Two young children are described in whom chronic diarrhea associated with the presence of Clostridium difficile toxin responded to treatment with oral van comycin. C. difficile infection should be considered in the evaluation of young children with diarrhea who fail to gain weight, even in the absence of prior antibiotic treatment.
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References
1.
Adler SP, Chandrika T., Berman WFClostridium difficile associated with pseudomembranous colitis. Am J Dis Child1981;135:820.
2.
Hyams JS, Berman M., Helgason H.Nonantibiotic-associated enterocolitis caused by Clostridium difficile in an infant. J Pediatr1981;99:750.
3.
Bartlett JG, Chang T., Taylor NS, et al. Colitis induced by Clostridium difficile. Rev Infect Dis1979;1:370.
4.
Sills RHFailure to thrive: the role of clinical and laboratory evaluation . Am J Dis Child1978;132:967.
5.
Lloyd-Still JDChronic diarrhea of childhood and the misuse of elimination diets. J Pediatr1979;95:10.
6.
Kim K-H., Fekety R., Batts DH, et al. Isolation of Clostridium difficile from the environment and contacts of patients with antibiotic-associated colitis. Infect Dis1981;143:42.
7.
Gilligan PH, McCarthy LR, Genta VMRelative frequency of Clostridium difficile in patients with diarrheal disease . J Clin Microbiol1981;14:26.
8.
Falsen E., Kaijser B., Nehls L., et al. Clostridium difficile in relation to enteric bacterial pathogens . J Clin Microbiol1980;12:297.
9.
Rietra Pjgm, Slaterus KW, Zanen HC, et al. Clostridial toxin in faeces of healthy infants. Lancet1978;2:319.
10.
Viscidi R., Willey S., Bartlett JGIsolation rates and toxigenic potential of Clostridium difficile isolates from various patient populations. Gastroenterology1981;81:5.
11.
Welch DF, Marks MIIs Clostridium difficile pathogenic in infants?J Pediatr1982;100:393.
Sutphen JS, Grand RJNew identification of C difficile as a cause of chronic diarrhea without classic signs of colitis. Pediatr Res1981 ;15:622.
14.
Thompson CM, Gilligan PH, Fisher MC, Long SSClostridium difficile in a pediatric population [abstract]. In: Program and Abstracts of the 21st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Nov 4-6, 1981. Washington DC: American Society for Microbiology, 1981.
15.
Sutphen JL, Grand RJ, Flores A., et al. Chronic diarrhea associated with Clostridium difficile in children . Am J Dis Child1983; 137:275.
16.
Thompson CM Jr, Gilligan PH, Fisher MC, et al. Clostridium difficile cytotoxin in a pediatric population. Am J Dis Child1983 ; 137:271.
