An Investigation into the Source of the Deglutamated Metabolites of Methotrexate in Patients Treated with High Dose Infusions

Johns DG Loo TL . Metabolite of 4-amino 4-deoxy-N10-methyl glutamic acid (MTX). J Pharmaceut Sci. 1967; 56: 356–9.

Breihaupt H Kuenzelen E Goebel G . Rapid high-pressure liquid chromatographic determination of methotrexate and its metabolites 7-hydroxymethotrexate and 2,4-diamino-N10-methylpteroic acid in biological fluids. Anal BioChem. 1982; 121: 103–13.

Valerino DM Johns DG Zaharko DS Oliverio VT . Studies of the metabolism of methotrexate by intestinal flora. Biochem Pharmacol 1972; 21: 821–31.

Donehower RC Hande KR Drake JC Chabner BA . Presence of 2,4-diamino-N10 methylpteroic acid after high dose methotrexate. Clin Pharmacol Therap 1979; 26: 63–72.

Chatterji DC Frazier AC Golbreli JF . Identification and quantitation of impurities in methotrexate. J Pharmaceut Sci. 1978; 67: 622–4.

Stewart CF Crom WR Lee GC . Pharmacokinetics and monitoring techniques for antineoplastic agents. In: Mungall D , ed. Applied Clinical Pharmacokinetics. New York: Raven press, 1983; 329–37.

Hendel J . Intracellular metabolites of methotrexate. Chemiotheripia Oncologica 1978; 2: 146–7.

Farid YYZ Watson ID Harding NGL Stewart MJ . HPLC as a means of following an in vitro synthesis of 7-hydroxymethotrexate. In: Reid E Leppard JP eds. Drug Metabolite Isolation and Determination. New York: Plenum Press, 1983(a); 141–2.

Farid YYZ Watson ID Stewart MJ . An assay for methotrexate and its metabolites in serum and urine by ion-pair high-performance liquid chromatography. J Pharmaceut Biomed Anal 1983; 1: 55–63.

Johns DG Jannatti AT Santorelli AC Boothi BA Bertino JR . Enzyme oxidation of methotrexate and aminopterin. Life Sci. 1964; 3: 1383–8.