Dofetilide’s hepatotoxicity is not well described. In this case report, we describe acute hepatocellular jaundice related to dofetilide use in a 33-year-old male being treated for atrial fibrillation. Both viral and ischemic causes of hepatocellular damage were ruled out as unlikely in this case. This case report outlines a rare yet probable report of idiosyncratic dofetilide-induced liver injury.
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ChalasaniNPHayashiPHBonkovskyHLet al. ACG clinical guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol. 2014;109(7):950-966; quiz 967.
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WalkerDKAlabasterCTCongraveGSet al. Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data. Drug Metab Dispos. 1996;24(4):447-455.
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ZimmermanHJ. Heparin. Drugs used in cardiovascular disease. In: ZimmermanHJ, ed. Hepatotoxicity: the Adverse Effects of Drugs and Other Chemicals on the Liver. 2nd ed.Philadelphia, PA: Lippincott; 1999:639-412.
