Agnostic Drugs: A New Paradigm in Pharmacological Therapy

Abstract

Get full access to this article

View all access options for this article.

References

Drilon

Laetsch

Kummar

, et al. Efficacy of larotrectinib in TRK fusion-positive cancers in adults and children. N Engl J Med. 2018;378(8):731-739.

Doebele

Drilon

Paz-Ares

, et al. Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials. Lancet Oncol. 2020;21(2):271-282.

US Food and Drug Administration. FDA approves larotrectinib for solid tumors with NTRK gene fusions. November 26, 2018. Accessed March 2025. https://www.fda.gov/drugs/fda-approves-larotrectinib-solid-tumors-ntrk-gene-fusions-0

US Food and Drug Administration. FDA approves entrectinib for NTRK solid tumors and ROS-1 NSCLC. August 15, 2019. Accessed March 2025. https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-entrectinib-ntrk-solid-tumors-and-ros-1-nsclc

Zhao

Jiang

Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy. J Hematol Oncol. 2019;12(1):54. doi:10.1186/s13045-019-0738-1

Tannock

Hickman

JA.

Limits to personalized cancer medicine. N Engl J Med. 2016;375(13):1289-1294.

Collins

Varmus

A new initiative on precision medicine. N Engl J Med. 2015;372(9):793-795.

Meric-Bernstam

Johnson

Holla

, et al. A decision support framework for genomically informed investigational cancer therapy. J Natl Cancer Inst. 2015;107(7):djv098.

Moslehi

Deininger

Tyrosine kinase inhibitor-associated cardiovascular toxicity in chronic myeloid leukemia. J Clin Oncol. 2015;33(35):4210-4218.

10.

Normanno

De Luca

Abate

, et al. Current practice of genomic profiling of patients with advanced solid tumours in Italy: the Italian Register of Actionable Mutations (RATIONAL) study. Eur J Cancer. 2023;187:174-184. doi:10.1016/j.ejca.2023.03.027

11.

Cummings

Lee

Ritter

Zhong

Alzheimer’s disease drug development pipeline: 2021. Alzheimers Dement (NY). 2021;7(1):e12179.

12.

Topol

EJ.

High-performance medicine: the convergence of human and artificial intelligence. Nat Med. 2019;25(1):44-56.

13.

Zhou

Yang

Wang

, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-273.