Effect of Terbutaline Combined With Xiao’er Kechuanling on Efficacy and Airway Remodeling Indices in Children With Asthma

Abstract

This study evaluated the efficacy of terbutaline combined with Xiao’er Kechuanling in treating pediatric asthma and its effect on airway remodeling indicators. Eighty children were randomized into control (n = 40, terbutaline) and observation (n = 40, terbutaline + Xiao’er Kechuanling) groups, both receiving routine therapy. Clinical efficacy, adverse reactions, symptom relief time, lung function, and airway remodeling indices were compared. The observation group showed higher efficacy (χ² = 4.909, P = .027), higher FVC, FEV1, and FEV1/FVC (t = 2.161, 6.648, 2.980, all P < .05), shorter relief times for dyspnea, wheezing, and cough (t = 9.402, 3.276, 7.133, 4.481, all P < .05), and lower airway remodeling indices (t = 7.715, 5.829, 3.484, 5.023, all P < .001). Adverse reactions showed no difference (χ² = 0.103, P = .749). Terbutaline plus Xiao’er Kechuanling improved efficacy, lung function, and airway remodeling, accelerated symptom relief, and was well tolerated.