A method for the radioiodination of antibodies for therapy is described. The method resulted in a high efficiency of labelling (88–94%) with negligible damage to the antibody. Good localisation of labelled antibody was demonstrated. Doses of radiation to operators were very low.
References
1.
MatherSJWardBG. High efficiency iodination of monoclonal antibodies for radiotherapy. J Nucl Med1987; 28: 1034–6.
2.
ReayP.Use of N-bromosuccinimide for the iodination of proteins for radioimmunoassay. Ann Clin Biochem1982; 19: 129–33.