Bisalbuminaemia occurring together with paraproteinaemia in a case of proven myelomatosis is described. The albumin variant was investigated by dye-binding, electrophoresis at pH 5·0, 6·8, and 8·6, and by relative mobility studies compared with known genetically inherited variants. The present variant was indistinguishable from the previously described Pollibauer type.
References
1.
FineJMMarneuxMLambinP.Human albumin variants: NomenClature of allotypes observed in Europe and quantitative estimation of the relative mobilities. Rev Franc Transf Immuno-Hematol1982; 25: 149–63.
2.
PortaFBosoniMAPozzoliETransient bisalbumins induced by pancreatic disease and by penicillin therapy. Geographic distribution of hereditary variants in Italy. Lab J Res Lab Med.1980; 8: 129–40.
WeitkampLRSalzanoFMNeelJVHuman serum albumin, twenty three genetic variants and their population distribution. Ann Hum Genet1973; 36: 381–5.
5.
FineJMMarneuxMNorthML.Human serum albumin variants: Determination and repartition of allotype in 24 cases of bisalbuminaemia in the French population. Rev Europ Etude Clin Biol1976; 25: 291–4.
6.
GavrilescuKKohnJ.Immunoglobulin anomaly occurring together with bisalbuminaemia. Protides of Biol Fluids1966; 14: 373–8.
7.
WiemeRJ.On the occurrence of different types in genetically determined bisalbuminaemia. Protides of Biol Fluids1962; 9: 221–4.