We have previously proposed the osmofiltration method based on a modified Hanss hemorheometer to analyze distributions of erythrocytes in their ability to pass through membrane filters with 3
$\mu$
m pores. Upon decrease in medium osmolality (
$u$
) the erythrocyte volume increases. When cell volume becomes
$V=V_{\mathrm{cr}}$
at
$u=u_{\mathrm{cr}}$
, such cell loses its ability to pass through a 3
$\mu$
m pore. The flow rate of erythrocyte suspension containing cells with different
$u_{\mathrm{cr}}$
through a filter gradually decreases with decreasing medium osmolality. This rate becomes zero at some
$u=\Omega$
, when the number of non‐filterable cells in the applied sample approaches the number of pores in filter. Experimental determination of the dependencies of the filtration rate on medium osmolality for various hematocrit values allows to obtain
$\Omega$
for each hematocrit and, thereby, to assess the distribution of erythrocytes in
$u_{\mathrm{cr}}$
. Here, we propose a simplified version of this method, which allows screening of the erythrocytes in heterogeneous suspensions for the distribution in
$u_{\mathrm{cr}}$
by measuring
$\Omega$
for only two hematocrit values, 0.1% and 1%. Applications of the proposed method are exemplified by analysing the erythrocyte populations of healthy donors, of patients with microspherocytosis, hemochromatosis and normal erythrocyte populations in an acidic environment.
