The increasing complexity of cancer chemotherapy makes it mandatory that pharmacists be familiar with these highly toxic agents. This column reviews various issues related to the preparation, dispensing, and administration of cancer chemotherapy, both commercially available and investigational.
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References
1.
PinkelD.The use of body surface area as a criterion of drug dosage in cancer chemotherapy. Cancer Res.1958; 18: 853–6.
2.
FreireichE.J., GehanE.A., RallDPmQuantitative comparison of toxicity of anticancer agents in mouse, rat, hampster, dog, monkey and man. Cancer Chemother Rep.1966; 50: 219–44.
3.
Du BoisD., du BoisE.F.A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med.1916; 17: 863–71.
4.
DawsonW.T.Relations between age and weight and dosage of drugs. Ann Int Med.1940; 13: 1594–1613.
5.
CrawfordJ.D., TerryM.E., RorkeG.M.Simplification of drug dosage calculation by application of the surface area principle. Pediatrics.1950; 5: 783–9.
6.
TurcotteG.Erroneous nomograms for body-surface area. N Engl J Med.1979; 300: 1339.
7.
MostellerR.D.Simplified calculation of body-surface area. N Engl J Med.1987; 317(17): 1098.
8.
LamT.K., LeungD.T.More on simplified calculation of body-surface area. N Engl J Med.1988; 318(17): 1130.
9.
JelliffeR.W.Creatinine clearance: bedside estimate. Ann Intern Med.1973; 79: 604–5.
10.
GelmanR.S., TormeyD.C., BetenskyR.Actual versus ideal body weight in the calculation of surface area: effects on dose of 11 chemotherapy agents. Cancer Treat Rep.1987; 71(10): 907–11.
11.
SmithT.J., DeschC.E.Neutropenia-wise and pound-foolish. Safe and effective chemotherapy in massively obese patients. Southern Med J.1991; 84: 883–5.
12.
TuckerG.R., AlexanderJ.K.Estimation of body surface area in extremely obese subjects. J Appl Physiol.1960; 15: 781–4.
13.
GeorgiadisM.S.Obesity and therapy-related toxicity in patients treated for small-cell lung cancer. J Natl Cancer Inst.1995; 87: 361–6.
14.
RosnerG.L.Relationship between toxicity and obesity in women receiving adjuvant chemotherapy for breast cancer: results from Cancer and Leukemia Group B study 8541. J Clin Oncol.1996; 14: 3000–8.
15.
VaughnW.P.Body surface area (BSA) dosing using actual body weight (ABW) yields less variation in the area nder the concentration x time curve (AUC) for high dose IV busulfan (BU) than BSA dosing using ideal body weight (IBW), adjusted ideal body weight (AIBW) or dosing using ABW, IBW, or AIBW directly. Proc Am Soc Clin Oncol.1999; 18: 191a.
16.
O'MarcaighA.S., GilchristG.S.Dose reduction of chemotherapeutic agents after weight loss. Am J Clin Oncol.1997; 20(2): 193–5.
17.
WallaceA.B.The exposure treatment of burns. Lancet.1951; 1: 501–4.
18.
ColangeloP.M., WelchD.W., RichD.S.Two methods for estimating body surface area in adult amputees. Am J Hosp Pharm.1984; 41(12): 2650–5.
19.
HutsonP.R.Using body surface area adjustments in amputees. Am J Hosp Pharm.1985; 42(5): 1048–9.
20.
RatainM.J.Body-surface area as a basis for dosing of anticancer agents: Science, myth, or habit?J Clin Oncol.1998; 16(7): 2297–8.
21.
GurneyH.Dose calculation of anticancer drugs: A review of the current practice and introduction of an alternative. J Clin Oncol.1996; 14(9): 2590–611.
22.
BurkeG.A., EstlinE.J., LowisS P.The role of pharmacokinetic and pharmacodynamic studies in the planning of protocols for the treatment of childhood cancer. Cancer Treat Rev.1999; 25(1): 13–27.
23.
BerghJ.Tailored chemotherapy to equal toxicity: is it possible?Recent Results Cancer Res.1998; 152: 328–40.
CanalP., ChatelutE., GuichardS.Practical treatment guide for dose individualisation in cancer chemotherapy. Drugs.1998; 56(6): 1019–38.
26.
GehanE.A., GeorgeS.L.Estimation of human body surface area from height and weight. Cancer Chemother Rep.1970; 54: 225–35.
27.
MitchellD., StrydonN.B., Van GraunC.H.Human surface area: Comparison of the DuBois formula with direct photometric measurement. Pflugers Arch.1971; 325: 852–7.
28.
HaycockG.B., SchwartzG.J., WisotskyD.H.Geometric method for measuring body surface area: A height-weight formula validated in infants, children, and adults. J Pediatr.1978; 93: 62–6.
29.
GrochowL.B., BaraldiC., NoeD.Is dose normalization to weight or body surface area useful in adults?J Natl Cancer Inst.1990; 82: 323–5.
