A premature infant with hypoplasia of the right heart and pulmonary arteries required treatment with prostaglandin E1 (PGEI) for 107 days prior to surgical intervention. Digital swelling was noted at 40 days of age. Swelling was measured by determining the ratio of the distal phalangeal depth to interphalangeal depth. The ratio declined from 1.16 to 0.94 in the first 64 days after treatment. We believe digital swelling is a reversible complication of PG therapy.
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References
1.
Freed MD, Heymann MA, Lewis AB et al. Prostaglandin E1 in infants with ductus arteriosus-dependent congenital heart disease. Circulation1981 ;64:899-904.
2.
Lewis AB, Freed MD, Heymann, MA et al. Side effects of therapy with prostaglandin E1 in infants with critical congenital heart disease. Circulation1981;64:893-8.
3.
Hoevels-Guerich H., Haferkorn L., Persigehl M. et al. Widening of cranial sutures after long-term prostaglandin E2 therapy in two newborn infants. J Pediatr1984;105:72-4.
4.
Ringel RE, Brenner JI, Haney PJ et al. Prostaglandin-induced periostitis: a complication of long-term PGE1 infusion in an infant with congenital heart disease. Radiology1982;142:657-8.
5.
Ueda K., Saita A., Nakano H. et al. Cortical hyperostosis following long-term administration of prostaglandin E1 in infants with cyanotic congenital heart disease . J Pediatr1980;97:834-6.
6.
Fariello R., Olley PM, Coceani F.Neurological and electroencephalographic changes in newborns treated with prostaglandins E1 and E2. Prostaglandins1977;13:901-7.
7.
Lemen RJ, Gates AJ, Mathe AA et al. Relationships among digital clubbing, disease severity, and serum prostaglandins F2a and E concentrations in cystic fibrosis patients. Am Rev Resp Dis1978; 117:639-46.
8.
Shneerson JMDigital clubbing and hypertrophic osteoarthropathy: the underlying mechanisms. Br J Dis Chest1981;75:113-9.
9.
Waring WW, Wilkinson RW, Wiebe RA, et al. Quantitation of digital clubbing in children. Measurements of the index finder. Am Rev Resp Dis1971;104:166-74.
10.
Jureidini S. , Alpert BS, Vanderzalm T.Unusual soft tissue swelling in a neonate following prolonged therapy with prostaglandin E 1. Pediatr Cardiol (accepted for publication).
11.
Tomiie F., Yamamoto A., Murakami K.Bone changes in infants induced by prostaglandin E1 as secondary hypertrophic osteoarthropathy. Nippon Igaku Hoshasen Gakkai Zasshi1982;42:1127-36.
12.
Guida B., Piersantelli N.Si di una sindrome paraeoplastica trattata con indometacina. Clin Terap1976;79:381.
13.
Burchfield D., Wu-Wang C., Neu J., et al. Prostaglandin E productions in response to furosemide. Clin Res1986;34:254A .
