Progress in prolonging the lives of children with leukemia has resulted in a great increase in neurological complications. Exact diagnosis and intensive therapy are needed. Prophylactic CNS therapy offers bright new hope for prolonged survival or cure.
Get full access to this article
View all access options for this article.
References
1.
Evans, A., Gilbert, E. and Zandstra, R.: The increasing incidence of central nervous system leukemia in children. Cancer26: 404, 1970.
2.
Evans, A.: The cerebrospinal fluid of leukemic children without central nervous system manifestations. Pediatrics31: 1024, 1963.
3.
Hyman, C., Bogle, J., Brubaker, C. et al.: Central nervous system involvement by leukemia in children. I. Relationship to systemic leukemia and description of clinical and laboratory manifestations. Blood25: 1, 1965.
4.
Nies, B., Bodey, G., Thomas, L. et al.: The persistence of extra-medullary leukemic infiltrates during bone marrow remission of acute leukemia. Blood26: 133, 1965.
5.
Shaw, R., Moore, E., Freireich, E. and Thomas, L.: Meningeal leukemia, a syndrome resulting from increased intracranial pressure in patients with acute leukemia. Neurology10: 823, 1960.
6.
Skeel, R., Yankee, R. and Henderson, E.: Meningeal leukemia; two simple methods for rapid detection of malignant cells in spinal fluid. JAMA205: 863, 1968.
7.
D'Angio, G., Evans, A. and Mitus, A.: Roentgen therapy of certain complications of acute leukemia in childhood. Am. J. Roentgenol.82: 541, 1959.
8.
Hyman, C., Bogle, J.Brubaker, C. et al.: Central nervous system involvement in children. II. Therapy with intrathecal methotrexate. Blood25: 13, 1965.
9.
Evans, A., D'Angio, G. and Mitus, A.: Central nervous system complications of children with acute leukemia; an evaluation of treatment methods. J. Pediatr.64: 94, 1964.
10.
Sullivan, M. , Vietti, T., Fernbach, D. et al.: Clinical investigations in the treatment of meningeal leukemia; radiation therapy regimens vs. conventional intrathecal methotrexate. Blood34: 301, 1969.
11.
Rosner, F., Lee, S., Kagan, M. and Morrision, A.: Intrathecal methotrexate. Lancet1: 249, 1970.
12.
Baum, E., Koch, H., Corby, D. and Plunket, D.: Intrathecal methotrexate. Lancet1: 649, 1971.
13.
Saiki, J., Thompson, S., Smith, F. and Atkinson, R.: Paraplegia following intrathecal chemotherapy. Cancer29: 370, 1972.
14.
Back, E.: Death after intrathecal methotrexate. Lancet2: 1005, 1969.
15.
Wang, J. and Pratt, C.: Intrathecal arabinosyl cytosine in meningeal leukemia. Cancer25: 531, 1970.
16.
Halikowski, B., Cyklis, R., Armata, J. et al.: Cytosine arabinoside administered intrathecally in cerebromeningeal leukemia. Acta Paediatr. Scand.59: 164, 1970.
17.
Geils, G., Scott, C., Baugh, C. and Butterworth, C.: Treatment of meningeal leukemia with pyrimethamine. Blood38: 131, 1971.
18.
Nies, B., Thomas, L. and Freireich, E.: Meningeal leukemia: a follow-up study. Cancer18: 546. 1965.
19.
Aur, R., Simone, J.Hustu, H. et al.: Central nervous system therapy and combination chemotherapy of childhood lymphocytic leukemia. Blood37: 272, 1971.
20.
Thomas, L.: Pathology of leukemia in the brain and meninges. Cancer Res.25: 1555, 1965.
21.
Mathé, G., Schwartzberg, L., Mery, A. et al.: Extensive histological and cytological survey of patients with acute leukemia in "complete remission." Br. Mod. J.1: 640, 1966.
22.
Melhom, D., Gross, S., Fisher, B. and Newman, A.: Studies on the use of "prophylactic" intrathecal amethopterin in childhood leukemia. Blood36: 55, 1970.
23.
Rieselbach, R., Di Chiro, G., Freireich, E. and Rall, D.: Subarachnoid distribution of drugs after lumbar injection. N. Eng. J. Med.267: 1272, 1972 .
24.
Aur, R., Simone, J., Hustu, H.O. and Verzosa, M.: A comparative study of central nervous system irradiation and intensive chemotherapy early in remission of childhood acute lymphocytic leukemia. Cancer29: 381, 1972.