Cefaclor and rifampin were measured in the serum and saliva of healthy adult volunteers after ingestion of a liquid formulation and again after capsules of the drugs were given. Antimicrobially active drug was present in most salivary samples after ingestion of suspension of both drugs; however, only rifampin appeared in saliva after ingestion of the capsules. These data correlate with clinical studies of Hemophilus influenzae type b chemoprophylaxis and provide an expla nation of the efficacy of rifampin and the inability of cefacior to eradicate pharyngeal carriage of Hemophilus strains.
Get full access to this article
View all access options for this article.
References
1.
Granaff DM, Daum RSSpread of Haemophilus influenzae type b: recent epidemiologic and therapeutic considerations. J Pediatr1980;97:854.
2.
Horner DB, Ginsburg CM, McCracken GH, Zweighaft TCA comparison of three antibiotic regimens for eradication of Haemophilus influenzae type b from the pharynx of infants and children. Pediatrics1980;66:136-8.
3.
Band JDPrevention of Haemophilus influenzae type b disease by rifampin. Proceedings of 2 1 st Interscience Conference on Antimicrob Agents and ChemotherChicago, Illinois, 1981 .
4.
Hoeprich PDPrediction of antimeningococcic chemoprophy-Iactic eacacy. J Infect Dis1971;123:125.
5.
McCracken GH , Ginsburg CM, Clahsen JC, Thomas MLPharmacokinetics of cefaclor in infants and children. J Antimicrob Chemother1978;4:515.
6.
Simon HJ, Yin EJMicrobioassay of antimicrobial agents. Appl Microbiol1970;19:573.
7.
McCracken GH , Ginsburg CM, Zweighaft TC, Clahsen JCPharmacokinetics in rifampin in infants and children: relevance to prophylaxis against Haemophilus influenzae type b disease . Pediatrics1980 ,66:17.
8.
Yogev R., Melick C.Persistence of nasopharyngeal carriage of Haemophilus influenzae type b following cefaclor therapy. (abstr)Pediatr Res1980 ;14:567.
9.
Granoff D., Gilsdorf J., Gessert C., Basden M.Hemophilus influenzae type b disease in a day-care center: eradication of carrier state by rifampin. Pediatrics1979 ;63:397.
10.
Shapiro ED, Wald EREfficacy of rifampin in eliminating pharyngeal carriage of Haemophilus influenzae type b. Pediatrics1980;66:5.
