CohenSPickEOppenheimJJ. eds. Biology of the Lymphokines. New York: Academic Press, 1979.
2.
MeagerA.Cytokines.Milton Keynes: Open University Press, 1990.
3.
MizelSB. The interleukins. FASEB J1989; 3: 2379–88.
4.
DamasPLerouxDNysMVrindtsYde GrootDFranchimontPCytokine serum levels during severe sepsis in human; IL-6 as a marker of severity. Ann Surg1992; 215: 356–62.
5.
RiikonenPSaarinenUMTeppoA-MMetsärinneKFyhrquistFJalankoH.Cytokine and acute phase reactant levels in serum of children with cancer admitted for fever and neutropenia. J Infect Dis1992; 166: 432–6.
6.
DuncombeASGottliebDJBianitiABrennerMK. Bioreactivity and immunoreactivity of tumour necrosis factor in cancer patients. Lancet1988; i: 248.
7.
SelbyPJHobbsSVinoCJacksonESmithIEMcElwainTH. Endogenous tumour necrosis factor in cancer patients. Lancet1988; i: 483.
8.
PetersenCMMollerBK. Immunological reactivity and bioactivity of tumour necrosis factor. Lancet1988; i: 934–5.
9.
BalkwillFOsborneRBurkeFNaylorSTalbotDDurbinHEvidence for tumour necrosis factor/cachectin production in cancer. Lancet1987; ii: 1229–32.
10.
MierJWVachinoCVan der MeerJWMNumerofRPAdamsSCannonJGInduction of circulating tumour necrosis factor (TNFα) on the mechanism of the febrile response to interleukin 2 (IL-2) in cancer patients. J Clin Immunol1988; 8: 426–36.
11.
EnglebertsIStephensSFrancotGJMvan der LindenCJBuurmanWA. Evidence for different effects of soluble TNF-receptors on various TNF measurements in human biological fluids. Lancet1991; ii: 515–16.
12.
AderbaDEngelmannHHornikVSkornickYLevoYWallachDIncreased serum levels of soluble receptors for tumour necrosis factor in cancer patients. Cancer Res1991; 51: 5602–7.
13.
HelfgottDCTatterSBSanthanamUClarickRHBhardwajNMayLTMultiple forms of IFN-β2-/IL-6 in serum and body fluids during acute bacterial infections. J Immunol1989; 142: 948–53.
14.
MayLTViguetHKenneyJSIdaNAllisonACSehgalPB. High levels of “complexed” interleukin-6 in human blood. J Biol Chem1992; 267: 19698–704.
15.
WollenbergGKLaMarrecJRosendalSGoniasSLHayesAM. Binding of tumour necrosis factor alpha to activated forms of human plasma alpha 2 macroglobulins. Am J Pathol1991; 138: 265–72.
16.
MatsudaTHiranoTNagasawaSKishimotoT.Identification of α2-macroglobulin as a carrier protein for IL-6. J Immunol1989; 142: 148–52.
17.
HiranoTTagaTYamanalsiTMatsudaTYasukawaKHirataYMolecular cloning of the cDNAs for Interleukin-6/B-cell stimulatory factor 2 and its receptor. Ann NY Acad Sci1989; 557: 167–80.
18.
MayLTSanthanamUTatterSBGhrayebJSehgalPB. Multiple forms of human Interleukin-6. Ann NY Acad Sci1989; 557: 114–21.
19.
MayLTGhrayebJSanthanamUTatterSBSthoegerZHelfgottDCSynthesis and secretion of multiple forms of β2-interferon/B-cell differentiation factor 2/hepatocyte stimulating factor by human fibroblasts and monocytes. J Biol Chem1988; 263: 7760–6.
20.
WeberTHKiapyahoKlTannerP.Endogenous interference in immunoassays in clinical chemistry. A review. Scand J Clin Lab Invest1990; 50 (suppl 201): 77–82.
21.
HamiltonRGWhittingtonKWarnerNBArnettFC. Human IgM rheumatoid factor reactivity with rabbit, sheep, goat and mouse immunoglobulin. Clin Chem1988; 4: 1165.
22.
ThompsonRJJacksonAPLangboisN.Circulating antibodies to mouse monoclonal immunoglobulins in normal subjects—incidence, species specificity and effects on a two-site assay for creatine kinase—MB isoenzyme. Clin Chem1986; 32: 476–81.
BoneRC. The pathogenesis of sepsis. Ann Int Med1991; 115: 457–69.
25.
WaageAHalstensenAEspevikT.Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet1987; i: 355–7.
26.
GirardinEGrauGEDayerJ-MRoux-LombardPLambertPH. Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. New Eng J Med1988; 319: 397–400.
27.
De GrooteMAMartinMADensenPPfallerMAWenzelRP. Plasma tumor necrosis factor levels in patients with presumed sepsis. JAMA1989; 262: 249–51.
28.
DebetsJMHKampmeijerRvan der LindenMPMHBuurmanWAvan der LindenCJ. Plasma tumor necrosis factor and mortality in critically ill septic patients. Crit Care Med1989; 17: 489–94.
29.
DamasPReuterAGysenPDemontyJLamyMFranchimontP.Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans. Crit Care Med1989; 17: 975–8.
30.
MarksJDMarksCBLuceJMMontgomeryABTurnerJMetzCAMurrayJF. Plasma tumor necrosis factor in patients with septic shock. Am Rev Respir Dis1990; 41: 94–7.
31.
OffnerFPhilippéJVogelaersDColardynFBaeleGBaudrihayeMSerum tumor necrosis factor levels in patients with infectious disease and septic shock. J Lab Clin Med1990; 116: 100–5.
32.
CannonJGTompkinsRGGelfandJAMichieHRStanfordGGVan Der MeerHWMCirculating interleukin-1 and tumor necrosis factor in septic and experimental endotoxin fever. J Infect Dis1990; 161: 79–84.
33.
CalandraTBaumgartnerJ-DGrauGEWuMMLambertP-HSchellekensJPrognostic values of tumor necrosis factor/cachectin, interleukin-1, interferon-α and interferon-γ in the serum of patients with septic shock. J Infect Dis1990; 161: 982–7.
34.
HyersTMTricomiSMDettenmeierPAFowlerAA. Tumor necrosis factor levels in serum and bronchoalveolar lavage fluid of patients with the adult respiratory distress syndrome. Am Rev Respir Dis1991; 144: 268–71.
35.
DofferhoffASMBomVJJde Vries-HospersHGvan IngenJvd MeerJHazenbergBPCPatterns of cytokines, plasma endotoxin, plasminogen activator inhibitor, and acute-phase proteins during the treatment of severe sepsis in humans. Crit Care Med1992; 20: 185–92.
36.
SullivanJSKilpatrickLCostarinoATLeeSCHarrisMC. Correlation of plasma cytokine elevations with mortality rate in children with sepsis. J Pediatr1992; 120: 510–15.
37.
Members of the American College of Chest Physicians/Society of Critical Care Medicine Concensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Concensus Conference Committee: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med1992; 20: 864–74.
38.
SeckingerPIsaazSDayerJ-M.Purification and biological characterisation of a specific TNFα inhibitor. J Biol Chem1989; 264: 11966–73.
39.
EngelmannHAderkaDRubinsteinMRotmanDWallachD.A tumor necrosis factor-binding protein purified to homogenicity from human urine protects cells from tumor necrosis factor. J Biol Chem1989; 264: 11974–80.
40.
SeckingerPVeyETurcattiGWingfieldPDayerJ-M.Tumor necrosis factor inhibitor: Purification, NH2-terminal amino acid sequence and evidence for anti-inflammatory and immunomodulatory activities. Eur J Immunol1990; 20: 1167–74.
Van ZeeKJKohonoTFisherERockCSMoldawerLLLowrySF. Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor α in vitro and in vivo. Proc Natl Acad Sci USA1992; 89: 4845–9.
43.
FoleyNLambertCMcNicolMJohnsonNRookGAW. An inhibitor of the toxicity of tumour necrosis factor in the serum of patients with sarcoidosis, tuberculosis and Crohn's disease. Clin Exp Immunol1990; 80: 395–9.
44.
KalinkovichAEnglemannHHarpazNBursteinRBarakVKalickmanIElevated serum levels of soluble tumour necrosis factor receptors (sTNF-R) in patients with HIV infection. Clin Exp Immunol1992; 89: 351–5.
45.
SpinasGAKellerUBrockhausM.Release of soluble receptors for tumor necrosis factor (TNF) in relation to circulating TNF during experimental endotoxinemia. J Clin Invest1992; 90: 533–6.
46.
GirardinERoux-LombardPGrauGESuterPGallatiHDayerJM. Imbalance between tumour necrosis factor-alpha and soluble TNF receptor concentrations in severe meningococcaemia. Immunology1992; 76: 20–3.
47.
SymonsJAEastgateJADuffGW. Purification and characterization of a novel soluble receptor for interleukin-1. J Exp Med1991; 174: 1251–4.
48.
FanslowWCSimsJESassenfeldHMorrisseyPJGillesSDowerSKRegulation of alloreactivity in vivo by a soluble form of the interleukin-1 receptor. Science1990; 248: 739–42.
49.
GranowitzEVSantosAAPoutisiakaDDCannonJGWilmoreDWWolffSMProduction of interleukin-1-receptor antagonist during experimental endotoxaemia. Lancet1991; ii: 1423–4.
50.
WakabayashiGGelfandJAJungWKConnollyRJBurkeJFDinnarelloCA. Staphylococcus epidemidis induces complement activation, tumor necrosis and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. J Clin Invest1991; 87: 1925–35.
51.
CannonJGVan der MeerJWMKwiatkowskiDEndresSLonnemannGBurkeJFInterleukin-1β in human plasma: Optimization of blood collection, plasma extraction, and radioimmunoassays methods. Lymphokine Res1988; 7: 457–67.
52.
HopkinsSJHoltIHumphriesM.Removal of inhibitory activity and determination of biologically active IL-1 in biological fluids. J Immunol Meth1990; 133: 127–31.
53.
HerzykDJBergerAEAllenJNWewersMD. Sandwich ELISA formats designed to detect 17 kDa IL-1β significantly underestimate 35 kDa IL-1β. J Immunol Meth1992; 148: 243–54.
54.
DinarelloCA. ELISA kits based on monoclonal antibodies do not measure total IL-1β synthesis. J Immunol Meth1992; 148: 255–9.
55.
DinarelloCA. The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome. J Infect Dis1991; 163: 1177–84.
56.
WaageABrandtzaegPHalstensenAKierulfPEspevikT.The complex pattern of cytokines in serum from patients with meningococcal septic shock. J Exp Med1989; 169: 333–8.
57.
HackCEDe GrootERFelt-BersmaRJFNuijensJHVan SchijndelRJM StrackIncreased plasma levels of interleukin-6 in sepsis. Blood1989; 74: 1704–10.
58.
CalandraTGerainJHeumannDBaumgarnerJ-DGlauserM.Swiss-Dutch J5 Immunoglobulin Study Group. High circulating levels of interleukin-6 in patients with septic shock: Evolution during sepsis, prognostic value, and interplay with other cytokines. Am J Med1991; 91: 23–9.
59.
NovickDEnglemannHWallachD.Purification of soluble cytokine receptors from normal urine by ligand-affinity and immunoaffinity chromatography. J Chromatogr1990; 510: 331–7.
60.
TagaTHibiMHirataYYamasakiKYasukawaKMatsudaTInterleukin-6 triggers the association of its receptor with a possible signal transducer, gp 130. Cell1989; 58: 573–81.
61.
HeneyDNovickDLewisIJBaileyCCWhicherJ.Interleukin-6 (IL-6) and Soluble IL-6 Receptor; A study of their relationship with fever and neutrophil recovery in febrile neutropenia. Med Ped Onc1992; 20: 376.
62.
NathanCSpornM.Cytokines in context. J Cell Biol1991; 113: 981–6.