Is There a “Direct” Answer: Should We Perform Exchange Transfusion for Neonatal Predominantly Conjugated Hyperbilirubinemia?

Zonneveld R Van Der Meer-Kapelle L Sylva M Brand A Zijlstra M Schonewille H . Severe fetal hemolysis and cholestasis due to high-titer maternal IgG anti-A antibodies. Pediatrics. 2019;143:e20182859. doi:10.1542/peds.2018-2859

Kaplan M Wong RJ Stevenson DK . Hemolysis and glucose-6-phosphate dehydrogenase deficiency-related neonatal hyperbilirubinemia. Neonatology. 2018;114:223-225. doi:10.1159/000489820

Kordes U Richter A Santer R , et al. Neonatal cholestasis and glucose-6-P-dehydrogenase deficiency. Pediatr Blood Cancer. 2010;54:758-760. doi:10.1002/pbc.22390

Sivan Y Merlob P Nutman J Reisner SH . Direct hyperbilirubinemia complicating ABO hemolytic disease of the newborn. Clin Pediatr (Phila). 1983;22:537-538. doi:10.1177/000992288302200802

Smits-Wintjens VEHJ Rath MEA Lindenburg ITM , et al. Cholestasis in neonates with red cell alloimmune hemolytic disease: incidence, risk factors and outcome. Neonatology. 2012;101:306-310. doi:10.1159/000335333

McAdams RM Dotzler SA Winter LW Kerecman JD . Severe hemolytic disease of the newborn from anti-e. J Perinatol. 2008;28:230-232. doi:10.1038/sj.jp.7211897

Muraca M Fevery J Blanckaert N . Relationships between serum bilirubins and production and conjugation of bilirubin. Studies in Gilbert’s syndrome, Crigler-Najjar disease, hemolytic disorders, and rat models. Gastroenterology. 1987;92:309-317. doi:10.1016/0016-5085(87)90123-5

Kaplan M Muraca M Hammerman C , et al. Imbalance between production and conjugation of bilirubin: a fundamental concept in the mechanism of neonatal jaundice. Pediatrics. 2002;110:e47. doi:10.1542/peds.110.4.e47

Raju TN Javed DI . Fetal intrahepatic cholestasis secondary to BO hemolytic disease. J Natl Med Assoc. 1981;73:747-749.

Corchia C Balata A Meloni GF Meloni T . Favism in a female newborn infant whose mother ingested fava beans before delivery. J Pediatr. 1995;127:807-808. doi:10.1016/s0022-3476(95)70178-8

Suria AA Nurasyikin Y Adibah AG Cheah FC Leong CF . ABO incompatibility and glucose-6-phosphate dehydrogenase deficiency presenting as Hydrops foetalis. Clin Ter. 2014;165:151-154. doi:10.7417/CT.2014.1714

Molad M Waisman D Rotschild A , et al. Nonimmune hydrops fetalis caused by G6PD deficiency hemolytic crisis and congenital dyserythropoietic anemia. J Perinatol. 2013;33:490-491. doi:10.1038/jp.2012.116

Doxiadis SA Valaes T . The clinical picture of glucose 6-phosphate dehydrogenase deficiency in early infancy. Arch Dis Child. 1964;39:545-553. doi:10.1136/adc.39.208.545

American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114:297-316. doi:10.1542/peds.114.1.297

National Institute for Health and Care Excellence. Jaundice in newborn babies under 28 days. Published May 19, 2010. Accessed May 13, 2020. https://www.nice.org.uk/guidance/cg98/chapter/Recommendations

Kaplan M Wong RJ Sibley E Stevenson DK . Neonatal jaundice and liver diseases. In: Martin RJ Fanaroff AA Walsh MC , eds. Fanaroff and Martin’s Neonatal-Perinatal Medicine. 11th ed. Elsevier; 2019:1443-1496.

Maisels M Watchko J . Jaundice. In: MacDonald M Seshia MMK , eds. Avery’s Neonatology: Pathophysiology & Management of the Newborn. Wolters Kluwer; 2016: 587-645.

Gleason CA Juul SE . Neonatal indirect hyperbilirubinemia and kernicterus. In: Avery’s Diseases of the Newborn. 10th ed. Elsevier; 2017:1988-1218.

Watchko JF . Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns. Neuromolecular Med. 2006;8:513-529. doi:10.1385/NMM:8:4:513

Polácek K . Risk of kernicterus in newborn infants with a high level of conjugated bilirubin. Acta Paediatr Scand. 1966;55:401-404. doi:10.1111/j.1651-2227.1966.tb08812.x

Priolisi A . Does conjugated bilirubin displace unconjugated bilirubin from albumin. Arch Dis Child. 1976;51:990-991. doi:10.1136/adc.51.12.990-b

Grobler JM Mercer MJ . Kernicterus associated with elevated predominantly direct-reacting bilirubin. S Afr Med J. 1997;87:1146.

Clark CF Torii S Hamamoto Y Kaito H . The “bronze baby” syndrome: postmortem data. J Pediatr. 1976;88:461-464. doi:10.1016/s0022-3476(76)80268-5

Bertini G Dani C Fonda C Zorzi C Rubaltelli FF . Bronze baby syndrome and the risk of kernicterus. Acta Paediatr. 2005;94:968-971. doi:10.1111/j.1651-2227.2005.tb02020.x

Steiner LA Bizzarro MJ Ehrenkranz RA Gallagher PG . A decline in the frequency of neonatal exchange transfusions and its effect on exchange-related morbidity and mortality. Pediatrics. 2007;120:27-32. doi:10.1542/peds.2006-2910