Clinical Characteristics and Serum Essential Fatty Acid Levels in Hyperactive Children

Abstract

This study compared 48 hyperactive children with 49 age-and-sex-matched controls. Significantly more hyperactive children had auditory, visual, language, reading, and learning difficulties, and the birth weight of hyperactive children was significantly lower than that of controls (3,058 and 3,410 g, respectively; p < 0.01). In addition, significantly more hyperactive children had frequent coughs and colds, polydypsia, polyuria, and a serious illness or accident in the past year than controls, but there was no increase in asthma, eczema, or other allergies. Serum essential fatty acid (EFA) levels were measured in 44 hyperactive subjects and 45 controls. The levels of docasahexaenoic, dihomogammalinolenic, and arachidonic acids were significantly lower in hyperactive children than controls (docosahexaenoic: 41.6 and 49.5 μg/ml serum respectively, p = 0.045; dihomogammolinolenic: 34.9 and 41.3 μg/ml serum, p = 0.007; arachidonic : 127.1 and 147.0 μg/ml serum, p = 0.027). These findings have possible therapeutic and diagnostic implications, but further research is needed to attempt to replicate these differences.

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References

Diagnostic and Statistical Manual of Mental Disorders (DSM-III). Washington DC. American Psychiatric Association, 1980;45-51.

Prior M. Identification and treatment of hyperactive children. Aust Paediatr J 1982;18:13-6.

Levine MD , Oberklaid F. Hyperactivity.

Symptom complex or complex symptom?

Am J Dis Child 1980; 134:409-14.

Colquhoun I. , Bunday S. A lack of essential fatty acid as a possible cause of hyperactivity in children . Med Hypotheses 1981;7:673-9.

Mitchell EA , Lewis S. , Cutler DR Essential fatty acids and maladjusted behavior in children. Prostaglandins Leukotrienes Med 1983; 12:281-7.

Feingold BF Why Your Child is Hyperactive. New York: Random House, 1975.

Pudelkowics C. , Senfert J. , Holman RT Requirements of the female rat for linoleic and linolenic acids. J Nutr 1968;64:138.

Horrobin DF The regulation of prostaglandin biosynthesis. Negative feedback mechanism and the selective control of the formation of 1 and 2 series prostaglandins: relevance to inflammation and immunity. Med Hypotheses 1980; 6:687-709.

Huang YS , Cunnane SC , Horrobin DF , et al. Most biological effects of zinc deficiency corrected by gamma-linolenic acid but not by linoleic acid. Atherosclerosis 1982;41:193-207.

10.

Zioudrou C. , Streaty RA , Klee WA Opioid peptides derived from food proteins: the exorphins. J Biol Chem 1979;254:2446-9.

11.

Quay HC A dimensional approach to children's behavior disorders: the Revised Behavior Problem Checklist. School Psychology Rev 1982 ;12:244-9.

12.

Conners CK Symptom patterns in hyperkinetic, neurotic and normal children. Child Dev 1970;41:667-82.

13.

Aman MG , Werry JS , Fitzpatrick J. , et al. Factor structure and norms for the Revised Behavior Problem Checklist in New Zealand children. Aust NZ J Psychiatry 1983;17:354-60.

14.

Werry JS , Hawthorne D. Conners Teacher questionnaire-Norms and validity. Aust NZ J Psychiatry 1976;10:257-62.

15.

Manku MS , Horrobin DF , Huang YS , et al. Fatty acids in plasma and red cell membranes in normal humans . Lipids 1983;18:906-8.

16.

Elley WB , Irving JC A socioeconomic index for New Zealand based on levels of education and income from the 1966 census. NZJ Educ Studies 1972 ;7:153-67.

17.

Lambert NM , Sandoval J. , Sassone D. Prevalence of hyperactivity in elementary school children as a function of social system definers. Am J Orthopsychiatry 1978;48:446-63.

18.

Aman MG , Werry JS The Revised Behavior Problem Checklist in clinic attenders and non-attenders . Age and sex effects. J Clin Child Psychol 1984;13:237-42.

19.

Schleifer M. , Weiss G. , Cohen N. , et al. Hyperactivity in preschoolers and the effect of methylphenidate. Am J Orthopsychiatry 1975;45:38-50.

20.

Pasamanick B. , Knobloch H. Brain damage and reproductive casualty . Am J Orthopsychiatry 1960;30:298-305.

21.

Sameroff A. , Chandler M. Reproductive risk and the continuum of caretaking casualty. In: Horowitz F , ed. Annual Review of Child Development Research, Vol. 4. Chicago: University of Chicago Press, 1975.

22.

Martin CA , Welsh RJ , McKay SE , et al. Hyperactivity (Attention deficit disorder). J Fam Pract 1984;19:367-80.

23.

Rapp DJ

Does diet affect hyperactivity?

J Learn Disab 1978;11:56-62.

24.

Trites RK , Tryphonas J. , Ferguson HB Diet treatment for hyperactive children with food allergies. In: Knights RM & Bakker DJ , eds. Treatment of Hyperactive and Learning Disordered Children. Baltimore: University Park Press, 1980.

25.

Mitchell EA Increasing prevalence of asthma in children . NZ Med J 1983;96:463-4.

26.

Manku MS , Horrobin DF , Morse N. , et al. Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy. Prostaglandins Leukotrienes Med 1982 ;9:615-28.

27.

Lloyd-Still JD , Johnson SB , Holman RT Essential fatty acid status in cystic fibrosis and the effects of safflower oil supplementation . Am J Clin Nutr 1981;34:1-7.

28.

Aman MG , Mitchell EA , Turbott SH The effects of essential fatty acid supplementation by Efamol in hyperactive children. J. Abnorm Child Psychol 1987;15:75-90.