Ezetimibe/Simvastatin

Abstract

Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late Phase III trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation (DUE) is also provided each month. With a subscription, the monographs are sent to you in print and CD ROM forms and are available online. Monographs can be customized to meet the needs of your facility. Subscribers to the The Formulary Monograph Service also receive access to a pharmacy bulletin board, The Formulary Information Exchange (The F.I.X.). All topics pertinent to clinical and hospital pharmacy are discussed on The F.I.X.

Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. If you would like information about The Formulary Monograph Service or The F.I.X., call The Formulary at 800-322-4349. The November 2004 monograph topics are erlotinib hydrochloride, clodronate, oxypurinol sodium, pegaptanib sodium injection, and ramelteon. The DUE is on ezetimibe/simvastatin.

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References

Vytorin (ezetimibe/simvastatin) [package insert]. Whitehouse Station, NJ/Kenilworth, NJ: Merck/Schering-Plough Pharmaceuticals; July 2004.

Kosoglou

, Meyer

, Veltri

E.P.

Pharmacodynamic interaction between the new selective cholesterol absorption inhibitor ezetimibe and simvastatin.

Br J Clin Pharmacol. 2002; 54(3): 309–19.

Sager

P.T.

, Melani

, Lipka

Effect of coadministration of ezetimibe and simvastatin on high-sensitivity C-reactive protein.

Am J Cardiol. 2003; 92(12): 1414–18.

Goldberg

A.C.

, Sapre

, Liu

, Capece

, Mitchel

Y.B.

Efficacy and safety of ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia: a randomized, double-blind, placebo-controlled trial.

Mayo Clin Proc. 2004; 79(5): 620–9.

Crestor (rosuvastatin calcium) [package insert]. Waltham, MA: AstraZeneca Pharmaceuticals LP; August 2003.

Lipitor (atorvastatin calcium) [package insert]. New York, NY: Pfizer Pharmaceuticals; August 2003.

Zocor (simvastatin) [package insert]. Whitehouse Station, NJ: Merck & Co.; April 2003.

Zetia (ezetimibe) [package insert]. Whitehouse Station, NJ/Kenilworth, NJ: Merck/Schering-Plough Pharmaceuticals; March 2003.

Bays

H.E.

, Ose

, Fraser

Ezetimibe/simvastatin therapy is more effective than simvastatin alone at reducing remnant-like particle cholesterol [abstract].

J Am Coll Cardiol. 2004; 43(5 suppl A): 481A.

10.

Goldberg

A.C.

, Capece

, Sapre

Efficacy of ezetimibe-10 mg/day coadministered with multiple doses of simvastatin in patients with primary hypercholesterolemia [abstract].

J Am Coll Cardiol. 2004; 43(5 suppl A): 480A.

11.

Davidson

M.H.

, McGarry

, Bettis

Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia.

J Am Coll Cardiol. 2002; 40(12): 2125–34.

12.

Feldman

, Koren

, Insull

Jr ,

Treatment of high-risk patients with ezetimibe plus simvastatin co-administration versus simvastatin alone to attain National Cholesterol Education Program Adult Treatment Panel III low-density lipoprotein cholesterol goals.

Am J Cardiol. 2004; 93(12): 1481–6.

13.

Ballantyne

C.M.

, Blazing

M.A.

, King

T.R.

, Brady

W.E.

, Palmisano

Efficacy and safety of ezetimibe co-administered with atorvastatin in adults with hypercholesterolemia.

Am J Cardiol. 2004; 93(12): 1487–94.

14.

Masana

, Mata

, Gagne

Long-term safety and efficacy of ezetimibe added to ongoing simvastatin treatment [abstract].

Atherosclerosis. 2003; 4(suppl): 238.

15.

Gaudiani

, Lewin

, Meneghini

Efficacy and safety of ezetimibe coadministered with simvastatin versus simvastatin alone in thiazolidinedione-treated patients with type 2 diabetes mellitus [abstract].

J Am Coll Cardiol. 2004; 43(5 suppl A): 479A.

16.

Dobs

A.S.

, Guyton

J.R.

, McClusky

Coadministration of ezetimibe with simvastatin [abstract].

J Am Coll Cardiol. 2003; 41(6 suppl A): 227A.

17.

Kastelein

, Sager

, De Groot

, Veltri

The ENHANCE trial: Ezetimibe and simvastatin in hypercholesterolemia enhances atherosclerosis regression [abstract].

Atherosclerosis. 2003; 4(suppl): 341.

18.

Gagne

, Gaudet

, Bruckert

Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia.

Circulation. 2002; 105(21): 2469–75.

19.

Landray

M.J.

, Baigent

, Leaper

Biochemical safety and efficacy of co-administration of ezetimibe and simvastatin among patients with chronic kidney disease: The Second UK-Heart and Renal Protection (UK-HARP-II) Study [abstract].

Circulation. 2003; 108(17 suppl S): 736.