The Abbott TDX system utilises the principles of fluorescence polarisation and competitive binding analysis for the quantitation of drug levels in plasma. The system proved easy to use, and produced reliable results rapidly. The high cost of reagents is balanced by the fact that the reagents are stable and therefore the assays can be calibrated infrequently.
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VasiliadesJHalsteadTKiteleyT, Serum determination of theophylline, phenytoin, pheno-barbital, gentamicin and tobramycin by fluorescence polarization immunoassay and enzyme immunoassay. Clin Chem.1983; 29: 1156.
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WalsonPDWarrenDCoxS. Comparison of methods for clinical determination of serum theophylline in children. Clin Chem.1983; 29: 1157.
