We have studied the relationship between serum glucose and urate in 260 699 men and 214 118 women from Sweden, and 140 084 men and 30 653 women from the UK. We found an increase in mean serum urate with increasing glucose concentrations up to 7·0 mmol/L in men and 9·0 mmol/L in women. Thereafter increasing glucose values were accompanied by a statistically significant decrease in urate concentrations. This fall was particularly marked in younger subjects. We believe this may have important implications for the free radical status of diabetics.
WeissTESegaloffAMooreC.Gout and diabetes. Metab Clin Exp1957; 6: 103–6.
2.
BeckettAGLewisJG. Gout and serum uric acid in diabetes mellitus. Q J Med1960; 29: 443–58.
3.
YanoKRhoadsGGKaganA.Epidemiology of serum uric acid among 8000 Japanese American men in Hawaii. J Chron Dis1977; 30: 171–84.
4.
HermanJBGoldbourtV.Uric acid and diabetes; observations in a population study. Lancet1982; ii: 240–3.
5.
CookDGShaperAGThelleDSWhiteheadTP. Serum uric acid, serum glucose and diabetes: Relationships in a population study. Postgrad Med J1986; 62: 1001–6.
6.
BonerGRieselbackRE. The effect of glucose upon reabsorptive transport of urate by the kidney. Adv Expl Med Biol1974; 41: 781–7.
7.
FossatiPPrencipeLBertiG.Use of 3·5—dichloro-2-hydroxybenzene sulphonic acid/4—animophenazone chromogenic system in direct enzyme assay of uric acid in serum and urine. Clin Chem1980; 26 (2): 227–31.
