Five instances of antihistamine toxicity in children, one resulting in death, are reported here. Three cases were caused by accidental ingestions and two were caused by physician-prescribed overdoses. Initial symptoms and clinical course are far from constant. Control of toxic central-nervous-system symptoms by sedation or anticonvulsive drugs is a cardinal part of treatment. Stimulants or even mechanical respiratory devices may be needed later for management of postconvulsive depressive states.
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