This study aimed to investigate the reference values for serum uric acid (SUA) levels and their association with overweight/obese in children. We conducted a retrospective analysis of 8522 participants, including 6227 normal weight children, aged 2 to 18 years in China. Among normal children, SUA levels increased with age, showing significant sex differences in children over 10 years. Age-specific and sex-specific 95% reference intervals for SUA levels were established. Furthermore, we observed that the percentage of overweight/obesity significantly increased as SUA quartiles rose. Elevated SUA levels were associated with a high odds ratio (OR) for overweight/obesity (OR = 4.45, 95% confidence interval = 3.33, 5.93). We propose that the 97.5th percentile is a suitable value for defining elevated SUA levels, and there is a positive correlation between SUA levels and the presence of overweight or obesity.
LiCHsiehMCChangSJ.Metabolic syndrome, diabetes, and hyperuricemia. Curr Opin Rheumatol. 2013;25:210-216.
4.
YuTYJeeJHBaeJC, et al. Serum uric acid: a strong and independent predictor of metabolic syndrome after adjusting for body composition. Metabolism. 2016;65(4):432-440.
5.
Rivera-ParedezBMacías-KaufferLFernandez-LopezJC, et al. Influence of genetic and non-genetic risk factors for serum uric acid levels and hyperuricemia in Mexicans. Nutrients. 2019;11:1336.
ZhuCCuiRGaoM, et al. The associations of serum uric acid with obesity-related acanthosis nigricans and related metabolic indices. Int J Endocrinol. 2017;2017:5438157.
8.
de MirandaJAAlmeidaGGMartinsRI, et al. The role of uric acid in the insulin resistance in children and adolescents with obesity. Rev Paul Pediatr. 2015;33(4):431-436.
9.
MonastaLLobsteinTColeTJVignerovaJCattaneoA.Defining overweight and obesity in pre-school children:IOTF reference or WHO standard?Obes Rev. 2011;12(4):295-300.
10.
KubotaM.Hyperuricemia in children and adolescents: present knowledge and future directions. J Nutr Metab. 2019;2019:3480718.
11.
LohTPMetzMP.Trends and physiology of common serum biochemistries in children aged 0-18 years. Pathology. 2015;47(5):452-461.
12.
HsiaSHChouIJKuoCF, et al. Survival impact of serum uric acid levels in children and adolescents. Rheumatol Int. 2013;33(11):2797-2802.
13.
BeydounMACanasJAFanelli-KuczmarskiMTTajuddinSMEvansMKZondermanAB.Genetic risk scores, sex and dietary factors interact to alter serum uric acid trajectory among African- American urban adults. Br J Nutr. 2017;117(5):686-697.
14.
WangYCharcharFJ.Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys. Sci Rep. 2021;11:17323.
15.
LiNZhangSLiW, et al. Prevalence of hyperuricemia and its related risk factors among preschool children from China. Sci Rep. 2017;7:9448.
16.
PanSHeCHMaYT, et al. Serum uric acid levels are associated with high blood pressure in Chinese children and adolescents aged 10-15 years. J Hypertens. 2014;32(5):998-1003; discussion 1004.
17.
FordESLiCCookSChoiHK.Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation. 2007;115:2526-2532.
18.
LiuHTWenBZZhangYHZhangYQWangP.Detection rate and related factors of hyperuricemia in 808 children aged from 10 to 11 years. Chin J Health Manage. 2016;10:463-466.
19.
OyamaCTakahashiTOyamadaM, et al. Serum uric acid as an obesity-related indicator in early adolescence. Tohoku J Exp Med. 2006;209(3):257-262.
20.
ChoSMLeeSGKimHSKimJH.Establishing pediatric reference intervals for 13 biochemical analytes derived from normal subjects in a pediatric endocrinology clinic in Korea. Clin Biochem. 2014;47(18):268-271.
21.
LiuJDaiYLeeY, et al. Pediatric reference intervals of liver and renal function tests from birth to adolescence in Chinese children as performed on the Olympus AU5400. Clin Chim Acta. 2019;490:142-146.
22.
CliffordSMBunkerAMJacobsenJRRobertsWL.Age and gender specific pediatric reference intervals for aldolase, amylase, ceruloplasmin, creatine kinase, pancreatic amylase, prealbumin, and uric acid. Clin Chim Acta. 2011;412:788-790.
23.
ZhongXHDingJZhouJH, et al. A multicenter study of reference intervals for 15 laboratory parameters in Chinese children. Zhonghua Er Ke Za Zhi. 2018;56:835-845.
24.
Moulin-MaresSRAZaniqueliDOliosaPRAlvimROBottoniJPMillJG. Uric acid reference values: report on 1750 healthy Brazilian children and adolescents. Pediatr Res. 2021;89(7):1855-1860.
25.
KawasakiYHosoyaMYasumuraS, et al. The basic data for residents aged 15 years of younger who received a comprehensive health check in 2011-2012 as a part of the Fukushima health management survey after the great east Japan earthquake. Fukushima J Med Sci. 2015;61:101-110.
26.
BusslerSPenkeMFlemmingG, et al. Novel insights in the metabolic syndrome in childhood and adolescence. Horm Res Paediatr. 2017;88(3-4):181-193.
27.
DeBoerMDDongLGurkaMJ.Racial/ethnic and sex differences in the relationship between uric acid and metabolic syndrome in adolescents: an analysis of National Health and Nutrition Survey 1999-2006. Metabolism. 2012;61(4):554-561.
28.
ZhangCLiLZhangYZengC.Recent advances in fructose intake and risk of hyperuricemia. Biomed Pharmacother. 2020;131:110795.
29.
Di BonitoPValerioGLicenziatiMR, et al. Uric acid versus metabolic syndrome as markers of fatty liver disease in young people with overweight/obesity. Diabetes Metab Res Rev. 2022;38(7):e3559.
