Probiotics for Atopic Dermatitis Prevention in Infants: Emerging Promise Amid Inconsistent Evidence and Guideline Divergence – A Perspective for Hospital Pharmacists
Restricted accessLetterFirst published online April, 2026
Probiotics for Atopic Dermatitis Prevention in Infants: Emerging Promise Amid Inconsistent Evidence and Guideline Divergence – A Perspective for Hospital Pharmacists
DruckerAMWangARLiWQSevetsonEBlockJKQureshiAA.The burden of atopic dermatitis: summary of a report for the National Eczema Association. J Invest Dermatol. 2017;137(1):26-30.
WangLXuL.The impact of prebiotics, probiotics and synbiotics on the prevention and treatment of atopic dermatitis in children: an umbrella meta-analysis. Front Pediatr. 2025;13:1498965.
4.
Tan-LimCSCEsteban-IpacNARRectoMSTCastorMARMacalalad-JasminRARMendozaOM. Comparative effectiveness of probiotic strains on the prevention of pediatric atopic dermatitis: a systematic review and network meta-analysis. Pediatr Allergy Immunol. 2021;32(7):1448-1462.
5.
CabanaMDMcKeanMCaugheyAB, et al. Early probiotic supplementation for eczema and asthma prevention: a randomized controlled trial. Pediatrics. 2017;140(3):e20163000.
6.
Cuello-GarciaCABrożekJLFiocchiAZhangYMorganoGPSchünemannHJ.Probiotics for the prevention of allergy: a systematic review and meta-analysis of randomized controlled trials. J Allergy Clin Immunol. 2015;136(4):952-961.
7.
FiocchiAPawankarRCuello-GarciaC, et al. World Allergy Organization – McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): probiotics. World Allergy Organ J. 2015;8(1):Article 4.
8.
BraeggerCChmielewskaADecsiT, et al. Supplementation of infant formula with probiotics and/or prebiotics: a systematic review and comment by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2011;52(2):238-250.
9.
NICE (National Institute for Health and Care Excellence). Atopic Eczema in Under 12s: Diagnosis and Management (CG57). NICE; 2007.
10.
JoshiPASmithJNotenboomMOsborneNJNettingMJ.ASCIA guidelines for infant feeding and allergy prevention. Med J Aust. 2019;210(2):89-93.
U.S. Food and Drug Administration. Warning regarding use of probiotics in preterm infants (One-page summary, September 29, 2023). 2023c. Accessed August 29, 2025. Available at: https://www.fda.gov/media/172606/download
SchulzKFAltmanDGMoherD.CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Br Med J. 2010;340:c332.
16.
IoannidisJPAEvansSJWGøtzschePC, et al. Better reporting of harms in randomized trials: an extension of the CONSORT statement. Ann Intern Med. 2004;141(10):781-788.
17.
SchmittJSpulsPIThomasKS, et al. The Harmonising Outcome Measures for Eczema (HOME) statement to standardise outcomes in eczema clinical trials. J Invest Dermatol. 2014;134(12):2955-2960.
18.
HillCGuarnerFReidG, et al. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506-514.
19.
SwansonKSGibsonGRHutkinsR, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat Rev Gastroenterol Hepatol. 2020;17(11):687-701.
20.
HusereauDDrummondMAugustovskiF, et al. Consolidated Health Economic Evaluation Reporting Standards (CHEERS) 2022 explanation and elaboration: a report of the ISPOR CHEERS II Good Practices Task Force. Value Health. 2022;25(1):10-31.
