We have made an evaluation of glycosylated haemoglobin measurements by affinity chromatography in a paediatric population. Age-related reference values for non-diabetic infants and children are reported. A poor correlation (r=0·24) was found between glycosylated haemoglobin values in 26 insulin-dependent diabetic children and the paediatrician's independent assessment of clinical control.
References
1.
WilliamsMLSavageDCL. Glycosylated haemoglobin levels in children with diabetes mellitus. Arch Dis Child1979; 54: 295–8.
2.
MannNPJohnstonDI. Total glycosylated haemoglobin (HbA1) levels in diabetic children. Arch Dis Child1982; 57: 434–7.
3.
KaplanLAClineDGartsidePHemoglobin A1 in hemolysates from healthy and insulin-dependent diabetic children, as determined with a temperature-controlled mini-column assay. Clin Chem.1982; 28: 13–18.
4.
YatscoffRWTevaarwerkGJMClarsonCLInterference of fetal hemoglobin and labile glycosylated hemoglobin with measurements of glycosylated hemoglobin. Clin Chem.1983; 29: 543–5.
5.
ScottMGHoffmanJWMeltzerVNEffects of azotemia on results of the Boronate-agarose affinity and ion-exchange methods for glycated hemoglobin. Clin Chem.1984; 30: 896–8.
6.
BrooksAPMetcalfeJDayJLIron deficiency and glycosylated haemoglobin A1. Lancet.1980; ii: 141.
7.
FalkoJMO'DorisioTMCatalandS. Spurious elevations in glycosylated hemoglobin (HbA1) secondary to hypertriglyceridemia. Arch Intern Med.1982; 142: 1370–1.
8.
AlcyassincH. Low proportions of glycosylated hemoglobin associated with hemoglobin S and hemoglobin C. Clin Chem.1979; 25: 1484–86.
9.
GarlickRLMazerJSHigginsPJCharacterization of glycosylated haemoglobins. J Clin Invest1983; 71: 1062–72.
10.
Van HeyningenCDaltonRG. Glycosylated haemoglobin in iron deficiency anaemia. Lancet.1985; i, 874.
11.
FairbanksVFZimmermanBR. Measurement of glycosylated hemoglobin by affinity chromatography. Mayo Clin Proc1983; 58: 770–3.
12.
KlenkDCHermansonGTKrohnRIDetermination of glycosylated hemoglobin by affinity chromatography. Clin Chem.1982; 28: 2088–94.
13.
JacksonRL. Growth and maturation in children with insulin-dependent diabetes mellitus. Pediatric Clinic of N America1984; 31: 545–67.
14.
HallPMCookJGHGouldBJ. An inexpensive, rapid and precise affinity chromatography method for the measurement of glycosylated haemoglobins. Ann Clin BioChem.1983; 20: 129–35.
15.
BrattebyLGarbyLGrothTStudies on erythro-kinetics in infancy. Acta Paediat Scand.1968; 57: 311–20.
16.
CornblathMReisnerSH. Blood glucose in the neonate and its clinical significance. N Engl J Med.1965; 273: 378–81.
17.
AbrahamECPerryREStallingsM. Application of affinity chromatography for separation and quantitation of glycosylated haemoglobins. J Lab Clin Med.1983; 102: 187–97.
18.
GonenBRubensteinAHRochmanHHaemoglobin A1: an indicator of the metabolic control of diabetic patients. Lancet.1977; ii: 734–7.
19.
LanoeRSonaJThibultNGlycosylated haemoglobin concentrations and Clinitest results in insulin-dependent diabetes. Lancet.1977; ii: 1156–7.
20.
SticklandMHPatonRCWalesJK. Haemoglobin A1c concentrations in men and women with diabetes. Br Med J1984; 289: 733.