Linoleic Acid —

Evans, H.M. and G.O. Burr : A new dietary deficiency with highly purified diets. Proc. Soc. Exp. Biol. Med. 24: 740, 1927.

Evans, H.M. and G.O. Burr : New dietary deficiency with highly purified diets. II. Supplementary requirements of diet of pure casein, sucrose and salt. Proc. Soc. Exp. Biol. Med. 25: 41, 1927.

Evans, H.M. and G.O. Burr : A new dietary deficiency with highly purified diets. III. The beneficial effect of fat in the diet. Proc. Soc. Exp. Biol. Med. 25: 390, 1928.

McAmis, A.J. , W.E. Anderson and L.B. Mendel : Growth of rats on fat-free diets. J. Biol. Chem. 82: 247, 1929.

Burr, G.O. : Significance of the essential fatty acids. Fed. Proc. 1: 224, 1942.

White, E.A. , J.R. Foy and L.R. Cerecedo : Essential fatty acid deficiency in mouse. Proc. Soc. Exp. Biol. Med. 54: 301, 1943.

Reiser, R. : The metabolism of polyunsaturated fatty acids in growing chicks. J. Nutrition 42: 325, 1950.

Witz, W.M. and W.M. Beeson : The physiological effect of a fat-deficient diet on the pig. J. Animal Sci. 10: 112, 1951.

Cunningham, H.M. and J.K. Loosli : Effect of fat-free diet on lambs and goats . J. Animal Sci. 13: 265, 1954.

Lambert, M.R. , N.H. Jacobson , R.S. Allen and J.H. Zaletel : Lipid deficiency in the calf. J. Nutrition 52: 259, 1954.

Reid, M.E. : Production and counteraction of a fatty acid deficiency in the guinea pig . Proc. Soc. Exp. Biol. Med. 86: 708, 1954.

Dam, H. and F. Christensen : Alimentary production of gallstones in hamsters. Acta Pathol. Microbiol. Scand. 30: 236, 1952.

Hansen, A.E. and H.F. Wiese : Fat in the diet in relation to nutrition in the dog. I. Characteristic appearance and gross changes of animals fed diets with and without fat. Texas Rep. Biol. Med. 9: 491, 1951.

Greenberg, L.D. and H.D. Moon : Alterations in the blood fatty acids in single and combined deficiencies of essential fatty acids and B6 in monkeys. Arch. Biochem. & Biophys. 94: 405, 1961.

Burr, G.O. and M.M. Burr : Nature and role of the fatty acids essential in nutrition. J. Biol. Chem. 86: 587, 1930.

Burr, G.O. and A.J. Beber : Metabolism studies with rats suffering from fat deficiency. Proc. Soc. Exp. Biol. Med. 31: 911, 1934.

Adam, D.J.D. , A.E. Hansen and H.F. Wiese : Essential fatty acids in infant nutrition. II. Effect of linoleic acid on caloric intake. J. Nutrition 66: 555, 1958.

Hansen, A.E. , M.E. Haggard , A.N. Boelsche , D.J.D. Adam and H.F. Wiese : Essential fatty acids in infant nutrition. III. Clinical manifestations of linoleic acid deficiency. J. Nutrition 66: 565, 1958.

Hansen, A.E. , H.F. Wiese , A.N. Boelsche , M.E. Haggard , D.J.D. Adam and H. Davis : Role of linoleic acid in infant nutrition Pediatrics 31: 171, 1963.

Panos, T.C. , J.C. Finerty and R.L. Wall : Increased metabolism in fat deficiency: relation to dietary fat. Proc. Soc. Exp. Biol. Med. 93: 581, 1956.

Klein, P.D. and R.M. Johnston : Phosphorus metabolism in unsaturated fatty acid deficient rats. J. Biol. Chem. 211: 103, 1954 .

Widmer, C. and R.T. Holman : Polyethenoid fatty acid metabolism. II. Deposition of polyunsaturated fatty acids in fat-deficient rats upon single fatty acid supplementation. Arch. Biochem. 25: 1, 1950.

Lehninger, A.L. : The enzymic and morphologic organization of the mitochondria. Pediatrics 26: 466, 1960.

Mukherjee, S. and R.B. Alfin-Slater : The effect of the nature of dietary fat on synthesis of cholesterol from acetate-1-C14 in rat liver slices. Arch. Biochem. & Biophys. 73: 359, 1958.

Holman, R.L. , H.C. McGill , Jr., J.P. Strong and J.C. Geer : Arteriosclerosis—the lesion. Am. J. Clin. Nutrition 8: 85, 1960.

Kube, N. and Solowjew : Uber die lipoidablagerung in ser aorta von kindern im fruhen Sauglingsalter . Frankfurt Z. Path. 40: 302, 1930.

Holman, R.L. : Atherosclerosis—A pediatric nutrition problem? Am. J. Clin. Nutrition 9: 565, 1961.

James, A.T. and A.J.P. Martin : Gas-liquid partition chromatography: The separation and micro-estimation of volatile fatty acids from formic acid to dodecanoic acid. Biochem. J. 50: 679, 1952.

James, A.T. and A.J.P. Martin : Gas-liquid partition chromatography. A technique of the analysis of volatile minerals. Analyst 77: 915, 1952.

Orr, C.H. and J.E. Callen : Separation of polyunsaturated fatty acid methyl esters by gas chromatography . J. Am. Chem. Soc. 80: 249, 1958.

Lipsky, S.R. , R.A. Landowne and M.R. Godet : Effects of varying the chemical composition of the stationary liquid on the resolution of the long chain saturated and unsaturated fatty acid esters by gas-liquid chromatography. Biochem. and Biochem. and Biophy. Acta 31: 336, 1959.

Farquhar, J.W. , W. Insull , Jr., P. Rosen , W. Stoffel and E.H. Ahrens , Jr.: The analysis of fatty acid mixtures by gas-liquid chromatography. Nutrition Reviews (Supplement) 17, No. 8, Pt. II, 1959.

Craig, B.M. and N.L. Murty : The separation of saturated and unsaturated fatty acid esters by gas-liquid chromatography. Can. J. Chem. 36: 1297, 1958.

Official Methods of Analysis of the Association of Official Agricultural Chemists. 9th Ed. No. 15.029, p. 190, 1960.

Official Methods of Analysis of the Association of Official Agricultural Chemists. 9th Ed. No. 22.035, p. 287, 1960.

Deuel, H.J. , Jr., S.M. Greenberg , L. Anisfeld and D. Melnick : The effect of fat level of the diet on general nutrition. VIII. The essential fatty acid content of margarines, shortenings, butters and cottonseed oil as determined by a new biological assay method . J. Nutrition 45: 535, 1951.

Peifer, J.J. and R.T. Holman : Effect of saturated fat upon essential fatty acid metabolism of the rat. J. Nutrition 68: 155, 1959.

Hansen, A.E. : High and low dietary protein in fat deficiency states as influenced by the caloric intake. Research Supplement to 39th Annual Report, National Livestock & Meat Board, Chicago, Illinois , 1961-1962.

Caster, W.O. and R.T. Holman : Statistical study of the relationship between dietary linoleate and the fatty acids of heart and blood lipids. J. Nutrition 73: 337, 1961.

Combes, M.A. , E.L. Pratt and H.F. Wiese : Essential fatty acids in premature infant feeding. Pediatrics 30: 136, 1962.

Wiese, H.F. , A.E. Hansen and D.J.D. Adam : Essential fatty acids in infant nutrition. I. Linoleic acid requirement in terms of serum di-, tri-, and tetraenoic acid levels. J. Nutrition 66: 345, 1958.

Holman, R.T. : The ratio of trienoic/tetraenoic acids in tissue lipids as a measure of essential fatty acid requirement. J. Nutrition 70: 405, 1960.

Committee on Nutrition, American Academy of Pediatrics : Composition of milks. Pediatrics 26: 1045, 1960.

Greenberg, S.M. , C.E. Calbert , E.E. Savage and H.J. Deuel , Jr.: The effect of fat level of the diet on general nutrition. VI. The interrelation of linoleate and linolenate in supplying the essential fatty acid requirement in the rat. J. Nutrition 41: 473, 1950.