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Abstract

Purpose

This study identified factors that contributed to bleeding complications associated with warfarin therapy that were documented as adverse drug reactions (ADRs).

Methods

A retrospective chart review was performed using the Medical Records Department's “E” code list of anticoagulant-related ADRs. Descriptive statistics were used to identify common factors associated with bleeding complications related to warfarin use.

Results

Patients 60 years of age or older experienced 78% of all events; a majority (81%) of reports involved the presence of comorbid conditions such as congestive heart failure, carcinoma, or sepsis. A supratherapeutic INR was documented for 75% of patients with anticoagulant-related ADRS.

Conclusions

Age, comorbid conditions, and anticoagulation intensity were identified as possible factors contributing to documented ADRs associated with warfarin therapy.

Keywords

anticoagulation therapy adverse drug reactions warfarin

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A Descriptive Report of Bleeding Complications Secondary to Warfarin Therapy

Abstract

Purpose

Methods

Results

Conclusions

Keywords

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References