Anorexia nervosa and bulimia are common conditions that are difficult to treat effectively. Psychopharmacologic agents, particularly tricyclic antidepressants, are now being used as adjunctive therapy in bulimia. The case of a 15-year-old girl with bulimia who was treated with imipramine and had a severe (and first) manic episode is presented. The complication of drug-induced mania observed in patients treated with tricyclic antidepressants is discussed.
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References
1.
Office of Research Reporting. National Institutes of Child Health and Human Development.Facts about Anorexia Nervosa. Bethesda, MD: National Institutes of Health. 1983.
2.
Crisp AH, Palmer RL, Kalucy RSHow common is anorexia nervosa? A prevalence study. Br J Psychiatry1976;128:549-54.
3.
Stangler RS, Printz AMDSM III psychiatric diagnosis in university population. Am J Psychiatry1980;137:937-40.
4.
Pope HG, Hudson JI, Yurgelem-Todd D.Anorexia nervosa and bulimia among 300 suburban women shoppers. Am J Psychiatry1984;141:292-4.
5.
Halmi KA, Falk JR, Schwartz E.Binge-eating and vomiting: A survey of a college population. Psychol Med1981;11:697-706.
6.
Diagnostic and Statistical Manual of Mental Disorders. Third Edition. Washington, DC: American Psychiatric Association. 1980, 69-71.
7.
Johnson C., Stuckey M., Mitchell J.Psychopharmacological treatment of anorexia nervosa and bulimia: Review and synthesis. J Nerv Ment Dis1983;171:524-34.
8.
Conner CSTreatment of bulimia. Drug Intell Clin Pharm1983;17:815-6.
9.
Pope HG, Hudson JLTreatment of bulimia with antidepressants. Psychopharmacology1982;78:176-9.
10.
Pope HG, Hudson JI, Jonas JM, et al. Bulimia treated with imipramine: A placebo controlled, double-blind study. Am J Psychiatry1983;140:554-8.
11.
Hudson JI, Pope HG, Jonas JMTreatment of bulimia with antidepressants: Theoretical considerations and clinical findings. Psychiatric Annals1983 ;13:965-9.
12.
Pyle RL, Mitchell JE, Eckert EDBulimia: A report of 34 cases. J Clin Psychiatry1981;42:60-4.
13.
Herzog DBBulimia: The secretive syndrome. Psychosomatics1982;23:481-7.
14.
Hudson JI, Laffer PS, Pope HGBulimia related to affective disorder by family history and response to the dexamethasone suppression test. Am J Psychiatry1982;139:685-7.
15.
Kashani JH, Burk JP, Reid JCDepressed children of depressed parents. Can J Psychiatry1985;30:265-8.
16.
Stern SL, Dixon KN, Nemzer E., et al. Affective disorder in the families of women with normal weight bulimia. Am J Psychiatry1984;141:1224-7.
17.
Killen JD, Taylor CB, Telch MJ, et al. Depressive symptoms and substance use among adolescent binge eaters and purgers: A defined population study. Am J Public Health1987;77:1589-41.
18.
Hudson JI, Pope HG, Yurgelun-Todd D., et al. A controlled study of lifetime prevalence of affective and other psychiatric disorders in bulimic outpatients. Am J Psychiatry1987;144:1283-7.
19.
Bunney WEPsychopharmacology of the switch process in affective illness. In: Lipton MA, DiMascio A, Killam KF (Eds). Psychopharmacology: A Generation of Progress. New York: Raven. 1978, 1249-59.
20.
Wehr TA, Goodwin FKRapid cycling in manic-depressives induced by tricyclic antidepressants. Arch Gen Psychiatry1979;36:555-9.
21.
vanScheyen JD, vanKammen DP. Clomipramine-induced mania in unipolar depression. Arch Gen Psychiatry1979 ;36:560-5.
22.
Extein I., Potter WZ, Wehr TA, et al. Rapid mood cycles after a noradrenergic but not a serotonergic antidepressant. Am J Psychiatry1979;136:1602-3.
23.
Wehr TA, Goodwin FKCan antidepressants cause mania and worsen the course of affective illness?Am J Psychiatry1987;144:1403-11.
24.
Settle EC Jr, Settle GPA case of mania associated with fluoxetine. Am J Psychiatry1984;141:280-1.
25.
Goff DCTwo cases of hypomania following the addition of 1-tryptophan to a MAO-inhibiter . Am J Psychiatry1985;142:1487-8.
26.
Steinberg S. , Chouinard G.A case of mania associated with tomoxetine . Am J Psychiatry1985;142:1517-8.
27.
Nasrallah HA , Lyskowski J., Schroeder D.TCA-induced mania: Differences between switchers and nonswitchers. Biol Psychiatry1982;17:271-4.
