Failure to thrive in an infant has multiple etiologies and at times, is only manifestation of underlying serious disease. Bartter syndrome is a rare disease that manifests as failure to thrive. It can be diagnosed by a careful history, physical examination, and abnormal electrolyte pattern. It can be alleviated by appropriate management, whereas failure to recognize early can be life threatening. A case of severe failure to thrive in an infant due to neonatal form of Bartter syndrome, its manifestations, management, and outcome is presented in this article.
Bartter FC, Pronove P., Gill JRHyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. Am J Med. 1962;33:811-828.
2.
Proesmans W.Threading through the mizmaze of Bartter syndrome . Pediatr Nephrol. 2006;21:896-902.
3.
Gitelman HJ, Graham JB, Welt LGA new familial disorder characterized by hypokalemia and hypomagnesemia. Trans Assoc Am Physicians. 1966;79:221-235.
4.
Mackie FE, Hodson EM, Roy LP, Knight JFNeonatal Bartter syndrome-use of indomethacin in the newborn period and prevention of growth failure. Pediatr Nephrol. 1996;10:756-758.
5.
Jentsch TJ, Maritzen T., Zdebik AAChloride channel diseases resulting from impaired transepithelial transport or vesicular function. J Clin Invest. 2005 ;115:2039-2046.
6.
Simon DB, Karet FE, Hamdan JM, DiPietro A., Sanjad SA, Lifton RPBartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat Genet . 1996;13:183-188.
7.
Simon DB, Karet FE, Rodriguez-Soriano J., et al. Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK. Nat Genet. 1996; 14:152-156.
8.
Cortesi C., Fogila PE, Bettinelli A., Bianchetti MGPrevention of cardiac arrhythmias in pediatric patients with normotensive hypokalemic tubulopathy, current attitude among European pediatricians. Pediatr Nephrol. 2003;18:729-730.
9.
Pela I., Materassi M., Seracini D., Lavoratti G., Bettinelli A.Hypokalemic rhabdomyolysis in a child with Bartter syndrome. Pediatr Nephrol. 2005;20:1189-1191.
10.
D'Avanzo M. , Santinelli R., Tolone C., Bettinelli A., et al. Concealed administration of furosemide simulating Bartter syndrome in a 4.5 yr old boy. Pediatr Nephrol.1995;9:749-750.
11.
Yalcin E., Kiper N., Dogru D., Ozcelik U., Asian ATClinical features and treatment approaches in cystic fibrosis with pseudo-Bartter syndrome. Ann Trop Paediatr. 2005;25:119-124.
12.
Vaisbich MH , Fujimura MD, Koch VHBartter syndrome:benefits and side effects of long term treatment. Pediatr Nephrol. 2004 ;19:858-863.
