Risk Factors and Changes of Serum IL-6,IL-17,and TGF-β in Children With Acute Myocarditis

Abstract

The study examines variations of serum interleukin (IL)-6, IL-17, and transforming growth factor-β (TGF-β) in pediatric viral myocarditis. One hundred and twenty children diagnosed with acute viral myocarditis were divided into survival (n = 60) and death (n = 60) groups according to their prognosis. Troponin I, serum IL-6, IL-17, TGF-β, creatine kinase isoenzyme MB, and brain natriuretic peptide levels were significantly increased on admission and gradually increased during 1 week of immune monitoring, of which TGF-β and IL-6 peaked in the second week and IL-17 peaked in the fourth week. The above-mentioned indices were significantly lower in the survival group than those in the death group (P < .05). The survival group exhibited significantly higher left ventricular ejection fraction (LVEF) (P < .05) and significantly lower brain natriuretic peptide (BNP) level (t = −0.408, P = .72) than the death group. The serum levels of IL-6, IL-17, and TGF-β were significantly increased in children with acute viral myocarditis, and the LVEF was the main influencing factor leading to poor prognosis.