Background: The peculiarities of medication errors (MEs) among the pediatric population in the Middle East have not been adequately explored. In this study, we describe the MEs reported at the largest tertiary hospital in Saudi Arabia. Methods: This study is a retrospective analysis of MEs reported by health care professionals at a large tertiary hospital in Saudi Arabia between 2015 and 2016. Results: There were a total of 9123 MEs involving 84 different medications. In total, 109 382 drugs were ordered. Thus, 8.3 MEs per 100 prescriptions were reported during the study period. Thirty-nine errors (0.4%) reached the patient, but did not cause any harm. Transcribing errors accounted for more than half of the MEs (n = 4856, 53.2%). Physicians were the least likely to report an ME (n = 159, 1.7%), whereas pharmacists reported more MEs than any other health care professional (n = 4924, 54%). The most common drug causes of MEs were paracetamol, salbutamol, and amoxicillin, which accounted for 21.0%, 16.6%, and 12.4% of MEs, respectively, over the study period. Conclusions: Medication errors are common in pediatric care, especially for drugs such as paracetamol and amoxicillin that are frequently prescribed. Transcription error was common in this study and is more likely to be reported by pharmacists.
AlsulamiZConroySChoonaraI. Medication errors in the Middle East Countries: a systematic review of the literature. Eur J Clin Pharmacol. 2013;69:995-1008.
3.
AljadheyHMahmoudMAAhmedY, et al. Incidence of adverse drug events in public and private hospitals in Riyadh, Saudi Arabia: the (ADESA) prospective cohort study. BMJ Open. 2016;6:e010831.
4.
BatesDW. Medication errors. How common are they and what can be done to prevent them?Drug Saf. 1996;15(5):303-310.
5.
LisbyMNielsenLPBrockBMainzJ. How are medication errors defined? a systematic literature review of definitions and characteristics. Int J Qual Health Care. 2010;22:507-518.
6.
LewisPJDornanTTaylorDTullyMPWassVAshcroftDM. Prevalence, incidence and nature of prescribing errors in hospital inpatients: a systematic review. Drug Saf. 2009;32:379-389.
7.
ClassenDCPestotnikSLEvansRSLloydJFBurkeJP. Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality. JAMA. 1997;277:301-306.
8.
PhillipsJBeamSBrinkerA, et al. Retrospective analysis of mortalities associated with medication errors. Am J Health Syst Pharm. 2001;58:1835-1841.
WongICWongLYCranswickNE. Minimising medication errors in children. Arch Dis Child. 2009;94:161-164.
11.
BuckML. Preventing medication errors in children. Paediatr Pharmacotherapy. 1999;5:1-8.
12.
ConroyS. Association between licence status and medication errors. Arch Dis Child. 2011;96:305-306.
13.
GrahamAS. Prescribing errors. J Health Syst Pharm. 2008;65:5-15.
14.
MillerMRRobinsonKALubomskiLHRinkeMLPronovostPJ. Medication errors in paediatric care: a systematic review of epidemiology and an evaluation of evidence supporting reduction strategy recommendations. Qual Saf Health Care. 2007;16:116-126.
15.
National Coordinating Council for Medication Error Reporting and Prevention. http://www.nccmerp.org/. Accessed May 2, 2017.
16.
AlomarySIAljarallahMFAlmodaimeghHAlluhidanLAMaswadiE. Prevalence and types of medication errors at King Abdullah Specialized Children Hospital, Riyadh, Saudi Arabia. Int J Adv Res. 2016;4:1670-1678.
17.
Al-JeraisyMIAlanaziMQAbolfotouhMA. Medication prescribing errors in a pediatric inpatient tertiary care setting in Saudi Arabia. BMC Res Notes. 2011;4:294.
18.
NeyazYKhojaTQureshiNAMagzoubMAHaycoxAWalleyT. Medication prescribing pattern in primary care in Riyadh City, Saudi Arabia. East Mediterr Health J. 2011;17:149-155.
19.
GuptaNSafhiMMSumailyJMYAgarwalM. Drug prescribing patterns in children registered in the department of pediatrics of Jizan General Hospital of Jazan, KSA. Int J Pharm Pharm Sci. 2013;5:397-399.
20.
TaxisKDeanBBarberN. Hospital drug distribution systems in the UK and Germany—a study of medication errors. Pharm World Sci. 1999;21:25-31.
21.
DaveyALBrittanANaylorRJ. Decreasing paediatric prescribing errors in a district general hospital. Qual Saf Health Care. 2008;17:146-149.
22.
RossLMWallaceJPatonJY. Medication errors in a paediatric teaching hospital in the UK: five years operational experience. Arch Dis Child. 2000;83:492-497.
23.
ZelekeAChanieTWoldieM. Medication prescribing errors and associated factors at the pediatric wards of Dessie Referral Hospital, Northeast Ethiopia. Int Arch Med. 2014;7:18.
24.
AliSAboheimedNIAl-ZaagiIAAl-DossariDS. Analysis of medication errors at a large tertiary care hospital in Saudi Arabia: a retrospective analysis. Int J Clin Pharm. 2017;39:1004-1007.
25.
KnudsenPHerborgHMortensenARKnudsenMHellebekA. Preventing medication errors in community pharmacy: root-cause analysis of transcription errors. Qual Saf Health Care. 2007;16:285-290.
26.
AmmenwerthESchnell-InderstPMachanCSiebertU. The effect of electronic prescribing on medication errors and adverse drug events: a systematic review. J Am Med Inform Assoc. 2008;15:585-600.
27.
BrownJNBarnesCLBeasleyBCisnerosRPoundMHerringC. Effect of pharmacists on medication errors in an emergency department. Am J Health Syst Pharm. 2008;65:330-333.
28.
JaniYHGhalebMAMarksSDCopeJBarberNWongIC. Electronic prescribing reduced prescribing errors in a pediatric renal outpatient clinic. J Pediatr. 2008;152:214-218.
29.
StarmerAJSectishTCSimonDW, et al. Rates of medical errors and preventable adverse events among hospitalized children following implementation of a resident handoff bundle. JAMA. 2013;310:2262-2270.
30.
PhamJCStoryJLHicksRW, et al. National study on the frequency, types, causes, and consequences of voluntarily reported emergency department medication errors. J Emerg Med. 2011;40:485-492.
