Salivary theophylline concentrations in neonates were measured by a homogeneous enzyme immunoassay and compared with serum concentrations. Free serum theophylline concentrations were also compared with salivary concentrations and the values obtained were almost identical. Results using the immunoassay agreed well with those obtained using a high-performance liquid chromatographic procedure (HPLC).
ArandaJVSitarDSParsonsWDLoughnanPNNeimsAH. Pharmacokinetic aspects of theophylline in premature newborns. N Engl J Med1976; 295: 413–16.
2.
DawsonAHWhyteIM. The assessment and treatment of theophylline poisoning. Med J Aust1989; 151: 689–93.
3.
BreinerRMcCombRLewisS. Positive interference with immunoassay of theophylline in serum of uremics. Clin Chem1985; 31: 1575–6.
4.
RoweDJFWatsonIDWilliamsJBerryDJ. The clinical use and measurement of theophylline. Ann Clin Biochem1988; 25: 4–26.
5.
KnottCBatemanMReynoldsF. Do saliva concentrations predict plasma unbound theophylline concentrations? A problem re-examined. Br J Clin Pharmacol1984; 17: 9–14.
6.
KhannaNNBadaHSSomaniSM. Use of salivary concentrations in the prediction of serum caffeine and theophylline concentrations in premature infants. J Pediatr1980; 96: 494–9.
7.
TobackJWGalPErkanNVRoopCRobinsonH. Usefulness of theophylline saliva levels in neonates. Ther Drug Monit1983; 5: 185–9.
8.
WallaceS. Altered plasma albumin in the newborn infant. Br J Clin Pharmacol1977; 4: 82–5.
9.
MorselliPLFranco-MorselliRBassiL. Clinical pharmacokinetics in newborns and infants. Clin Pharmacokinet1980; 5: 485–527.
10.
BlanchardJHarveySMorganWJ. Serum/Saliva correlations for theophylline in asthmatics. J Clin Pharmacol1991; 31: 565–70.
11.
UdenDLMillerKWStrandLMJohnsonPBDarwinEZ. Saliva-serum theophylline concentrations: Substantial intrapatient and interpatient variation in predicting serum concentrations. Ther Drug Monit1981; 3: 143–50.
12.
GaoYPonsGReyERichardMOd'AthisPBertinLCould saliva stand for plasma in theophylline monitoring in asthmatic children? Still a controversial problem. Fundam Clin Pharmacol1992; 6: 191–6.
13.
DrobitchRKSvenssonCK. Therapeutic drug monitoring in saliva. Clin Pharmacokinet1992; 23: 365–79.