Abstract
This chart is an update to the 2012 article published in Hospital Pharmacy on injectable drugs to be used with a filter. To update the chart, drugs approved from December 2011 to April 2019 were reviewed to determine if they require filtration and drugs included in the 2012 table were reviewed for accuracy. Readers are urged to review national standards of practice for information about clinical situations that warrant the use of a filter for medication preparation or administration, independent of the drug being given, and the reader should consult the Food and Drug Administration (FDA)-approved prescribing information for the most up-to-date information.
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References
1.Drugs to be used with a filter for preparation and/or administration . Hosp Pharm . 2012 ;47 (5 ):351 -359 .
2.
Gahart
BL
Nazareno
AR
Ortega
MQ.
Intravenous Medications: A Handbook for Nurses and Health Professionals . 35th ed. St Louis, MO : Elsevier ; 2019 . https://www-clinicalkey-com.proxy.cc.uic.edu/#!/browse/book/3-s2.0-C20170029579. Accessed February 15, 2019 .
3.
McEvoy
GK
Snow
EK
Miller
J
, eds. Handbook on Injectable Drugs . 19th ed. Bethesda, MD : American Society of Health-System Pharmacists ; 2018 . https://www-medicinescomplete-com.proxy.cc.uic.edu/#/browse/hid. Accessed February 15, 2019 .
4.
Clinical Pharmacology Powered by ClinicalKey
. Tampa, FL : Elsevier ; 2019 . http://www.clinicalkey.com.proxy.cc.uic.edu. Accessed February 15, 2019 .
5.
Gorski
L
Hadaway
L
Hagle
ME
McGoldrick
M
Orr
M
Doellman
D.
Infusion therapy standards of practice . J Infus Nurs . 2016 ;39 (suppl 1 ):S1 -S159 .
6.Orencia [package insert] . Princeton, NJ : Bristol-Myers Squibb Company ; 2017 .
7.Reopro [package insert] . Horsham, PA : Janssen Biotech Inc ; 2018 .
8.Kadcyla [package insert] . South San Francisco, CA : Genentech Inc ; 2018 .
9.Eylea [package insert] . Tarrytown, NY : Regeneron Pharmaceuticals, Inc ; 2018 .
10.Fabrazyme [package insert] . Cambridge, MA : Genzyme Corporation ; 2010 .
11.Buminate 25% [package insert] . Westlake Village, CA : Baxalta US Inc ; 2015 .
12.Albuked [package insert] . Fort Lee, NJ : Kedrion Biopharma, Inc ; 2014 .
13.Albuminar [package insert] . Kankakee, IL : CSL Behring LLC ; 2013 .
14.AlbuRx [package insert] . Kankakee, IL : CSL Behring LLC ; 2014 .
15.Albutein [package insert] . Los Angeles, CA : Grifols Biologicals Inc ; 2015 .
16.Flexbumin [package insert] . Lexington, MA : Baxalta US Inc ; 2017 .
17.Kedbumin [package insert] . Fort Lee, NJ : Kedrion Biopharma, Inc ; 2014 .
18.Plasbumin [package insert] . Research Triangle Park, NC : Grifols Therapeutics Inc ; 2017 .
19.Lumizyme [package insert] . Cambridge, MA : Genzyme Corporation ; 2014 .
20.Aralast [package insert] . Westlake Village, CA : Baxalta US Inc ; 2015 .
21.Glassia [package insert] . Lexington, MA : Baxalta US Inc ; 2017 .
22.Prolastin [package insert] . Research Triangle Park, NC : Grifols Therapeutics LLC ; 2018 .
23.Zemaira [package insert] . Kankakee, IL : CSL Behring LLC ; 2018 .
24.Kabiven [package insert] . Lake Zurich, IL : Fresenius Kabi USA, LLC ; 2016 .
25.Perikabiven [package insert] . Lake Zurich, IL : Fresenius Kabi USA, LLC ; 2016 .
26.Nexterone [package insert] . Deerfield, IL : Baxter Healthcare Corporation ; 2016 .
27.Amiodarone [package insert] . Rockford, IL : Mylan Institutional LLC ; 2017 .
28.Abelcet [package insert] . Indianapolis, IN : Exelead Inc ; 2017 .
29.Ambisome [package insert] . San Dimas, CA : Gilead Sciences Inc ; 2018 .
30.Andexxa [package insert] . South San Francisco, CA : Portola Pharmaceuticals Inc ; 2018 .
31.Hemofil M [package insert] . Lexington, MA : Baxalta US Inc ; 2018 .
32.Monoclate-P [package insert] . Kankakee, IL : CSL Behring LLC ; 2014 .
33.Advate [package insert] . Lexington, MA : Baxalta US Inc ; 2018 .
34.Adynovate [package insert] . Westlake Village, CA : Baxalta US Inc ; 2018 .
35.Afstyla [package insert] . Kankakee, IL : CSL Behring LLC ; 2017 .
36.Eloctate [package insert] . Cambridge, MA : Biogen Inc ; 2017 .
37.Esperoct [package insert] . Plainsboro, NJ : Novo Nordisk Inc ; 2019 .
38.Jivi [package insert] . Whippany, NJ : Bayer HealthCare LLC ; 2018 .
39.Koate [package insert] . Research Triangle Park, NC : Grifols Therapeutics ; 2016 .
40.Kogenate FS [package insert] . Whippany, NJ : Bayer HealthCare LLC ; 2016 .
41.Kovaltry [package insert] . Whippany, NJ : Bayer HealthCare LLC ; 2016 .
42.Novoeight [package insert] . Plainsboro, NJ : Novo Nordisk Inc ; 2018 .
43.Nuwiq [package insert] . Hoboken, NJ : Octapharma USA Inc ; 2017 .
44.Obizur [package insert] . Westlake Village, CA : Baxalta US Inc ; 2015 .
45.Recombinate [package insert] . Lexington, MA : Baxalta US Inc ; 2018 .
46.Xyntha [package insert] . Philadelphia, PA : Wyeth Pharmaceuticals Inc ; 2014 .
47.Alphanate [package insert] . Los Angeles, CA : Grifols Biologicals Inc ; 2017 .
48.Humate-P [package insert] . Kankakee, IL : CSL Behring LLC ; 2017 .
49.Wilate [package insert] . Hoboken, NJ : Octapharma USA, Inc ; 2016 .
50.Atryn [package insert] . Framingham, MA : rEVO Biologics Inc ; 2013 .
51.Thrombate III [package insert] . Research Triangle Park, NC : Grifols Therapeutics LLC ; 2018 .
52.Thymoglobulin [package insert] . Cambridge, MA : Genzyme Corporation ; 2018 .
53.Bavencio [package insert] . Rockland, MA : EMD Serono Inc ; 2018 .
54.Nulojix [package insert] . Princeton, NJ : Bristol-Myers Squibb Company ; 2018 .
55.Beleodaq [package insert] . Irvine, CA : Spectrum Pharmaceuticals, Inc ; 2017 .
56.Zinplava [package insert] . Whitehouse Station, NJ : Merck & Co. Inc ; 2016 .
57.Blincyto [package insert] . Thousand Oaks, CA : Amgen Inc ; 2018 .
58.BAT [package insert] . Winnipeg, Manitoba, Canada : Cangene Corporation ; 2017 .
59.BabyBIG [package insert] . Westlake Village, CA : Baxter Healthcare Corporation ; 2015 .
60.Berinert [package insert] . Kankakee, IL : CSL Behring LLC ; 2017 .
61.Haegarda [package insert] . Kankakee, IL : CSL Behring LLC ; 2017 .
62.Cinryze [package insert] . Lexington, MA : Shire ViroPharma Incorporated ; 2018 .
63.Jevtana [package insert] . Bridgewater, NJ : Sanofi-Aventis US LLC ; 2018 .
64.Libtayo [package insert] . Tarrytown, NY : Regeneron Pharmaceuticals, Inc ; 2018 .
65.Brineura [package insert] . Novato, CA : BioMarin Pharmaceutical Inc ; 2018 .
66.Erbitux [package insert] . Branchburg, NJ : ImClone LLC ; 2018 .
67.Cladribine [package insert] . Rockford, IL : Mylan Institutional LLC ; 2018 .
68.Clolar [package insert] . Bridgewater, NJ : Sanofi-Aventis US LLC ; 2017 .
69.Cytogam [package insert] . Kankakee, IL : CSL Behring LLC ; 2018 .
70.Darzalex [package insert] . Horsham, PA : Janssen Biotech Inc ; 2018 .
71.Defitelio [package insert] . Palo Alto, CA : Jazz Pharmaceuticals Inc ; 2016 .
72.Imfinzi [package insert] . Wilmington, DE : AstraZeneca Pharmaceuticals LP ; 2018 .
73.Vimizim [package insert] . Novato, CA : BioMarin Pharmaceutical Inc ; 2018 .
74.Empliciti [package insert] . Princeton, NJ : Bristol-Myers Squibb Company ; 2017 .
75.Gamifant [package insert] . Waltham, MA : Sobi Inc ; 2018 .
76.Flolan [package insert] . Research Triangle Park, NC : GlaxoSmithKline ; 2018 .
77.Veletri [package insert] . South San Francisco, CA : Actelion Pharmaceuticals US Inc ; 2018 .
78.Netspot [package insert] . New York, NY : Advanced Accelerator Applications USA Inc ; 2018 .
79.Naglazyme [package insert] . Novato, CA : BioMarin Pharmaceutical Inc ; 2018 .
80.Mylotarg [package insert] . Philadelphia, PA : Wyeth Pharmaceuticals Inc ; 2018 .
81.Simponi aria [package insert] . Horsham, PA : Janssen Biotech, Inc ; 2018 .
82.Panhematin [package insert] . Raleigh, NC : Xellia Pharmaceuticals USA, LLC ; 2017 .
83.Octaplas [package insert] . Hoboken, NJ : Octapharma USA Inc ; 2015 .
84.Zevalin [package insert] . Irvine, CA : Spectrum Pharmaceuticals Inc ; 2013 .
85.Elaprase [package insert] . Lexington, MA : Shire Human Genetic Therapies, Inc ; 2018 .
86.Gammagard S/D [package insert] . Lexington, MA : Baxalta US Inc ; 2017 .
87.Bivigam [package insert] . Boca Raton, FL : Biotest Pharmaceuticals Corporation ; 2014 .
88.Carimune NF [package insert] . Kankakee, IL : CSL Behring LLC ; 2018 .
89.Flebogamma DIF [package insert] . Barcelona, Spain : Grifols USA LLC ; 2017 .
90.Gammagard Liquid [package insert] . Westlake Village, CA : Baxalta US Inc ; 2016 .
91.Gammaked [package insert] . Research Triangle Park, NC : Grifols Therapeutics Inc ; 2017 .
92.Gammaplex 10% [package insert] . Durham, NC : BPL Inc ; 2018 .
93.Gammaplex 5% [package insert] . Durham, NC : BPL Inc ; 2018 .
94.Gamunex [package insert] . Research Triangle Park, NC : Grifols Therapeutics Inc ; 2017 .
95.Octagam [package insert] . Hoboken, NJ : Octapharma USA Inc ; 2018 .
96.Panzyga [package insert] . Hoboken, NJ : Octapharma USA Inc ; 2018 .
97.Privigen [package insert] . Kankakee, IL : CSL Behring LLC ; 2017 .
98.Remicade [package insert] . Horsham, PA : Janssen Biotech, Inc ; 2018 .
99.Renflexis [package insert] . Whitehouse Station, NJ : Merck & Co. Inc ; 2017 .
100.Inflectra [package insert] . New York, NY : Pfizer Inc ; 2018 .
101.Azedra [package insert] . New York, NY : Progenics Pharmaceuticals, Inc ; 2018 .
102.Yervoy [package insert] . Princeton, NJ : Bristol-Myers Squibb Company ; 2018 .
103.Cresemba [package insert] . Northbrook, IL : Astellas Pharma US, Inc ; 2018 .
104.Ixempra Kit [package insert] . Princeton, NJ : R-Pharm US LLC ; 2016 .
105.Aldurazyme [package insert] . Cambridge, MA : Genzyme Corporation ; 2018 .
106.Intralipid [package insert] . Deerfield, IL : Baxter Healthcare Corporation ; 2016 .
107.Nutrilipid [package insert] . Bethlehem, PA : B. Braun Medical Inc ; 2014 .
108.Omegaven [package insert] . Lake Zurich, IL : Fresenius Kabi USA, LLC ; 2018 .
109.Smoflipid [package insert] . Lake Zurich, IL : Fresenius Kabi USA, LLC ; 2018 .
110.
Cohen
MR
Smetzer
JL.
Selected medication safety risks to manage in 2016: part I intravenous fat emulsion needs a filter . Hosp Pharm . 2016 ;51 (5 ):353 -357 .
111.Atgam [package insert] . New York, NY : Pharmacia & Upjohn Co ; 2018 .
112.Drugs to be used with a filter for preparation and/or administration . Hosp Pharm . 2007 ;42 (4 ):378 -382 .
113.Mannitol [package insert] . Lake Forest, IL : Hospira, Inc ; 2015 .
114.Osmitrol [package insert] . Deerfield, IL : Baxter Healthcare Corporation ; 2018 .
115.Mannitol [package insert] . Bethlehem, PA : B. Braun Medical Inc ; 2016 .
116.Mannitol [package insert] . Schaumburg, IL : Fresenius Kabi USA, LLC ; 2008 .
117.Provocholine [package insert] . Brantford, Ontario, Canada : Methapharm Inc ; 2017 .
118.Poteligeo [package insert] . Bedminster, NJ : Kyowa Kirin Inc ; 2018 .
119.Opdivo [package insert] . Princeton, NJ : Bristol-Myers Squibb Company ; 2018 .
120.Anthim [package insert] . Pine Brook, NJ : Elusys Therapeutics, Inc ; 2016 .
121.Ocrevus [package insert] . South San Francisco, CA : Genentech Inc ; 2017 .
122.Paclitaxel [package insert] . Lake Zurich, IL : Fresenius Kabi USA, LLC ; 2017 .
123.Abraxane [package insert] . Summit, NJ : Celgene Corporation ; 2018 .
124.Vectibix [package insert] . Thousand Oaks, CA : Amgen Inc ; 2017 .
125.Onpattro [package insert] . Cambridge, MA : Alnylam Pharmaceuticals, Inc ; 2018 .
126.Keytruda [package insert] . Whitehouse Station, NJ : Merck & Co. Inc ; 2018 .
127.Phenytoin sodium [package insert] . Eatontown, NJ : West-Ward Pharmaceuticals Corporation ; 2017 .
128.Noxafil [package insert] . Whitehouse Station, NJ : Merck & Co. Inc ; 2017 .
129.Cyramza [package insert] . Indianapolis, IN : Eli Lilly and Company ; 2018 .
130.Lucentis [package insert] . South San Francisco, CA : Genentech Inc ; 2018 .
131.Ultomris [package insert] . Boston, MA : Alexion Pharmaceuticals, Inc ; 2018 .
132.Cinqair [package insert] . Frazer, PA : Teva Pharmaceuticals ; 2016 .
133.Kanuma [package insert] . New Haven, Ct : Alexion Pharmaceuticals Inc ; 2015 .
134.Sylvant [package insert] . Horsham, PA : Janssen Biotech Inc ; 2018 .
135.Elzonris [package insert] . New York, NY : Stemline Therapeutics, Inc ; 2018 .
136.Elelyso [package insert] . New York, NY : Pfizer Inc ; 2016 .
137.RadioGenix System [package insert] . Beloit, WI : NorthStar Medical Radioisotopes LLC ; 2018 .
138.Torisel [package insert] . Philadelphia, PA : Wyeth Pharmaceuticals Inc ; 2018 .
139.Tepadina [package insert] . Bridgewater, NJ : Amneal Biosciences LLC ; 2017 .
140.Thiotepa [package insert] . Princeton, NJ : Dr. Reddy’s Laboratories Inc ; 2018 .
141.Thiotepa [package insert] . Schaumburg, IL : Sagent Pharmaceuticals, Inc ; 2018 .
142.Thiotepa [package insert] . Eatontown, NJ : West-Ward Pharmaceuticals Corp ; 2015 .
143.Yondelis [package insert] . Horsham, PA : Janssen Products LP ; 2018 .
144.Remodulin [package insert] . Research Triangle Park, NC : United Therapeutics Corp ; 2018 .
145.Stelara [package insert] . Horsham, PA : Janssen Biotech Inc ; 2018 .
146.Vpriv [package insert] . Lexington, MA : Shire Human Genetic Therapies Inc ; 2015 .
147.Visudyne [package insert] . Bridgewater, NJ : Bausch + Lomb ; 2016 .
148.Mepsevii [package insert] . Novato, CA : Ultragenyx Pharmaceutical Inc ; 2017 .
149.Marqibo kit [package insert] . Irvine, CA : Talon Therapeutics Inc ; 2016 .
150.Vincasar PFS [package insert] . North Wales, PA : Teva Pharmaceuticals USA, Inc ; 2014 .
151.Zaltrap [package insert] . Bridgewater, NJ : Sanofi-Aventis US LLC ; 2016 .
152.Amphotericin B desoxycholate [package insert] . Big Flats, NY : X-GEN Pharmaceuticals, Inc ; 2010 .
153.Cinryze Resource Library . https://www.cinryze.com/hae-resources/. Published December 2018. Accessed May 3, 2019 .
154.US Food & Drug Administration . Drugs@FDA: FDA approved drug products . https://www.accessdata.fda.gov/scripts/cder/daf/. Accessed May 3, 2019 .
155.CenterWatch . FDA approved drugs . https://www.centerwatch.com/drug-information/fda-approved-drugs/. Accessed May 3, 2019 .
156.US Food & Drug Administration . New drugs at FDA: CDER’s new molecular entities and new therapeutic biological products . https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DrugInnovation/default.htm. Accessed May 3, 2019 .
157.US Food & Drug Administration . Purple book: lists of licensed biological products with reference product exclusivity and biosimilarity or interchangeability evaluations . https://www.fda.gov/drugs/developmentapprovalprocess/howdrugsaredevelopedandapproved/approvalapplications/therapeuticbiologicapplications/biosimilars/ucm411418.htm. Accessed May 3, 2019 .
158.US Pharmacopeia . General chapter <797> . https://www-uspnf-com.proxy.cc.uic.edu/. Accessed February 15, 2019 .