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Abstract

This investigation aimed to assess the safety and efficacy of NeoLight’s Skylife phototherapy device for the treatment of hyperbilirubinemia. A prospective, two-arm, randomized, unblinded controlled investigation compared total serum bilirubin (TSB) levels at baseline and discharge for a new phototherapy device (Skylife) with an existing phototherapy treatment in newborn infants. The repeated-measures analysis of variance (RM-ANOVA) indicated a significant main effect for the treatment condition, F(1, 54) = 4.041, P = .049. Post hoc findings showed that the Skylife group had significantly lower TSB levels following treatment (n = 28, Mean = 11.36, SD = 1.69) compared with the standard of care group (n = 28, Mean = 12.37, SD = 2.08), t(54) = 2.01, P = .049). The Skylife phototherapy device was as effective as the currently used therapy, with a shift toward a more rapid decline in bilirubin levels. Using this device may potentially decrease the length of therapy and hospitalization.Clinical Trial Registration Comparison of Phototherapy Using Neolight Skylife Versus Standardized Phototherapy for Hyperbilirubinemia in Newborns is registered at clinicaltrials.gov as NCT03599258

Keywords

infant newborn bilirubin hyperbilirubinemia phototherapy

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References

Ourworldindata.org. How many people die and how many are born each year? Accessed May 14, 2021. https://ourworldindata.org/births-and-deaths.

Siddappa

Prekker

Slusher

. Improving effectiveness of phototherapy in an academic center: a quality improvement project. Glob Pediatr Health. 2020;7:2333794X20969275. doi:10.1177/2333794X20969275

Maisels

McDonagh

. Phototherapy for neonatal jaundice. N Engl J Med. 2008;358(9):920-928. doi:10.1056/NEJMct0708376

Johnson

Bhutani

. The clinical syndrome of bilirubin-induced neurologic dysfunction. Semin Perinatol. 2011;35(3):101-113. doi:10.1053/j.semperi.2011.02.003

Stokowski

. Fundamentals of phototherapy for neonatal jaundice. Adv Neonatal Care. 2011;11(5 Suppl.):s10-s21. doi:10.1097/ANC.0b013e31822ee62c

Sachdeva

Murki

Oleti

Kandraju

. Intermittent versus continuous phototherapy for the treatment of neonatal non-hemolytic moderate hyperbilirubinemia in infants more than 34 weeks of gestational age: a randomized controlled trial. Eur J Pediatr. 2015;174(2):177-181. doi:10.1007/s00431-014-2373-8

American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114(1):297-316. doi:10.1542/peds.114.1.297

Bhutani

, Committee on F, Newborn American Academy of P. Phototherapy to prevent severe neonatal hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2011;128(4):e1046. doi:10.1542/peds.2011-1494

Hansen

TWR

Maisels

Ebbesen

, et al. Sixty years of phototherapy for neonatal jaundice—from serendipitous observation to standardized treatment and rescue for millions. J Perinatol. 2020;40(2):180-193. doi:10.1038/s41372-019-0439-1

10.

Kumar

Murki

Malik

, et al. Light-emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: a multi-center randomized controlled trial. Indian Pediatr. 2010;47(2):131-137. doi:10.1007/s13312-010-0020-7

11.

Mohammadizadeh

Eliadarani

Badiei

. Is the light-emitting diode a better light source than fluorescent tube for phototherapy of neonatal jaundice in preterm infants. Adv Biomed Res. 2012;1:51. doi:10.4103/2277-9175.100158

A Randomized Trial Comparing NeoLight Skylife and Blanket Phototherapy in Newborn Indirect Hyperbilirubinemia

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