A group of oligomenorrhoeic women without obesity or hirsuties was investigated with high-resolution ultrasound, laparoscopy and biochemical parameters. In this series, polycystic ovaries (PCO), as defined by ultrasound and laparoscopy, are a common cause of oligomenorrhoea in women without the classic symptoms, and were strongly associated with an elevated free androgen index (FAI). Despite an elevated FAI, these women were not hirsute, It would seem reasonable to include a FAI in the investigation of the oligomenorrhoeic woman, along with the more ‘standard’ tests, such as thyroid function and a prolactin level.
References
1.
AdamsJPoisonDWFranksS. Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br Med J1986; 293: 355–9.
2.
SteinIFLeventhalML. Amenorrhoea associated with bilateral polycystic ovaries. Am J Obstet Gynecol1953; 29: 181–91.
3.
GoldzieherJWGreenJA. The polycystic ovary: Clinical and histological features. J Clin Endocrinol Metab1962; 22: 325–38.
4.
MathurRSMoodyLOLandgrebeSPlasma androgens and sex-hormone binding globulin in the evaluation of hirsute females. Fertil Steril1981; 35: 29–35.
5.
CunninghamSKLoughlinTCullitonMThe relationship between sex steroids and sex hormone binding globulin in plasma in physiological and pathological conditions. Ann Clin Biochem1985; 22: 489–96.
6.
CarterGDHollandSMAlaghband-ZadehJInvestigation of hirsutism: testosterone is not enough. Ann Clin Biochem1983; 20: 262–3.
7.
CollinsWPMansfieldMDAlladinaNSRadioimmunoassay of plasma testosterone. J Steroid Biochem1972; 3: 333–48.
8.
IqbalMJJohnsonMW. Study of steroid protein binding by a novel ‘two tier’ column employing cibracon blue F3-A-sepharose 4B 1-sex-hormone binding globulin. J Steroid Biochem1977; 8: 977–83.
