The experimental studies relating to the effect of various types of radiation on learning, activity and manipulation, conditioning, and discrimination are discussed. The difficulty of inferring an effect in man, and the confounding due to uncontrolled variables are highlighted. Recommendations for further experimental studies are presented, and a comprehensive bibliography of selected material on radiation is included.
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References
1.
ArnoldW. J., Maze learning and retention after x-radiation of the head. J. Comp. Physiol. Psych., 45, 358, 1952.
2.
BlairW. C.ArnoldW. J., The effects of cranial x-radiation on retention of maze learning in rats. J. Comp. Physiol. Psych., 49, 525, 1956.
3.
BlairW. C., The effects of cranial x-radiation on maze acquisition in rats. J. Comp. Physiol. Psych., 51, 175, 1958.
4.
DavisR. T.McDowellA. A.DeterC. W.SteeleJ. P., Performance of rhesus monkeys on selected laboratory tasks presented before and after a large single dose of whole-body x-radiation. J. Comp. Physiol. Psych., 49, 20, 1956.
5.
FieldsP. E., The effect of whole-body x-radiation upon activity drum, straightaway and maze performance of white rats. J. Comp. Physiol. Psych., 50, 386, 1957.
6.
FredenS. C.WhiteR. S., Inner Van Allen radiation belt identified Missiles and Rockets. American Aviation Publications, Inc., June 15, 1959.
7.
FurchtgottE., Effects of total body x-irradiation in learning; an exploratory study. J. Comp. Physiol. Psych., 44, 197, 1951.
8.
FurchtgottE., The effects of x-irradiation on brightness discrimination. J. Psychol., 34, 37, 1952.
9.
GarciaJ.KimeldorfD. J.KoelingR. A., Conditioned aversion to saccharin resulting from exposure to gamma radiation. Science, 122, 157, 1955.
10.
HarlowH. F.SchrierA. M.SimonsD. G., Exposure of primates of cosmic radiation above 90,000 feet. J. Comp. Physiol. Psych., 49, 195, 1956.
11.
KaplanS. J.GentryG., Some effects of sublethal dose of x-radiation upon transfer of training in monkeys. USAF SAM Project No. 21–3501–0003 Rep. No. 4, December 1953.
12.
KaplanS. T.TaitC. D.WallP. D.PayneR. E., Behavioral changes following radiation: 1. Study of retention of a partially learned maze habit. Unnumbered Project, Rep. No. 1, USAF School of Aviation Medicine, Randolph Field, Texas, March, 1951. 2. Maternal behavior and maze performance. USAF, School of Aviation Medicine, Special Report, July 1952.
13.
LearyR. C.RuchT. C., Activity, manipulation drive, and strength in monkeys subjected to low level radiation. J. Comp. Physiol. Psych., 48, 336, 1955.
14.
LundinJ.ClemedsonC.-J.NelsonA., Early effects of whole body irradiation on cholin-esterase activity in guineapigs' blood with special regard to radiation sickness. Acta. Radiol., 48, 52, 1957.
15.
LymanR. S.KupalovP. S.ScholzW., Effects of roentgen rays on the central nervous system. Arch. Neurol. Psychat., Chicago, 29, 56, 1933.
16.
McLeanF. G.RustJ. H.BudyA. M., Extension to man of experimental whole-body radiation studies. Military Surgeon, 112, 174, 1953.
17.
MelchingW. H.KaplanS. J., Some effects of a lethal dose of x-radiation upon retention: Studies of shock avoidance motivation. USAF SAM Project No. 21–3501–0003, Rep. No. 9, August 1954.
18.
NemenowM. I., The effect of roentgen ray exposure of the cerebral hemispheres. Radiology, 23, 86, 1933.
19.
RiopelleA. J.GrodskyM. A.AdesH. W., Learned performance of monkeys after single and repeated x-radiations. J. Comp. Physiol. Psych., 49, 521, 1956.
20.
RogersC. M.KaplanS. J.GentryG.AuxierJ. A., Some effects of cumulative doses of x-radiation upon learning and retention in the rhesus monkey. USAF SAM Rep. No. 21–3501–0003, Rep. No. 11, November 1954.
21.
WarrenJ. M.KaplanS. J., A study of discrimination learning in monkeys with implications for the investigation of the psychobiological effects of ionizing radiation. USAF SAM Project No. 21–3501–0003 report No. 6, July 1954.
22.
WarrenJ. M.KaplanS. J.GreenwoodD. D., The solution of discrimination reversal problems by normal and irradiated monkeys. USAF, School of Aviation Medicine, Proj. Rep. 1955, Proj. No. 21–3501–0003, Rep. No. 16.
23.
National Bureau of Standards: Recommendation of the international commission of radiological protection and of the international commission on radiological units, 1950. National Bureau of Standards Handbook 47.
24.
BachoferC. S., Enhancement of activity of nerves by x-rays. Science, 125, 1140, 1957.
25.
BirgeA. C., Laboratory studies for evaluating the biological effects of primary cosmic radiation. J. Aviat. Med., 25, 326, 1954.
26.
CampbellB., A biological study of the effects of the heavy particle component of cosmic rays. J. Aviat. Med., 25, 361, 1954.
27.
CasterW. O.RedgateE. S.ArmstrongW. D., Changes in the central nervous system after 700r total body x-radiation. Radiation Research, 8, 92, 1958.
ElderdE.TrowbridgeWm. V., Neurological and EEG findings in the monkey after total body x-irradiation. EEG Clin. Neurophysiol., 5, 259, 1953.
30.
FurchtgottE., Behavioral effects of total body x-irradiation in the rat: An exploratory study. Ph.D. Thesis, University of California (unpublished) 1950.
GerstnerH. B., Military and civil defense aspects of the acute radiation syndrome in man. School of Aviation Medicine, Randolph AFB, Texas, AF–SAM–58–6. July 19, 1957.
33.
GolubtsovaA. V.MoiseenkoE. V.SafronovaM. I., Changes in cerebellum tissue metabolism with irradiation by x-rays. Bull. Exp. Biol. Med. (USSR)41, 763, 1956.
34.
HagenJ. P., The Vanguard project. J. Aviat. Med., 28, 503, 1957.
35.
HowarthJ. L., Dosimetry of ionizing radiations. In, “Aviation Medicine, Selected Reviews,”WhiteC. S.LovelaceW. R.HirschF. G. (Eds.), Pergamon Press, London, 1958.
36.
KaplanS. J.ThomasG. E., The research program for the University of Texas. USAF SAM Primate Laboratory Project No. 21–3501–0003, Rep. No. 1, October 1953.
37.
KaplanS. J.GentryG., Some effects of a lethal dose of x-radiation upon memory. A case history study. USAF SAM Project No. 21–3501–0003, Rep. No. 2, June 1954.
38.
KaplanS. J.GentryG., A general test apparatus for infrahuman primates. USAF SAM Project No. 21–3501–0003, Rep. No. 3, September 1953.
39.
KaplanS. J.GentryG.MelchingW. H.DelitM., Some effects of a lethal dose of x-radiation upon retention in monkeys. USAF SAM Project No. 21–3501–0003, Rep. No. 8, August 1954.
40.
KonecciE. B., Tolerance to simulated altitude after whole body x-irradiation in guinea pigs. J. Aviat., Med., 26, 130, 1955.
41.
KonecciE. B.DanfordM. B., Biological and medical aspects of ionizing radiation: Spinal reflex activity and local x-radiation. USAF School of Aviation Medicine, Rep. No. 56–90, 1956.
42.
KonecciE. B., Calculations of the radiobiological risk factors involved in future nuclear powered space vehicles. 30th Annual Aero Medical Convention, April 1959.
43.
KrechD.RosenzweigM. R.BennetE. L., Dimensions of discrimination and level of cholinesterase activity in the cerebral cortex of the rat. J. Comp. Physiol. Psych., 49, 261, 1956.
44.
LooneyW. B., Effects of radiation in man. Science, 127, No. 3299, 1958.
45.
MalisL. I.LoevingerR.KrugerL.RoseJ. E., Production of laminar lesions in the cerebral cortex by heavy ionizing particles. Science, 126, 302, 1957.
46.
McDowellA. A.DavisR. T.SteelJ. P., Application of systematic direct observational methods to analysis of the radiation syndrome in monkeys. Percept. Mot. Skills, 6, 117, 1956.
47.
NearyG. J.MunsonR. J.MoleR. H., “Chronic Radiation Hazards. An Experimental Study with Fast Neutrons.”Pergamon Press, New York (QH652 N27C) 1957.
48.
ReidJ. B.KaplanS. J.MelchingW. H., A method for analysis of gross behavior. USAF SAM Project No. 21–3501–0003, Rep. No. 10, June 1955.
49.
RosenfieldG., The function and capacity of the adrenal cortex immediately before radiation sickness. J. Lab. Clin. Med., 51, 198, 1958.
50.
SchaeferH. J., Theory of the protection of man in the region of the primary cosmic radiation. J. Aviat. Med., 25, 338, 1954.
51.
SchaeferH. J., Definition of a permissible dose for primary cosmic radiation. J. Aviat. Med., 25, 392, 1954.
52.
SchaeferH. J., Optimum altitudes for biological experimentation with the primary cosmic radiation. J. Aviat. Med., 27, 512, 1957.
53.
SchaeferH. J., New knowledge of the extra-atmospheric radiation field. J. Aviat. Med., 29, 492, 1959.
54.
SchaeferH. J., Radiation doses in flight through the radiation belt. 30th Annual Aero Medical Convention, April 1959.
55.
ShepherdL. R., The possibility of cosmic ray hazards in high altitude and space flight. J. Brit. Interplan. Soc., 12, 197, 1953.
56.
SimonsD. G.ParksD. P., Improved techniques for exposing animals to primary cosmic ray particles. J. Aviat. Med., 27, 317, 1957.
57.
StoneR. S., The concept of maximum permissible exposure. Radiology, 58, 639, 1952.
58.
StorerJ. B.FurchnerJ. E.KrebsA. T., Specific ionization and relative biological effectiveness of ionizing radiations in mammalian systems. J. Aviat. Med., 25, 368, 1954.
59.
TobiasC. A., Radiation hazards in high altitude aviation. J. Aviat. Med., 23, 345, 1952.
60.
Van AllenJ. A.LudwigG. H.RayE. C.Mc AlwainC. E., Observation of high intensity radiation by satellites. 1958 Alpha and Gamma (Explorer I and III). Jet Propulsion, 28, 588, 1958.
61.
WhiteC. S.BensonO. O. (Eds.), “Physics and Medicine of the Upper Atmosphere, a Study of the Aeropause.”University of New Mexico Press, Albuquerque, 1952.
62.
BurnightT. R., Uultraviolet radiation and x-rays of solar origin, pp. 226–238.
63.
Van AllenJ. A., The nature and intensity of the cosmic radiation, pp. 239–266.
64.
KrebsA. T., The biologic effects of laboratory radiation, pp. 267–289.
65.
SchaeferH. J., The biologic effects of cosmic radiation, pp. 316–330.
66.
KrebsA. T., Methods of assuring the biologic effects of ionizing radiation and methods of measuring it, pp. 471–478.
67.
EvansT. C., A discussion of the potential effects on man of ionizing radiation present in the upper atmosphere, pp. 533–539.
68.
TalbotJ. M., The biological effects of power plan radiation, pp. 540–543.
69.
BuettnerK., Biological effects of radiation of possible extraterrestrial origin, pp. 544–547.