The levels of glycated haemoglobin, fetal haemoglobin and methaemoglobin in 618 Saudi subjects were determined. A statistically significant decrease in the percentage of glycated haemoglobin was observed in all haemoglobinopathic groups studied in comparison to normal controls. However, there was no significant difference in the percentage of glycated haemoglobin in patients with sickle cell anaemia when compared with those sickle cell subjects who were also glucose-6-phosphate dehydrogenase deficient. This suggests that there is little survival advantage or disadvantage in the combination of glucose-6-phosphate dehydrogenase deficiency and sickle cell anaemia.
References
1.
GelpiAP. Glucose-6-phosphate dehydrogenase deficiency in Saudi Arabia: A survey. Blood1965; 25: 486–93.
2.
El HazmiMHF. Hemoglobin disorders: A pattern for thalassaemia and hemoglobinopathies in Arabia. Acta Haemat1982; 68: 43–51.
3.
PiomelliSReindorfCAArzanianMTCorashLM. Clinical and biochemical interactions of glucose-6-phosphate dehydrogenase deficiency and sickle cell anemia. New Engl J Med1972; 287: 213–17.
4.
BeutlerEJohnsonCPowarsDWestC.Prevalence of glucose-6-phosphate dehydrogenase deficiency in sickle-cell disease. N Engl J Med1974; 290: 826–8.
5.
SteinbergMHDreilingBJ. Glucose-6-phosphate dehydrogenase deficiency in sickle cell anemia. Ann Intern Med1974; 80: 217–21.
WarsyAS. Frequency of glucose-6-phosphate dehydrogenase deficiency in sickle cell disease. Hum Hered1985; 35: 143–7.
8.
PenzerSKronikGLechnerKBattelheimPNeumannEDudicakR.Glycosylated haemoglobins (GHb): An index of red cell survival. Blood1982; 59: 1348–50.
9.
AlayashAIDafallahAWilsonMT. Glycosylated hemoglobin in Saudi sickle cell patients with glucose-6-phosphate dehydrogenase deficiency. Acta Haemat1987; 78: 54–6.
10.
DrabkinDL. Spectrophotometric studies IXV. The crystallographic and optical properties of the haemoglobin of man in comparison with those of other species. J Biol Chem1946; 164: 703–23.
11.
RodkeyFLHillTAPittsLLRobertsonRF. Spectrophotometric measurement of carboxyhaemoglobin and methaemoglobin in blood. Clin Chem1979; 25: 1388–93.
12.
BetkeKMartiHRSchlictI.Estimation of small percentages of foetal hemoglobin. Nature, Lond1959; 184: 1877–9.
13.
McDonaldMHShapiroRBieichmanMSolwayJNimmHF. Glycosylated minor components of human adult haemoglobin, purification, identification and partial structural analysis. J Biol Chem1978; 253: 2327–31.
14.
BattistuzziGEsanGJFFasuanFAMedianoGLuzzattoL.Comparison of GdA and GdB activities in Nigerians. A study of the variation of the G-6-PD activity. Am J Hum Genet1977; 29: 31–6.
15.
HuismanTMJSchroderWABrodieANMaysonSMJakwayJ. Microchromatography of hemoglobins. III. A simplified procedure for the determination of hemoglobin A2. J Lab Clin Med1975; 86: 700–2.
16.
SpjotrollEStolineMR. An extension of the T-method of multiple comparison to include the cases with unequal sample sizes. J Am Stat Assoc1973; 68: 975–8.
17.
ElseweidyMMAbrahamAC. The relationship between fetal hemoglobin levels and glycosylation in sickle cell diseases. Am J Haematol1984; 16: 375–81.
18.
BerniniLLatteBSiniscalcoMSurvival of 51Cr-labelled red cells in subjects with thalassemia trait or G6PD deficiency or both abnormalities. Br J Haemat1984; 10: 171–80.
19.
FitzgibbonsJFKolerRDJonesRT. Red cell agerelated changes of hemoglobins A1a+b and A1c in normal and diabetic subjects. J Clin Invest1976; 58: 820–4.
20.
HellerPBestWRNelsonRBBecktelJ.Clinical implication of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency in hospitalized Black male patients. N Engl J Med1979; 300: 1001–5.
21.
NoguchiCTSchechterAN. Sickle hemoglobin polymerization in solutions and gels. Am Rev Biophys Chem1985; 14: 239–63.
