Antibiotic Susceptibilities of 120 Strains of Staphylococcus Aureus Isolated from Patients at a Children's Hospital

Abstract

The antibiotic sensitivities of 120 strains of Staphylococcus aureus isolated from both hospitalized patients and outpatients at Children's Memorial Hospital, Oklahoma City were studied. The proportions of strains resistant to the commonly used antibiotics were considerably lower than that found by other workers in earlier years, except for penicillin G. Of the 120 strains, 98 (81.7%) were resistant to penicillin G, 13 (10.8%) to tetracycline, 9 (7.5%) to erythromycin, and 3 (2.5%) to clindamycin. No strains resistant against cephalothin, chloramphenicol, gentamicin, or oxacillin were found. Sixteen strains (13.3 %), of which 5 were inpatient strains and 11 were outpatient strains, were found to be resistant to more than one drug. Phage group 1 or type 80/81 staphylococci were not found among multiple resistant strains from hospitalized patients.

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References

Bulger, R.J. , and Sherris, J.G. : Decreased incidence of antibiotic resistance among Staphylococcus aureus. Ann. Intern. Med. 69: 1099, 1968.

Barrett, F.F. , Casey, J.I. , Wilcox, C. , et al.: Bacteriophage type and antibiotic susceptibility of Staphylococcus aureus, Boston City Hospital, 1967. Arch. Intern. Med. 125: 867, 1970.

Wallmark, G. , and Finland, M. : Phage types and antibiotic susceptibility of pathogenic staphylococci. Results at Boston City Hospital 1959-1960 and comparison with strains of previous years. JAMA 175: 886, 1961.

Barrett, F.F. , McGehee, R.F. , Jr., and Finland , M. : Methicillin-resistant Staphylococcus aureus at Boston City Hospital. Bacteriologic and epidemiologic observations. N. Engl. J. Med. 279: 441, 1968 .

Nahmias, S.J. , and Eickhoff, T.C. : Staphylococcal infections in hospitals. Recent developments in epidemiologic and laboratory investigation. N. Engl. J. Med. 265: 74, 120, 1961.

Finland, M. , Jones, W.F. , and Barnes, M.W. : Occurrence of serious bacterial infections since introduction of antibacterial agents. JAMA 170: 2188, 1959.

McNamara, M.J. , Hill, M.D. , Balow, A. , et al.: Study of bacteriologic patterns of hospital infections. Ann. Intern. Med. 66: 480, 1967.

Barrett, F.F. , Casey, J.I. , and Finland, M. : Infections and antibiotic use among patients at Boston City Hospital. February 1967. N. Engl. J. Med. 278: 5, 1968.

Barber, M. , Dutton, A.A.C. , Beard, M.A. , et al.: Reversal of antibiotic resistance in hospital staphylococcal infection. Br. Med. J. 1: 11, 1960.