Discriminant function analysis has been applied to the results of activity and inhibitor measurements carried out on a series of 229 specimens using benzoylcholine and butyrylthiocholine as substrate. The discriminant function was more effective in differentiating cholinesterase genotypes than either a single test or a combination of two tests.
References
1.
WhittakerMBrittenJJ. A comparison of some methods of phenotyping the plasma cholinesterase variants using benzoylcholine as substrate. Ann Clin Biochem1981; 18: 9–14.
2.
FisherRA. The use of multiple measurements in taxonomic problems. Ann Eugen1936; 7: 179–88.
WildingPBradwellARHolderRLApplications of discriminant analysis in clinical chemistry. Adv Automated Anal1976; 1: 51–4.
5.
KalowWLindsayHA. A comparison of optical and manometric methods for the assay of human serum cholinesterase. Can J Biochem Physiol1955; 33: 568–74.
6.
DasPKLiddellJ.Value of butyrylthiocholine assay for identification of cholinesterase variants. J Med Genet1970; 7: 351–5.
7.
McQueenMRLepinskieFStricklandRDAbnormal enzyme phenotype (Ea1Ef1): normal response to succinylcholine. Can Anaesth Soc J1979; 26: 99–103.
8.
LiddellJLehmannHDaviesD.Harris and Whittaker's pseudocholinesterase variant with increased resistance to fluoride. A study of 4 families and identification of the homozygote. Acta Genet Statist Med1963; 13: 95–108.
9.
DixonWJBrownMB. (eds). Biomedical Computer Programmes P-series, 1979. Berkeley, California: University of California Press, 1979; 711–73.