Synthetic Factor VIIa Concentrate to Treat Coagulopathy and Gastrointestinal Bleeding in an Infant with End-stage Liver Disease

Abstract

Get full access to this article

View all access options for this article.

References

1. Lam J , Tobias JD . Initial experience with octreotide in the pediatric population. Am J Therapeutics. 2002;8:409-415.

2. Van't Veer C , Mann KG . The regulation of the factor VII-dependent coagulation pathway: rationale for the effectiveness of recombinant factor Vl Ia in refractory bleeding disorders. Semin Thromb Hemostas. 2000;26:367-372.

3. Hedner U . Recombinant coagulation factor VIIa: from the concept to clinical application in hemophilia treatment in 2000. Semin Thromb Hemostas. 2000;26:363-366.

4. Lusher JM , Blatt PM , Penner JA , et al. Autoplex versus proplex: a controlled, double-blind study of effectiveness in acute hemarthroses in hemophiliacs with inhibitors to factor VIII. Blood. 1983;62:1135-1138.

5. Lusher JM . Thrombogenicity associated with factor IX complex concentrates. Semin Hematol. 1991;28:3-5.

6. Hedner U , Schulman S , Alberta KA , et al. Successful use of rFVIIa in a patient with severe hemophilia A subjected to synovectomy. Lancet. 1988;342(ii):1193-1193.

7. White B , McHale J , Ravi N , et al. Successful use of recombinant factor VIa (Novoseven) in the management of intractable post-surgical intra-abdominal hemorrhage. Br J Haematol. 1999;107:677-678.

8. Bernstein DE Jeffers L , Erhardtsen E , et al. Recombinant factor VIa corrects prothrombin time in cirrhotic patients: a preliminary study. Gastroenterology. 1997;113;1930-1937.

9. Jeffers L , Bernstein DE , Erhardtsen E , et al. The use of recombinant factor VIla in laparoscopy liver biopsy: a pilot trial (abstract). Gastroenterology. 1998;114:L0275-L0275.

10.

10. Erhardtsen R , Nony P , Dechavanne M , et al. The effect of recombinant factor VIIa (NovoSeven) in healthy volunteers receiving acenocoumarol to an International Normalized Ratio above 2.0. Blood Coagul Fibrin. 1998;9:741-748.

11.

11. Hendriks HGD , Meiher K , De Wolf JTM , et al. Reduced transfusion requirements by recombinant factor VIa in orthotopic liver transplantation. Transplantation. 2001;71:402-405.

12.

12. Kalicinski P , Kaminski A , Drewniak H , et al. Quick correction of hemostasis in two patients with fulminant liver failure undergoing liver transplantation by recombinant activated factor VII. Trans Proc. 1999;31:378-379.

13.

13. Chuansumrit A , Treepongkaruna S , Phuapradit P , et al. Combined fresh frozen plasma with recombinant factor VIa in restoring hemostasis for invasive procedures in children with liver disease. Thromb Haemost. 2001;85:748-749.

14.

14. Poon MC , Demers CJobin F , Wu JWY . Recombinant factor VIa is effective for bleeding and surgery in patients with Glanzmann thrombasthenia. Blood. 1999;94:3951-3953.

15.

15. Kristensen J , Killander A , Hippe E , et al. Clinical experience with recombinant factor VIla in patients with thrombocytopenia. Haemostasis. 1996;26(suppl 1):159-164.