A Case Report of Macrophage Activation Syndrome Complicating Multisystem Inflammatory Syndrome in Children Associated With COVID-19: A Diagnostic Challenge

Riphagen S Gomez X Gonzalez-Martinez C Wilkinson N Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020;395:1607-1608.

Nagata S. Causes of Kawasaki disease—from past to present. Front Pediatr. 2019;7:18.

Chang LY Lu CY Shao PL , et al. Viral infections associated with Kawasaki disease. J Formos Med Assoc. 2014;113:148-154.

Nakra NA Blumberg DA Herrera-Guerra A Lakshminrusimha S. Multi-system inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection: review of clinical presentation, hypothetical pathogenesis, and proposed management. Children (Basel). 2020;7:69.

Godfred-Cato S Bryant B Leung J , et al. COVID-19–associated multisystem inflammatory syndrome in children—United States, March-July 2020. MMWR Morb Mortality Wkly Rep. 2020;69:1074-1080.

García-Pavón S Yamazaki-Nakashimada MA Báez M Borjas-Aguilar KL Murata C. Kawasaki disease complicated with macrophage activation syndrome: a systematic review. J Pediatr Hematol Oncol. 2017;39:445-451.

Henderson LA Canna SW Friedman KG , et al. American College of Rheumatology clinical guidance for pediatric patients with multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 and hyperinflammation in COVID-19. Version 2. Arthritis Rheumatol. 2021;73:e13-e29.

Lin CI Yu HH Lee JH , et al. Clinical analysis of macrophage activation syndrome in pediatric patients with autoimmune diseases. Clin Rheumatol. 2012;31:1223-1230.

Coffernils M Soupart A Pradier O Feremans W Nève P Decaux G. Hyperferritinemia in adult onset Still’s disease and the hemophagocytic syndrome. J Rheumatol. 1992;19:1425-1427.

Wang W Gong F Zhu W Fu S Zhang Q. Macrophage activation syndrome in Kawasaki disease: more common than we thought? Semin Arthritis Rheum. 2015;44:405-410.

Loomba RS Villarreal EG Flores S. COVID-19 and hyperinflammatory syndrome in children: Kawasaki disease with macrophage activation syndrome in disguise? Cureus. 2020;12:e9515.

Nigrovic LE Nigrovic PA Harper MB Chiang VW. Extreme thrombocytosis predicts Kawasaki disease in infants. Clin Pediatr (Phila). 2006;45:446-452.

Freeman AF Shulman ST. Refractory Kawasaki disease. Pediatr Infect Dis J. 2004;23:463-464.

American Academy of Pediatrics. Kawasaki disease. In: Kimberlin DW Brady MT Jackson MA Long SS , eds. Red Book: 2018 Report of the Committee on Infectious Diseases. 31st ed. American Academy of Pediatrics; 2018:490.