The Broughton equation for carryover constant k contains an assumption. It is shown that a slightly different equation can be derived in which there are no assumptions. A procedure is described whereby knowledge of the carryover constant k can be used to correct analytical results in computer-controlled instruments. In a commercial instrument, use of the wrong correction algorithm can lead to errors of 10% in the carryover correction.
References
1.
BroughtonPMG. A guide to automation in clinical chemistry. ACB Technical Bullein No. 16 1969. Recommended scheme for the evaluation of instruments for automatic analysis in the clinical biochemistry laboratory. J Clin Path1969; 22: 278–85.
2.
HirstADHoworthPJN. Estimation of carryover in continuous flow systems. Ann Clin Biochem1975; 12: 32.
