puncture: are they different?Eur Respir J1996;9(2):184–185.
37.
GinerJ, CasanP, BeldaJ, GonzalezM, MiraldaRM, SanchisJ.Pain during arterial puncture. Chest1996;110(6):1443–1445.
38.
HarveyMA. Point-of-care laboratory testing in critical care. Am J Crit Care1999;8(2):72–83.
39.
CastroHJ, OropelloJM, HalpernN.Point-of-care testing in the intensive care unit: the intensive care physician's perspective. Am J Clin Pathol1995;104(4 Suppl 1):S95–S99.
SmithBL, VenderJS. Point-of-care testing. Respir Care Clin N Am1995;1(1):133–141.
42.
ShapiroBA. Point-of-care blood testing and cardiac output measurement in the intensive care unit. New Horiz1999;7:244–252.
43.
ZalogaGP, HillTR, StricklandRA, KennedyD, VisserM, FordK, . Bedside blood gas and electrolyte monitoring in critically ill patients. Crit Care Med1989;17(9):920–925.
44.
ZalogaGP, DudasL, RobertsP, BortenschlagerL, BlackK, PrielippR.Near-patient blood gas and electrolyte analyses are accurate when performed by non-laboratory-trained individuals. J Clin Monit1993;9(5):341–346.
45.
HicksJM. Near patient testing: is it here to stay?J Clin Pathol1996;49(3):191–193.
46.
ZalogaGP, RobertsPR, BlackK, SantemauroJT, KlaseE, SuleimanM.Hand-held blood gas analyzer is accurate in the critical care setting. Crit Care Med1996;24(6):957–962.
47.
MacIntyreNR, LawlorB, CarstensD, YetskoD.Accuracy and precision of a point-of-care blood gas analyzer incorporating optodes. Respir Care1996;41(9):800–804.
48.
WahrJA, LauW, TremperKK, HallockL, SmithK.Accuracy and precision of a new, portable, handheld blood gas analyzer, the IRMA. J Clin Monit1996;12(4):317–324.
49.
ShelledyDC, SmithWA. A comparison of the i-STAT system and Corning 278 for the measurement of arterial blood gas values. Respir Care1997;42(7):693–697.
50.
MurthyJN, HicksJM, SoldinSJ. Evaluation of the i-STAT portable clinical analyzer in a neonatal and pediatric intensive care unit. Clin Biochem1997;30(5):385–389.
51.
KendallJ, ReevesB, ClancyM.Point of care testing: randomised controlled trial of clincial outcome. BMJ1998;316(7137):1052–1057.
52.
KeeferJH. Economic considerations of point-of-care testing. Am J Clin Pathol1995;104(4 Suppl 1):S107–S110.
53.
ShapiroBA. In-vivo monitoring of arterial blood gases and pH. Respir Care1992;37(2):165–169.
54.
PeruzziWT, ShapiroBA. Blood gas monitors. Respir Care Clin N Am1995;1(1):143–156.
55.
ShapiroBA. Clinical and economic performance criteria for intraarterial and extraarterial blood gas monitors, with comparison with in vitro testing. Am J Clin Pathol1995;104(4 Suppl 1):S100–S106.
MillerWW, GehrichJL, HansmannDR, YafusoM.Continuous in vivo monitoring of blood gases. Lab Med1988;19:629–635.
58.
BarkerSJ, TremperKK. Intra-arterial oxygen tension monitoring. Int Anesthiol Clin1987;25(3):199–208.
59.
LübbersDW. Oxygen electrodes and optodes and their application in vivo. Adv Exp Med Biol1996;388:13–34.
60.
OpitzN, LübbersDW. Theory and development of fluorescence-based optochemical oxygen sensors: oxygen optodes. Int Anesthesiol Clin1987;25(3):177–197.
61.
ShapiroBA, CaneRD, ChomkaCM, BandalaLE, PeruzziWT. Preliminary evaluation of an intra-arterial blood gas system in dogs and humans. Crit Care Med1989;17(5):455–460.
62.
ZimmermanJL, DellingerRP. Initial evaluation of a new intra-arterial blood gas system in humans. Crit Care Med1993;21(4):495–500.
63.
ShapiroBA, MahutteCK, CaneRD, GilmourIJ. Clinical performance of a blood gas monitor: a prospective, multicenter trial. Crit Care Med1993;21(4):487–494.
64.
MahutteCK, SasseSA, ChenPA, HolodyM.Performance of a patient-dedicated, on-demand blood gas monitor in medical ICU patients. Am J Respir Crit Care Med1994;150(3):865–869.
65.
HallerM, KilgerE, BreigelJ, ForstH, PeterK.Continuous intra-arterial blood gas and pH monitoring in critically ill patients with severe respiratory failure: a prospective, criterion standard study. Crit Care Med1994;22(4):580–587.
66.
VenkateshB, Clutton BrockTH, HendrySP. A multiparameter sensor for continuous intra-arterial blood gas monitoring: a prospective evaluation. Crit Care Med1994;22(4):588–594.
67.
LarsonCPJr, VenderJ, LeiverA.Multisite evaluation of a continuous intraarterial blood gas monitoring system. Anesthesiology1994;81(3):543–552.
68.
VenkateshB, Clutton-BrockTH, HendrySP. Evaluation of the Paratrend 7 intravascular blood gas monitor during cardiac surgery: comparison with the C4000 in-line blood gas monitor during cardiopulmonary bypass. J Cardiothorac Vasc Anesth1995;9(4):412–419.
69.
KurahashiK, HiroseY, YamadaH, ToyoshimaM, UsudaY.Intraarterial blood gas monitoring system: more accurate values can be obtained. J Clin Monit1996;12(2):141–147.
70.
FranklinML, PeruzziWT, MoenSG, ShapiroBA. Evaluation of an on-demand, ex vivo bedside blood gas monitor on pulmonary artery blood gas determinations. Anesth Analg1996;83(3):500–504.
71.
WeissIK, FinkS, HarrisonR, DonnellyK.Continuous arterial gas monitoring: initial experience with the Paratrend 7 in children. Intensive Care Med1996;22(12):1414–1417.
72.
AbrahamE, GallagherTJ, FinkS.Clinical evaluation of a multiparameter intra-arterial blood-gas sensor. Intensive Care Med1996;22(5):507–513.
73.
McKinleyBA, ParmleyCL. Clinical trial of an ex vivo arterial blood gas monitor. J Crit Care1998;13(4):190–197.
74.
BaileyPL, McJamesSW, CluffL, WellsDT, OrrJA, WestenskowDR, KernSE. Evaluation in volunteers of the VIA V-ABG automated bedside blood gas, chemistry, and hematocrit monitor. J Clin Monit Comput1998;14(5):339–346.
75.
WeissIK, FinkS, HarrisonR, . Clinical use of continuous arterial blood gas monitoring in the pediatric intensive care unit. Pediatrics1999;103:440–445.
76.
MorganC, NewellSJ, DuckerDA, FeldmanJD, BrillJE. Continuous neonatal blood gas monitoring using a multiparameter intra-arterial sensor. Arch Dis Child Fetal Neonatal Ed1999;80(2):F93–F98.
77.
SeveringhausJW, KelleherJF. Recent developments in pulse oximetry. Anesthesiology1992;76(6):1018–1038.
HanningCD, Alexander-WilliamsJM. Pulse oximetry: a practical review. BMJ1995;311(7001):367–370.
86.
MoyleJTB. Uses and abuses of pulse oximetry. Arch Dis Child1996;74(1):77–80.
87.
JensenLA, OnyskiwJE, PrasadNGN. Meta-analysis of arterial oxygen saturation monitoring by pulse oximetry in adults. Heart Lung1998;27(6):387–408.
88.
AvantMG, LoweN, TorresAJr. Comparison of accuracy and signal consistency of two reusable pulse oximeter probes in critically ill children. Respir Care1997;42(7):698–704.
89.
RusselGB, GraybealJM. Accuracy of laminated disposable pulse-oximeter sensors. Respir Care1995;40(7):728–733.
90.
GerberDR, SantarelliRJ, ScottWE, KernME, DuBoisJM. Evaluation of a protective sheath for disposable pulse oximetry probes. Respir Care1996;41(3):197–201.
91.
SalyerJW, BurtonK, LynchJ, BallardJ, KeenanJ.Adventures in recycling: the reuse of "disposable" pulse oximeter probes (editorial). Respir Care1993;38(10):1072–1076.
92.
ReynoldsKJ, PalayiwaE, MoyleJTB, SykesMK, HahnCE. The effect of dyshemoglobins on pulse oximetry: Part I. Theoretical approach and Part II. Experimental results using an in vitro test system. J Clin Monit1993;9(2):81–90.
93.
RalstonAC, WebbRK, RuncimanWB. Potential errors in pulse oximetry. I. Pulse oximeter evaluation. Anaethesia1991;46(3):202–206.
94.
WebbRK, RalstonAC, RuncimanWB. Potential errors in pulse oximetry. II. Effects of changes in saturation and signal quality. Anaesthesia1991;46(3):207–212.
95.
RalstonAC, WebbRK, RuncimanWB. Potential errors in pulse oximetry. III. Effects of interference, dyes, dyshaemoglobins and other pigments. Anaesthesia1991;46(4):291–295.
96.
CarlinBW, ClausenJL, RiesAL. The use of cutaneous oximetry in the prescription of long-term oxygen therapy. Chest1988;94(2):239–241.
97.
VolskoTA, ChatburnRL, KallstromTJ. Evaluation of a commercial standard for checking pulse oximeter performance. Respir Care1996;41(2):100–104.
98.
StonehamMD, SavilleGM, WilsonIH. Knowledge about pulse oximetry among medical and nursing staff. Lancet1994;344(8933):1339–1342.
99.
ChoeH, TashiroC, FukumitsuK, YagiM, YoshiyaI.Comparison of recorded values from six pulse oximeters. Crit Care Med1989;17(7):678–681.
100.
TaylorMB, WhitwamJG. The accuracy of pulse oximeters: a comparative clinical evaluation of five pulse oximeters. Anaesthesia1988;43(3):229–232.
101.
HannhartB, MichalskiH, DelormeN, ChapparoG, PuluJM. Reliability of six pulse oximeters in chronic obstructive pulmonary disease. Chest1991;99(4):842–846.
102.
SeveringhausJW, NaifehKH, KohSO. Errors in 14 pulse oximeters during profound hypoxia. J Clin Monit1989;5(2):72–81.
103.
SeveringhausJW, NaifehKH. Accuracy of response of six pulse oximeters to profound hypoxia. Anesthesiology1987;67(4):551–558.
104.
HannhartB, HabererJP, SaunierC, LaxenaireMC. Accuracy and precision of fourteen pulse oximeters. Eur Respir J1991;4(1):115–119.
105.
KelleherJF, RuffRH. The penumbra effect: vasomotion-dependent pulse oximeter artifact due to probe malposition. Anesthesiology1989;71(5):787–791.
106.
VegforsM, LennmarkenC.Carboxyhaemoglobinaemia and pulse oximetry. Br J Anaesth1991;66(5):625–626.
107.
BarkerSJ, TremperKK. The effect of carbon monoxide inhalation on pulse oximetry and transcutaneous Po2. Anesthesiology1987;66(5):677–679.
108.
RaemerDB, ElliottWR, TopulosGP, PhilipJH. The theoretical effect of carboxyhemoglobin on the pulse oximeter. J Clin Monit1989;5(4):246–249.
109.
HampsonNB. Pulse oximetry in severe carbon monoxide poisoning. Chest1998;114(4):1036–1041.
110.
BarkerSJ, TremperKK, HyattJ.Effects of methemoglobinemia on pulse oximetry and mixed venous oximetry. Anesthesiology1989;70(1):112–117.
111.
HarrisAP, SendakMJ, DonhamRT, ThomasM, DuncanD.Absorption characteristics of human fetal hemoglobin at wavelengths used in pulse oximetry. J Clin Monit1988;4(3):175–177.
112.
KressJP, PohlmanAS, HallJB. Determination of hemoglobin saturation in patients with acute sickle chest syndrome: a comparison of arterial blood gases and pulse oximetry. Chest1999;115(5):1316–1320.
113.
ScottDM, CooperMG. Spurious pulse oximetry with intrauterine methylene blue injection. Anaesth Intens Care1991;19(2):267–268.
114.
SchellerMS, UngerRJ, KelnerMJ. Effects of intravenously administered dyes on pulse oximeter readings. Anesthesiology1986;65(5):550–552.
115.
CoteCJ, GoldsteinEA, FuchsmanWH, HoaglinDC. The effect of nail polish on pulse oximetry. Anesth Analg1988;67(7):683–686.
116.
VeyckemansF, BaeleP, GuillaumeJE, WillemsE, RobertA, ClerbauxT.Hyperbilirubinemia does not interfere with hemoglobin saturation measured by pulse oximetry. Anesthesiology1989;70(1):118–122.
117.
ChelluriL, SnyderJV, BirdJR.Accuracy of pulse oximetry in patients with hyperbilirubinemia. Respir Care1991;36(12):1383–1386.
118.
ZeballosRJ, WiesmanIM. Reliability of noninvasive oximetry in black subjects during exercise and hypoxia. Am Rev Respir Dis1991;144(6):1240–1244.
119.
JubranA, TobinMJ. Reliability of pulse oximetry in titrating supplemental oxygen therapy in ventilator-dependent patients. Chest1990;97(6):1420–1425.
120.
CahanC, DeckerMJ, HoekjePL, StrohlKP. Agreement between noninvasive oximetric values for oxygen saturation. Chest1990;97(4):814–819.
121.
SeveringhausJW, KohSO. Effect of anemia on pulse oximeter accuracy at low saturation. J Clin Monit1990;6(6):85–88.
122.
LeeS, TremperKK, BarkerSJ. Effects of anemia on pulse oximetry and continuous mixed venous hemoglobin saturation monitoring in dogs. Anesthesiology1991;75(1):118–122.
123.
DumasC, WahrJA, TremperKK. Clinical evaluation of a prototype motion artifact resistant pulse oximeter in the recovery room. Anesth Analg1996;83(2):269–272.
124.
SamiHM, KleinmanBS, LonchynaVA. Central venous pulsations associated with a falsely low oxygen saturation measured by pulse oximetry. J Clin Monit1991;7(4):309–312.
125.
WilkinsCJ, MooresM, HanningCD. Comparison of pulse oximeters: effects of vasoconstriction and venous engorgement. Br J An-aesth1989;62(4):439–444.
126.
StewartKG, RowbottomSJ. Inaccuracy of pulse oximetry in patients with severe tricuspid regurgitation. Anaesthesia1991;46(8):668–670.
127.
ChemelloPD, NelsonSR, WolfordLM. Finger injury resulting from pulse oximeter probe during orthognathic surgery. Oral Surg Oral Med Oral Pathol1990;69(2):161–163.
128.
MurphyKG, SecundaJA, RockoffMA. Severe burns from a pulse oximeter. Anesthesiology1990;73(2):350–352.
129.
StognerSW, OwensMW, BaethgeBA. Cutaneous necrosis and pulse oximetry. Cutis1991;48(3):235–137.
130.
BasheinG, SyrovyG.Burns associated with pulse oximetry during magnetic resonance imaging. Anesthesiology1991;75(2):382–383.
131.
InmanKJ, SibbaldWJ, RutledgeFS, SpeechleyM, MartinCM, ClarkBJ. Does implementing pulse oximetry in a critical care unit result in substantial arterial blood gas savings?Chest1993;104(2):542–546.
132.
KellermanAL, CoferCA, JosephS, HackmanBB. Impact of portable pulse oximetry on arterial blood gas test ordering in an urban emergency department. Ann Emerg Med1991;20(2):130–134.
133.
MowerWR, SachsC, NicklinEL, SafaP, BaraffLJ. Effect of routine emergency department triage pulse oximetry screening on medical management. Chest1995;108(5):1297–1302.
134.
Le BourdellesG, EstagnasieP, LenoirF, BrunP, DreyfussD.Use of pulse oximeter in an adult emergency department: impact on the number of arterial blood gas analyses ordered. Chest1998;113(4):1042–1047.
135.
BowtonDL, ScuderiPE, HarrisL, HaponikEF. Pulse oximetry monitoring outside the intensive care unit: progress or problem?Ann Intern Med1991;115(6):450–454.
136.
MollerJT, PedersenT, RasmussenLS, JensenPF, PedersenBD, RavloO, et al. Randomized evaluation of pulse oximetry in 20,802 patients. 1. Design, demography, pulse oximetry failure rate, and overall complication rate. Anesthesiology1993;78(3):436–444.
137.
MollerJT, JohannessenNW, EspersenK, RavloO, PedersenBD, JensenPF, et al. Randomized evaluation of pulse oximetry in 20,802 patients. II. Perioperative events and postoperative complications. Anesthesiology1993;78(3):445–453.
138.
LawlessST. Crying wolf: false alarms in a pediatric intensive care unit. Crit Care Med1994;22(6):981–985.
139.
TseinCL, FacklerJC. Poor prognosis for existing monitors in the intensive care unit. Crit Care Med1997;25(4):614–619.
140.
BenttLR, SantoraTA, LaverleBJ, LoBueM, ShabotMM. Accuracy and utility of pulse oximetry in the surgical intensive care unit. Curr Surg1990;47(4):267–268.
141.
KestinIG, MillerBR, LockhartCH. Auditory alarms during anesthesia monitoring. Anesthesiology1988;69(1):106–109.
142.
FreundPR, OverandPT, CooperJ, JacobsonL, BosseS, WalkerB, et al. A prospective study of intraoperative pulse oximetry failure. J Clin Monit1991;7(3):253–258.
143.
CarterB, HochmannM, OsborneA, NisbetA, CampbellN.A comparison of two transcutaneous monitors for the measurement of arterial PO2 and PCO2 in neonates. Anaesth Intensive Care1995;23(6):708–714.
144.
AARC Clinical Practice Guideline. Transcutaneous blood gas monitoring for neonatal and pediatric patients. Respir Care1994;39(12):1176–1179.
LübbersDW. Theory and development of transcutaneous oxygen pressure measurement. Int Anesthesiol Clin1987;25(3):31–65.
147.
TremperKK, BarkerSJ. Transcutaneous oxygen measurement: experimental studies and adult applications. Int Anesthesiol Clin1987;25(3):67–96.
148.
KestenS, ChapmanKR, RebuckAS. Response characteristics of a dual transcutaneous oxygen/carbon dioxide monitoring system. Chest1991;99(5):1211–1215.
149.
HasibederW, HaisjacklM, SparrH, KlaunzerS, HormanC, SalakN, et al. Factors influencing transcutaneous oxygen and carbon dioxide measurements in adult intensive care patients. Intensive Care Med1991;17(5):272–275.
150.
PalmisanoBW, SeveringhausJW. Transcutaneous Pco₂ and Po₂: a multicenter study of accuracy. J Clin Monit1990;6(3):189–195.
151.
PadbergFT, BackTL, ThompsonPN, HobsonRW2nd. Transcutaneous oxygen (TcPO2) estimates probability of healing in the ischemic extremity. J Surg Res1996;60(2):365–369.
152.
TremperKK, ShoemakerWC. Transcutaneous oxygen monitoring of critically ill adults, with and without low flow shock. Crit Care Med1981;9(10):706–709.
153.
TremperKK, WaxmanK, BowmanR, ShoemakerWC. Continuous transcutaneous oxygen monitoring during respiratory failure, cardiac decompensation, cardiac arrest, and CPR: transcutaneous oxygen monitoring during arrest and CPR. Crit Care Med1980;8(7):377–381.
154.
AbrahamE, SmithM, SilverL.Continuous monitoring of critically ill patients with transcutaneous oxygen and carbon dioxide and conjunctival oxygen sensors. Ann Emerg Med1984;13(11):1021–1026.
155.
WaxmanK, SadlerR, EisnerME, ApplebaumR, TremperKK, MasonGR. Transcutaneous oxygen monitoring of emergency department patients. Am J Surg1983;146(1):35–38.
156.
AbrahamE, SmithM, SilverL.Conjunctival and transcutaneous oxygen monitoring during cardiac arrest and cardiopulmonary resuscitation. Crit Care Med1984;12(5):419–421.
157.
AbrahamE, EhrlichH.Conjunctival and transcutaneous oxygen monitoring during resuscitation. Ann Emerg Med1984;13(4):287–289.
158.
DantzkerDR. Oxygen transport and utilization. Respir Care1988;33(10):874–880.
KasnitzP, DrugerGL, YorraF, SimmonsDH. Mixed venous oxygen tension and hyperlactatemia: survival in severe cardiopulmonary disease. JAMA1976;236(6):570–574.
161.
SuterPM, LindauerJM, FairleyHB, SchlobohmRM. Errors in data derived from pulmonary artery blood gas values. Crit Care Med1975;3(5):175–181.
162.
MihmF, FeeleyTW, RosenthalM, RaffinTA. The lack of effect of variable blood withdrawal rates on the measurement of mixed venous oxygen saturation. Chest1980;78(3):452–455.
163.
NelsonRD, WilkinsRL, JacobsenWK, SheldonRL. Supranormal PVO2 in the presence of tissue hypoxia: a case report. Respir Care1983;28(2):191–194.
164.
NelsonRD. Continuous venous oximetry in surgical patients. Ann Surg1986;203(3):329–333.
165.
TahvanainenJ, MeretojaO, NikkiP.Can central venous blood replace mixed venous blood samples?Crit Care Med1982;10(11):758–761.
166.
SchweissJF. Mixed venous hemoglobin saturation: theory and application. Inter Anesthesiol Clin1987;25(3):113–136.
167.
PaulusDA. Invasive monitoring of respiratory gas exchange: continuous measurement of mixed venous oxygen saturation. Respir Care1987;32(7):535–541; discussion 541–543.
168.
FaheyPJ, HarrisK, Van derwarfC.Clinical experience with continuous monitoring of mixed venous oxygen saturation in respiratory failure. Chest1984;86(5):748–752.
169.
BarakaA, BaroodyM, HarounS, NawfalM, DabbousA, SibaiA, et al. Continuous venous oximetry during cardiopulmonary bypass: influence of temperature changes, perfusion flow, and hematocrit levels. J Cardiothorac Anesth1990;4(1):35–38.
HowdieshellTR, SussmanA, DipiroJ, McCartenM, MansbergerAJr. Reliability of in vivo mixed venous oximetry during experimental hypertriglyceridemia. Crit Care Med1992;20(7):999–1004.
172.
RoubyJJ, PoeteP, BodinL, BourgeoisJL, ArthaudM, ViarsP.Three mixed venous saturation catheters in patients with circulatory shock and respiratory failure. Chest1990;98(4):954–958.
173.
BaelePL, McMichanJC, MarshHM, SillJC, SouthornPA. Continuous monitoring of mixed venous oxygen saturation in critically ill patients. Anesth Analg1982;61(6):513–517.
174.
WallerJL, KaplanJA, BaumanDI, CraverJM. Clinical evaluation of a new fiberoptic catheter oximeter during cardiac surgery. Anesth Analg1982;61(8):676–679.
175.
GettingerA, DeTragliaMC, GlassDD. In vivo comparison of two mixed venous saturation catheters. Anesthesiology1987;66(3):373–375.
176.
KarisJH, LumbPD. Clinical evaluation of the Edwards Laboratories and Oximetrix mixed venous oxygen saturation catheters. J Cardiothorac Anesth1988;2:440–444.
177.
DivertieMB, McMichanJC. Continuous monitoring of mixed venous oxygen saturation. Chest1984;85(3):423–428.
178.
ReinhartK, MoserN, RudolphT, BredleD, SpechtM, GrammHJ, et al. Accuracy of two mixed venous saturation catheters during long-term use in critically ill patients. Anesthesiology1988;69(5):769–773.
179.
HeckerBR, BrownDL, WilsonD.A comparison of two pulmonary artery mixed venous oxygen saturation catheters during the changing conditions of cardiac surgery. J Cardiothorac Anesth1989;3(3):269–275.
180.
SchranzD, SchmittS, OelertH, SchmidF, HuthR, ZimmerB, et al. Continuous monitoring of mixed venous oxygen saturation in infants after cardiac surgery. Intensive Care Med1989;15(4):228–232.
181.
van WoerkensECSM, TrouwborstA, TenbrinckR.Accuracy of mixed venous saturation catheter during acutely induced changes in hematocrit in humans. Crit Care Med1991;19(8):1025–1029.
182.
VaughnS, PuriVK. Cardiac output changes and continuous mixed.
183.
ScuderiPE, BowtonDL, MeredithJW, HarrisLC, EvansJB, AndersonRL. A comparison of three pulmonary artery oximetry catheters in intensive care unit patients. Chest1992;102(3):896–905.
184.
ScuderiPE, MacGregorDA, BowtonDL, JamesRL. A laboratory comparison of three pulmonary artery oximetry catheters. Anesthesiology1994;81(1):245–253.
185.
WongDH, WeirP, MahutteCK, OnishiR, DavesS, ForanW, et al. Experimental and predicted dual oximetry variability. J Clin Monit1993;9(4):268–274.
186.
GattinoniL, BrazziL, PelosiP, LatiniR, TognoniG, PesentiA, FumagalliR, SvO₂ Collaborative Group. A trial of goal-oriented hemodynamic therapy in critically ill patients. N Engl J Med1995;333(16):1025–1032.
187.
SilvermanHJ. Gastric tonometry: an index of splanchnic tissue oxygenation? (editorial)Crit Care Med1991;19(10):1223–1224.
188.
GysT, HubensA, NeelsH, LauwersLF, PeetersR.Prognostic value of gastric intramural pH in surgical intensive care patients. Crit Care Med1988;16(12):1222–1224.
189.
LandowL, PhillipsDA, HeardSO, PrevostD, VandersalmTJ, FinkMP. Gastric tonometry and venous oximetry in cardiac surgery patients. Crit Care Med1991;19(10):1226–1233.
190.
HartmannM, MontgomeryA, JönssonK, HaglundU.Tissue oxygenation in hemorrhagic shock measured as transcutaneous oxygen tension, subcutaneous oxygen tension, and gastrointestinal intramucosal pH in pigs. Crit Care Med1991;19(2):205–210.
191.
SilvermanHJ, TumaP.Gastric tonometry in patients with sepsis. Effects of dobutamine infusions and packed red blood cell transfusions. Crit Care Med1992;102(1):184–188.
192.
GutierrezG, BismarH, DantzkerDR, SilvaN.Comparison of gastric intramucosal pH with measures of oxygen transport and consumption in critically ill patients. Crit Care Med1992;20(4):451–457.
193.
GutierrezG, PalizasF, DoglioG, WainszteinN, GallesioA, PacinJ, et al. Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet1992;339(8787):195–199.
MohsenifarZ, HayA, HayJ, LewisMI, KoernerSK. Gastric intramural pH as a predictor of success or failure in weaning patients from mechanical ventilation. Ann Intern Med1993;119(8):794–798.
196.
MarikPE. Gastric intramucosal pH. A better predictor of multiorgan dysfunction syndrome and death than oxygen-derived variables in patients with sepsis. Chest1993;104(1):225–229.
197.
KnichwitzG, Van AkenH, BrusselT.Gastrointestinal monitoring using measurement of intramucosal PCO2. Anesth Analg1998;87(1):134–142.
198.
KnichwitzG, KuhmannM, BrodnerG, MertesN, GoetersC, BrusselT.Gastric tonometry: precision and reliability are improved by a phosphate buffered solution. Crit Care Med1996;24(3):512–516.
199.
TakalaJ, ParviainenI, SiloajhoM, RuokonenE, HamalainenE.Saline PCO2 is an important source of error in the assessment of gastric intramucosal pH. Crit Care Med1994;22(11):1877–1879.
200.
RiddingtonD, VenkateshB, Clutton-BrockT, BrionJ.Measuring carbon dioxide tension in saline and alternative solutions: quantification of bias and precision in two blood gas analyzers. Crit Care Med1994;22(1):96–100.
201.
CreteurJ, De BackerD, VincentJL. Monitoring gastric intramucosal carbon dioxide pressure using gas tonometry: in vitro and in vivo validation studies. Anesthesiology1997;87(3):504–510.
202.
GuzmanJA, KruseJA. Development and validation of a technique for continuous monitoring of gastric intramucosal pH. Am J Respir Crit Care Med1996;153(2):694–700.
203.
KnichwitzG, RotkerJ, BrusselT, KuhmannM, MertesN, MollhoffT.A new method for continuous intramucosal PCO2 measurement in the gastrointestinal tract. Anesth Analg1996;83(1):6–11.
204.
BrownSD, GutierrezG.Does gastric tonometry work? Yes. Crit Care Clin1996;12(3):569–585.
205.
BenjaminE, OropelloJM. Does gastric tonometry work? No. Crit Care Clin1996;12(3):587–601.
206.
KahnDM, CookTE, CarlisleCC, NelsonDL, KramerNR, MillmanRP. Identification and modification of environmental noise in an ICU setting. Chest1998;114(2):535–540.
PearsonKS, GomezMN, MoyersJR, CarterJG, TinkerJH. A cost/benefit analysis of randomized invasive monitoring for patients undergoing cardiac surgery. Anesth Analg1989;69(3):336–341.
209.
JastremskiMS, ChelluriL, BeneyKM, BaillyRT. Analysis of the effects of continuous on-line monitoring of mixed venous oxygen saturation on patient outcome and cost effectiveness. Crit Care Med1989;17(2):148–153.