Fructosamine was measured in the serum of 62 patients with insulin-dependent diabetes (IDD) and 32 non-diabetics and the results compared with glycated albumin levels (GSA) measured using the affinity medium Cibarcron blue F3GA.
Good correlations were found both for the IDD patients (r=0·93) and the combined group of IDD plus non-diabetics (r=0·95). We conclude, that fructosamine measurements accurately reflect GSA concentrations, and, therefore, provide a practical method for assessing intermediate term glycaemia in IDD.
References
1.
KennedyALMerimeeTJ. Glycosylated serum protein and hemoglobin A1 levels to measure control of glycemia. Ann Internal Med1981; 95: 56–8.
2.
LloydDRNottMMarplesJ. Comparision of serum fructosamine with glycosylated serum protein (determined by affinity chromatography) for the assessment of diabetic control. Diabetic Medicine1985; 2: 474–8.
3.
PasiKJToopMJJohnG.Serum fructosamine: correlation with glycated albumin (poster). Annual Meeting, Association of Clinical Biochemists, Cardiff, 1985.
4.
MoscaACareniniAZoppiFPlasma protein glycation as measured by fructosamine assay. Clin Chem1987; 33: 1141–6.
5.
WinocourPHBhatnagarDReedPDoes the measurement of serum fructosamine accurately reflect levels of glycated albumin in insulin-dependent diabetes. Ann Clin Biochem1987; 24: 47–52.
6.
FinkCGGlycosylated haemoglobin (letter). News Sheet of the Assoc of Clin Biochem1985; 263: 20–2.
7.
WalkerSWHowieAFSmithAF. The measurement of glycosylated albumin by reduction of alkaline nitro-blue tetrazolium. Clin Chim Acta1986; 156: 197–206.
8.
LemonMForrestAR. Fructosamine activity of proteins in serum. Clin Chem1986; 32: 2101.
