Serum osteocalcin did not show any response to the onset of osteosarcoma in Paget's disease of bone whereas serum alkaline phosphatase increased rapidly. This suggests that osteocalcin is not useful in the diagnosis and management of Paget's osteosarcoma and does not reflect the same osteoblastic processes in bone as serum alkaline phosphatase.
WorsfoldMSharpCADavieMWJ. Serum osteocalcin and other indices of bone formation: An 8-decade population study in healthy men and women. Clin Chim Acta1988; 178225–36.
2.
BergmanILoxleyR. Two improved and simplified methods for the spectrophotometric determination of hydroxyproline. Anal Chem1963; 35: 1961–5.
3.
SlovikDMGundbergCMNeerRMLianJB. Clinical evaluation of bone turnover by serum osteocalcin measurements in a hospital setting. J Clin Endocrinol Metab1984; 59: 228–30.
4.
CoultonLAPrestonCJCouchMKanisJA. An evaluation of serum osteocalcin in Paget's disease of bone and its response to diphosphonate treatment. Arthritis Rheum1988; 31: 1142–7.
5.
DavieMWJWorsfoldMSharpCA. Assessment of response to APD in Paget's Disease of bone. Bone1989; 10: 475.