A 3-day-old infant presented with Arizona hinshawii sepsis and meningitis. Despite parenteral chloramphenicol, A. hinshawii persisted in the cerebro spinal fluid and blood until trimethoprim-sulfamethoxazole was added. Three weeks following discharge the infant returned and A. hinshawii was re- cultured from the blood and cerebrospinal fluid. Chloramphenicol and tri methoprim-sulfamethoxazole was re-instituted and the infant recovered. This report demonstrates the potentially serious consequences of A. hinshawii infections in the neonate and emphasizes the need for proper identifica tion of this organism with appropriate biochemical tests and individualization of antimicrobial therapy.