This paper briefly discusses the action of the ototoxic antibiotics on the human labyrinth, reviews their pharmacologic properties and summarizes their clinical indications.
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References
1.
Axline, S.G. and Simon, H.J.: Pediatric hazard of drugs in solutions, convenient for administration to adults. Letter to the Editor. Pediatrics33: 999, 1964.
2.
Brunner, R. and Machek, G.: Die Antibiotica, II Die Mittleren Antibiotica. Nuernberg , Verlag Hans Carl, 1965 , p. 218.
3.
Conway, N.: Streptomycin in pregnancy—effect on foetal ear. Brit. Med. J. p. 260, July 31, 1965.
4.
Davis, H.: Handbook of Physiology, Section 1 Neurophysiology. Amer. Phys. Soc.Washington, D. C., 1959, p. 576.
5.
Davis, H., Deatherage, B.H., Rosenblut, B., Fernandez, C., Kimura, R. and Smith, C.A.: Modincation of cochlear potentials produced by streptomycin poisoning and by extensive venous obstruction. Laryngoscope68: 596, 1958.
6.
Eichenwald, H.: N. Y. Acad. Sci. Conference on Kanamycin, December 1965. In press.
7.
Erlanson, P. and Lundgren, A.: Ototoxic side effects following treatment with streptomycin, dihydrostreptomycin and kanamycin. Acta Medica Scand. Vol. 176, fasc. 2, 1964.
Finegold, S.M. , Winfield, M.H., Aronsohn , R.B., Hewitt, W.L. and Guze, L.B.: Clinical experience with kanamycin. Ann. N. Y. Acad. Sci.76: 319, 1958.
10.
Fuller, A.: Ototoxicity of neomycin aerosol. Lancet1026, May 7, 1960.
11.
Goodman, L.S. and Gilman, A.: The Pharmacological Basis of Therapeutics . 3rd Edition. New York, Macmillan, 1965.
12.
Greenberg, L.H. and Momary, H.: Audiotoxicity and nephrotoxicity due to orally administered neomycin. JAMA194: 827, 1965 .
13.
Haapanen, J.H. : Auditory toxicity of kanamycin in tuberculous patients. Ann. Med. Intern. Fenn.52: Suppl. 42, 1963.
14.
Hawkins, J.E. , Jr. and Lurie, M.M.: The ototoxicity of streptomycin . Ann. Otol. Rhinol. and Laryngol.61: 789, 1952.
15.
Hawkins, J.E. and Lurie, M.H.: The ototoxicity of dihydrostreptomycin and neomycin in the cat. Ann. Otol. Rhinol. and Laryngol.62: 1128, 1953.
16.
Hawkins, J.E. , Jr.: Antibiotics and the inner ear. Trans. Amer. Acad. Ophthalm. Otol.63: 206, 1959.
17.
Hawkins, J.E. , Rahway, N.J. and Lurie, M.H.: The ototoxicity of dihydrostreptomycin and neomycin in the cat. Ann. Otol.62: 1127, 1953 .
18.
Hughes, D.E. and Chou, J.T.Y.: Life sci.2: 107, 1963.
19.
King, J.T.: Severe deafness in an infant following oral administration of neomycin . J. Med. Assoc. Georgia51: 530, 1962.
20.
Kohonen, A. : Effect of some ototoxic drugs upon the pattern and innervation of cochlear sensory cells in the guinea pig. Act. Otolaryng. Suppl.208.
21.
Koide, Y.: Introductory studies of the chemical physiology of the labyrinth. Acta Med. Biol.6: 1, 1958.
22.
Kossowski, S., Gieldanowski, J. and Ziemski, Z.: Experimental studies on the ototoxicity of certain antibiotics. Archivum Immunologiae et Therapiae Experimentalis12: 402, 1964.
23.
Krahl, P.: Ototoxische Antibiotica in Ohrentropfen, ihre Vorzüge und Gefahren . Arch. Ohr. Nas. Kehlkopfheilk182: 591, 1963 .
24.
Kunin, C.M. , Charlmers, T.G., Levy , C.M., Sebastyen, S.C., Liever, C.S. and Finland, M.: Absorption of orally administered neomycin and kanamycin, with special reference to patients with severe hepatic and renal disease. Antibiot. Ann, p. 489, 1959-60.
25.
Kunin, C.M. and Finland, M.: Restrictions imposed on antibiotic therapy by renal failure. Arch. Int. Med.104: 1030, 1959 .
26.
Last, P.M. and Sherlock, S.: Systemic absorption of orally administered neomycin in liver disease . New Eng. J. Med.262: 385, 1960.
27.
Leach, W.: Ototoxicity of neomycin and other antibiotics. J. Laryng.76: 774, 1962.
28.
Marsden, H.B. and Hyde, W.A.: Colistin methane sulphonate in childhood infections. Lancet, Oct. 13, 1963, p. 740.
29.
Massenat-Deroche, B.: La Framycetine—un Nouvel Antibiotique . Thesis for M.D. (Paris) 1955. Unpublished.
30.
Muesebeck, K.: Zum Wirkungsmechanismus der Streptomycin-Vergiftung des Ohres. Arch. Ohr. Nas. und Kehlkopf Krankheiten182: 583, 1963.
31.
Naftalin, L. and Harrison, M.S.: Circulation of labyrinthine fluids. J. Laryng.72: 118, 1958.
32.
Ory, E.M.: N. Y. Acad. Sci. Conference on Kanamycin, December 1965. In press.
33.
Pulaski, E.J. and Tubbs, R.S.: Inhibitory effects of kanamycin and diffusion into various body fluids. Antibiot. Med.6: 589, 1959.
34.
Report of the Committee on the Control of Infectious Diseases. Table 2, p. 130, Amer. Acad. Pediat., 14th Edition, 1964.
35.
Riskaer, N. , Christensen, E., Petersen , P.V. and Weidman, H.: The ototoxicity of neomycin; experimental investigations. Acta Otolaryng. 46: 137, 1956.
36.
Robinson, G.C. and Cambon, K.G.: Hearing loss in infants of tuberculous mothers treated with streptomycin during pregnancy. New Eng. J. Med.271: 949, 1964.
37.
Sanford, J. : N. Y. Acad. Sci. Conference on Kanamycin, December 1965. In press.
38.
Shirkey, H.C. : Pediatric Therapy. 2nd ed. St. Louis, C. V. Mosby Company , 1966, p. 315.
39.
Simon, H.J. : N. Y. Acad. Sci. Conference on Kanamycin, December 1965. In press.
40.
Spoendlin, H. and Balogh, K., Jr.: Licht- und Elektronenmikroskopische Darstellung von Dehydrogenasen in der Schnecke nach Intravitaler Inkubation . Pract. Otorhinolaryng. (Basel) 26: 159, 1964.
41.
Stewart, I.F.: Proceedings of the Canadian Otolaryngological Society, Vol. 20, 1966. In press.
42.
Tisch, D.E. , Huftalen, J.B. and Dickinson , H.L.: Pharmacological studies with kanamycin. Ann. N. Y. Acad. Sci.76, Art. 2, 1958.
43.
Tyberghein, J. : Influence of some Streptomyces antiobiotics on the cochlear microphonics in the guinea pig. Acta Otolaryngol. , Suppl. 171, 1962.
44.
Voldrich, L. : The kinetics of streptomycin, kanamycin and neomycin in the inner ear. Acta Otolaryng. 60: 242, 1965.
45.
Vosteen, K.H. : The histochemistry of the enzymes of oxygen metabolism in the inner ear. Laryngoscope70: 351, 1960.
46.
Vosteen, K.H. : Elektronenmicroskopische Untersuchungen ueber die Verteilung von Glycogen im Ductus Cochlearis bei Meerschweinchen. Pract. Otorhinolaryng.26: 400, 1964.
47.
Vosteen, K.H. : Neue Aspecte zur Biologie und Pathologie des Innenohres. Arch. Ohr. Nas. Kehlkopfheilk178: 1, 1961.
48.
Vosteen, K.H. : Energy production in Corti's organ. Act. Otolaryng. (Stockh.) Suppl. 163: 54, 1961.
49.
Wallace, J.F. , Smith, R.H. and Petersdorf , R.G.: Oral administration of vancomycin in the treatment of staphylococcal enteritis. New Eng. J. Med.272: 1014, 1965.
50.
Welch, H., Wright, W.W., Weinstein, H.I. and Staffer, A.W.: In vitro and pharmacological studies with kanamycin. Ann. N. Y. Acad. Sci.76: 66, 1958.