Plasma creatine kinase (CK) activity and lean body mass (LBM) (by anthropometry) were measured in 120 women (20–82 years) and 70 men (20–82 years). Plasma CK activity and LBM was higher in men than in women. In men plasma CK activity was significantly correlated (product moment correlation coefficient) with LBM and negatively with age. In women plasma CK activity was significantly correlated with age. Partial correlation coefficient calculation showed a significant correlation between plasma CK and LBM both in men and in women. We conclude that in healthy subjects the plasma CK activity is related to LBM, but the LBM is not a major determinant of plasma activity in healthy subjects.
References
1.
AebiURichterichRColomboJPRossiE. Progressive muscular dystrophy, Part 2 (biochemical identification of the sex-linked juvenile (Duchenne) type by serum creatine phosphokinase determinations). Enzyme Biol Clin1961; 1: 61–74.
2.
LaneRJMRosesAD. Variation of serum creatine kinase levels with age in normal females—Implications for genetic counselling in Duchenne muscular dystrophy. Clin Chim Acta1981; 113: 75–86.
3.
SmithIDEltonRAThompsonWHS. Carrier detection in x-linked recessive (Duchenne) muscular dystrophy—Serum creatine phosphokinase values in premenarcheal, menstruating, post menopausal and pregnant normal women. Clin Chim Acta1979; 98: 207–16.
4.
MeltzerMY. Factors affecting serum creatine phosphokinase levels in the general population. The role of race, activity and age. Clin Chim Acta1971; 33: 165–72.
5.
HughesBP. A method for estimation of serum creatine kinase and its use in comparing creatine kinase and aldolase in normal and pathological sera. Clin Chim Acta1962; 7: 597–603.
6.
GarciaW. Elevated creatine phosphokinase levels associated with large muscle mass. Another pitfall in evaluating clinical significance of total serum CPK activity. J Am Med Assoc1974; 228: 1395–6.
7.
NovakLPTilleryGW. Relationship of serum creatine phosphokinase to body composition. Human Biology1977; 49: 375–80.
8.
NortonJPClarksonPMGravesJESerum creatine kinase activity and body composition in males and females. Human Biology1985; 57: 591–8.
9.
DurninJVGAWormsleyJ. Body fat assessed from total body density and its estimation from skinfold thickness: measurement of 481 men and women aged from 16 to 72 years. J Nutr1974; 32: 77–97.
10.
SteelRGDTorrieH.Principles and Procedures of Statistics: Special Reference to the Biological Science.London: McGraw Hill Co, 1960.
11.
BlackHRQuallichHGareleckCB. Racial differences in serum creatine kinase levels. Am J Med1986; 81: 479–87.
12.
MairiauxPBuchetJBettonvilleMN. Serum creatine kinase: relationship to lean body mass in a ‘real-life’ situation. Clin Chem1984; 30: 1428–9.
13.
LottJATholenDWMassionCG. Determination of reference ranges for serum enzymes via a large interlaboratory survey. Arch Pathol Lab Med1987; 111: 9–15.
14.
SwaminathanRHoCSLauChu MingDonnanS. Relation between plasma creatinine and body size. Clin Chem1986; 32 (2): 371–3.
